Fcho1 MGI Mouse Gene Detail - MGI:1921265

Symbol

Fcho1
Name

FCH domain only 1
Synonyms

3322402E17Rik

Feature Type

protein coding gene
IDs

MGI:1921265
NCBI Gene: 74015
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr8:72161031-72178360 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.43 cM
Mapping Data

3 experiments

SNPs within 2kb

742 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921265	protein coding gene	Chr8:72161031-72181980 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033763	protein coding gene	Chr8:72124567-72141780 (-)
A/J	MGP_AJ_G0033746	protein coding gene	Chr8:69186253-69203582 (-)
AKR/J	MGP_AKRJ_G0033672	protein coding gene	Chr8:71238197-71255422 (-)
BALB/cJ	MGP_BALBcJ_G0033742	protein coding gene	Chr8:69370573-69387786 (-)
C3H/HeJ	MGP_C3HHeJ_G0033452	protein coding gene	Chr8:71806914-71824127 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034260	protein coding gene	Chr8:74869223-74886552 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031202	protein coding gene	Chr8:63818113-63835439 (-)
CAST/EiJ	MGP_CASTEiJ_G0032777	protein coding gene	Chr8:71266214-71283494 (-)
CBA/J	MGP_CBAJ_G0033430	protein coding gene	Chr8:77519935-77537148 (-)
DBA/2J	MGP_DBA2J_G0033584	protein coding gene	Chr8:68910500-68927713 (-)
FVB/NJ	MGP_FVBNJ_G0033526	protein coding gene	Chr8:68011259-68028472 (-)
LP/J	MGP_LPJ_G0033671	protein coding gene	Chr8:72110108-72127321 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033573	protein coding gene	Chr8:80055150-80072479 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034277	protein coding gene	Chr8:71289631-71306844 (-)
PWK/PhJ	MGP_PWKPhJ_G0032484	protein coding gene	Chr8:68200746-68218077 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032321	protein coding gene	Chr8:70245429-70262639 (-)
WSB/EiJ	MGP_WSBEiJ_G0032893	protein coding gene	Chr8:71640881-71658113 (-)

Human Ortholog

FCHO1, FCH and mu domain containing endocytic adaptor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FCHO1, FCH and mu domain containing endocytic adaptor 1
Synonyms

IMD76
Links

HGNC:29002

NCBI Gene ID: 23149

UniProt: O14526
Chr Location

19p13.11; chr19:17747718-17788568 (+) GRCh38

MGI Vertebrate Homology

Fcho1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FCHO1
Gene Tree

Fcho1

Diseases

1 with human FCHO1 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Fcho1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available

less

All GO Annotations

37
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

779
Tissues

12
cDNA Data

51
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fcho1

less

All Sequences

80
RefSeq

24
UniProt

5
CCDS

CCDS52588.1

Ensembl

ENSMUSG00000070000 (Evidence)
NCBI Gene

74015

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070000	Ensembl Gene Model \| MGI Sequence Detail	17330	C57BL/6J	± kb
transcript	ENSMUST00000093444	Ensembl \| MGI Sequence Detail	3073	Not Applicable
polypeptide	ENSMUSP00000091151	Ensembl \| MGI Sequence Detail	873	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000030275 F-BAR domain only protein 1

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR031160 F-BAR domain

IPR001060 FCH domain

IPR042735 FCHo1, F-BAR domain

IPR028565 Mu homology domain

IPR018808 Muniscin, C-terminal
GlyGen

Q8K285 2 sites, 1 N-linked glycan (1 site)

less

All nucleic 51

cDNA 51

Microarray probesets 4

less

MGI:2142889

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Fcho1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81760	Chr8:72178340-72178380 (-)	0 bp
Tssr81759	Chr8:72178294-72178328 (-)	49 bp
Tssr81758	Chr8:72175952-72176001 (-)	2,383 bp
Tssr81757	Chr8:72175931-72175942 (-)	2,423 bp
Tssr81756	Chr8:72174674-72174678 (-)	3,684 bp
Tssr81755	Chr8:72174459-72174463 (-)	3,899 bp
Tssr81754	Chr8:72171871-72171882 (-)	6,483 bp
Tssr81753	Chr8:72169852-72169861 (-)	8,503 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24