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Herc3
Gene Detail
 Symbol
Name
ID
Herc3
hect domain and RLD 3
MGI:1921248
Synonyms 5730409F18Rik, MGC:30404
Feature Type protein coding gene
Genetic Map
Chromosome 6
27.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:58831465-58920398 bp, + strand
From VEGA annotation of GRCm38

  88934 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57095  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: HERC protein
Gene Tree: Herc3

Human
homologs
Human Homolog HERC3, HECT and RLD domain containing E3 ubiquitin protein ligase 3
NCBI Gene ID 8916
neXtProt AC  NX_Q15034
Human Chr (Location)  4q21; chr4:88592423-88708542 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Herc3 interacts with 235 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Component cytoplasm, nucleus
Function ligase activity, ubiquitin-protein transferase activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (129)    Tissues (39)    Images (28)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 129
cDNA source data(79)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) cDNA(79)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017307 (Evidence)
Ensembl Gene ModelENSMUSG00000029804 (Evidence)
Entrez Gene73998 (Evidence)
UniGene191892
DFCITC1575789, TC1589815
DoTSDT.101400688, DT.102542514, DT.40179962, DT.482579
NIA Mouse Gene IndexU042742
Consensus CDS ProjectCCDS20196.1
International Mouse Knockout Project StatusHerc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017307 VEGA Gene Model | MGI Sequence Detail 88934 C57BL/6J ±  kb
transcript OTTMUST00000042010 VEGA | MGI Sequence Detail 4731 Not Applicable 
polypeptide OTTMUSP00000018889 VEGA | MGI Sequence Detail 1050 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(18) UniProt(8)
Polymorphisms SNPs within 2kb(433 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000569 HECT
InterPro IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
InterPro IPR000408 Regulator of chromosome condensation, RCC1
Protein Ontology PR:000032644 probable E3 ubiquitin-protein ligase HERC3
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGI:2141458

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory