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Herc3 Gene Detail
Summary
  • Symbol
    Herc3
  • Name
    hect domain and RLD 3
  • Synonyms
    5730409F18Rik, MGC:30404
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921248
    NCBI Gene: 73998
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:58831465-58920398 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    432 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921248
protein coding gene Chr6:58831454-58920398 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030818
protein coding gene Chr6:58454218-58551976 (+)
A/J MGP_AJ_G0030785
protein coding gene Chr6:55928509-56021210 (+)
AKR/J MGP_AKRJ_G0030713
protein coding gene Chr6:57773988-57862349 (+)
BALB/cJ MGP_BALBcJ_G0030797
protein coding gene Chr6:56216012-56311207 (+)
C3H/HeJ MGP_C3HHeJ_G0030511
protein coding gene Chr6:57750778-57841298 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031255
protein coding gene Chr6:59734575-59839889 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028447
protein coding gene Chr6:52940396-53031443 (+)
CAST/EiJ MGP_CASTEiJ_G0029909
protein coding gene Chr6:57403358-57498910 (+)
CBA/J MGP_CBAJ_G0030484
protein coding gene Chr6:62246444-62340993 (+)
DBA/2J MGP_DBA2J_G0030635
protein coding gene Chr6:55632409-55728362 (+)
FVB/NJ MGP_FVBNJ_G0030588
protein coding gene Chr6:55183194-55271987 (+)
LP/J MGP_LPJ_G0030720
protein coding gene Chr6:58386528-58479893 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030623
protein coding gene Chr6:64904869-64996194 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031281
protein coding gene Chr6:57626626-57726611 (+)
PWK/PhJ MGP_PWKPhJ_G0029624
protein coding gene Chr6:55384658-55474686 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029451
protein coding gene Chr6:56837842-56931338 (+)
WSB/EiJ MGP_WSBEiJ_G0029990
protein coding gene Chr6:57824807-57918261 (+)



Homology
more
  • Human Ortholog
    HERC3, HECT and RLD domain containing E3 ubiquitin protein ligase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HERC3, HECT and RLD domain containing E3 ubiquitin protein ligase 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 8916
    neXtProt AC: NX_Q15034
    UniProt: Q15034

  • Chr Location
    4q22.1; chr4:88592423-88709303 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal hair follicle bulge morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029804 Ensembl Gene Model | MGI Sequence Detail 88934 C57BL/6J ±  kb
    transcript ENSMUST00000041401 Ensembl | MGI Sequence Detail 4731 Not Applicable  
    polypeptide ENSMUSP00000040025 Ensembl | MGI Sequence Detail 1050 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • InterPro Domains
      IPR000569 HECT domain
      IPR035983 HECT, E3 ligase catalytic domain
      IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
      IPR000408 Regulator of chromosome condensation, RCC1
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 80

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141458
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 2
      Gene Ontology 1
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:209956 Liakath-Ali K, et al., Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun. 2014;5:3540

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/14/2019
    MGI 6.14
    The Jackson Laboratory