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Ppp1r42 Gene Detail
Summary
  • Symbol
    Ppp1r42
  • Name
    protein phosphatase 1, regulatory subunit 42
  • Synonyms
    1700011J18Rik, 4930418G15Rik, Lrrc67
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921138
    NCBI Gene: 69312
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:9968624-10009136 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 2.25 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921138
protein coding gene Chr1:9968622-10013541 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015831
protein coding gene Chr1:7233284-7273972 (-)
A/J MGP_AJ_G0015813
protein coding gene Chr1:7289381-7330762 (-)
AKR/J MGP_AKRJ_G0015772
protein coding gene Chr1:7177185-7219865 (-)
BALB/cJ MGP_BALBcJ_G0015769
protein coding gene Chr1:7023385-7063702 (-)
C3H/HeJ MGP_C3HHeJ_G0015603
protein coding gene Chr1:7098238-7143821 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016223
protein coding gene Chr1:7571199-7613519 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013944
protein coding gene Chr1:6126587-6167140 (-)
CAST/EiJ MGP_CASTEiJ_G0015183
protein coding gene Chr1:7293011-7333428 (-)
CBA/J MGP_CBAJ_G0015576
protein coding gene Chr1:7729311-7784669 (-)
DBA/2J MGP_DBA2J_G0015675
protein coding gene Chr1:6908214-6949944 (-)
FVB/NJ MGP_FVBNJ_G0015680
protein coding gene Chr1:6823589-6864595 (-)
LP/J MGP_LPJ_G0015747
protein coding gene Chr1:7447850-7487849 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015699
protein coding gene Chr1:8395583-8440549 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016269
protein coding gene Chr1:7080197-7123990 (-)
PWK/PhJ MGP_PWKPhJ_G0014967
protein coding gene Chr1:6774751-6816198 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014747
protein coding gene Chr1:7247224-7288872 (-)
WSB/EiJ MGP_WSBEiJ_G0015247
protein coding gene Chr1:7110744-7157709 (-)



Homology
more
  • Human Ortholog
    PPP1R42, protein phosphatase 1 regulatory subunit 42
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPP1R42, protein phosphatase 1 regulatory subunit 42
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dtr, LRRC67, TLLR, TLRR
  • Links
    NCBI Gene ID: 286187
    neXtProt AC: NX_Q7Z4L9
    UniProt: Q7Z4L9

  • Chr Location
    8q13.1; chr8:66988131-67028551 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025916 Ensembl Gene Model | MGI Sequence Detail 40513 C57BL/6J ±  kb
    transcript ENSMUST00000027049 Ensembl | MGI Sequence Detail 1425 Not Applicable  
    polypeptide ENSMUSP00000027049 Ensembl | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR025875 Leucine rich repeat 4
      IPR032675 Leucine-rich repeat domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916562
    References
    more
    • Summaries
      All 23
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:174423 Wang R, et al., PP1 Forms an Active Complex with TLRR (lrrc67), a Putative PP1 Regulatory Subunit, during the Early Stages of Spermiogenesis in Mice. PLoS One. 2011;6(6):e21767

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/19/2019
    MGI 6.13
    The Jackson Laboratory