Sdr42e1 MGI Mouse Gene Detail - MGI:1921282 - short chain dehydrogenase/reductase family 42E, member 1

Symbol

Sdr42e1
Name

short chain dehydrogenase/reductase family 42E, member 1
Synonyms

4632417N05Rik

Feature Type

protein coding gene
IDs

MGI:1921282
NCBI Gene: 74032
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:118388138-118400428 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 64.69 cM
Mapping Data

2 experiments

SNPs within 2kb

425 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921282	protein coding gene	Chr8:118388138-118400428 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034175	protein coding gene	Chr8:120868035-120880312 (-)
A/J	MGP_AJ_G0034155	protein coding gene	Chr8:115916497-115928936 (-)
AKR/J	MGP_AKRJ_G0034082	protein coding gene	Chr8:119285758-119298971 (-)
BALB/cJ	MGP_BALBcJ_G0034149	protein coding gene	Chr8:116116038-116128323 (-)
C3H/HeJ	MGP_C3HHeJ_G0033860	protein coding gene	Chr8:120015370-120030105 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034669	protein coding gene	Chr8:124931648-124943920 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031611	protein coding gene	Chr8:108834717-108848066 (-)
CAST/EiJ	MGP_CASTEiJ_G0033187	protein coding gene	Chr8:119900253-119912617 (-)
CBA/J	MGP_CBAJ_G0033833	protein coding gene	Chr8:129475496-129487755 (-)
DBA/2J	MGP_DBA2J_G0033989	protein coding gene	Chr8:115144414-115156693 (-)
FVB/NJ	MGP_FVBNJ_G0033932	protein coding gene	Chr8:114156060-114169919 (-)
LP/J	MGP_LPJ_G0034078	protein coding gene	Chr8:120998196-121010495 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033979	protein coding gene	Chr8:132033765-132046320 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034687	protein coding gene	Chr8:119398814-119411103 (-)
PWK/PhJ	MGP_PWKPhJ_G0032889	protein coding gene	Chr8:114865337-114877712 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032729	protein coding gene	Chr8:118116293-118128513 (-)
WSB/EiJ	MGP_WSBEiJ_G0033303	protein coding gene	Chr8:120106499-120118857 (-)

Human Ortholog

SDR42E1, short chain dehydrogenase/reductase family 42E, member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SDR42E1, short chain dehydrogenase/reductase family 42E, member 1
Synonyms

HSPC105
Links

HGNC:29834

NCBI Gene ID: 93517

UniProt: Q8WUS8
Chr Location

16q23.3; chr16:81988855-82011481 (-) GRCh38

MGI Vertebrate Homology

Sdr42e1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SDR42E1
Gene Tree

Sdr42e1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

884
Tissues

19
cDNA Data

25
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sdr42e1

ZFIN sdr42e1

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All Sequences

43
RefSeq

8
UniProt

2
CCDS

CCDS22701.1

Ensembl

ENSMUSG00000034308 (Evidence)
NCBI Gene

74032

			Length	Strain/Species	Flank
genomic	74032	NCBI Gene Model \| MGI Sequence Detail	12291	C57BL/6J	± kb
transcript	NM_028725	RefSeq \| MGI Sequence Detail	2867	C57BL/6
polypeptide	Q9D665	UniProt \| EBI \| MGI Sequence Detail	394	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032585 short-chain dehydrogenase/reductase family 42E member 1

(term hierarchy)
EC

1.1.1.-
InterPro Domains

IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase

IPR050177 Bifunctional lipid A modification and metabolic enzymes

IPR036291 NAD(P)-binding domain superfamily

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All nucleic 25

cDNA 25

Microarray probesets 3

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MGI:2142464

Summaries

All 30

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:366215 Rudat C, et al., PPARG contributes to urothelial integrity in the murine ureter by activating the expression of Shh and superficial cell-specific genes. Development. 2025 Apr 15;152(8)

TSS for Sdr42e1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83106	Chr8:118400421-118400440 (-)	-3 bp
Tssr83105	Chr8:118400402-118400413 (-)	20 bp
Tssr83104	Chr8:118400371-118400394 (-)	45 bp
Tssr83103	Chr8:118398265-118398294 (-)	2,148 bp
Tssr83102	Chr8:118398240-118398262 (-)	2,177 bp
Tssr83101	Chr8:118397999-118398010 (-)	2,423 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24