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Fam161a
Gene Detail
Symbol

Name
ID
Fam161a
family with sequence similarity 161, member A
MGI:1921123
Synonyms
4930430E16Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
14.25 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:23007531-23030788 bp, + strand
From VEGA annotation of GRCm38

  23258 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19131  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FAM161A
Gene Tree: Fam161a

Human
homologs
FAM161A, family with sequence similarity 161, member A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 84140
neXtProt AC: NX_Q3B820

Human Synonyms: RP28

Human Chr (Location): 2p15; chr2:61744556-61855402 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FAM161A

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele show early loss of visual function associated with alterations in photoreceptor ciliary structure, abnormal photoreceptor outer segment morphology, microgliosis, and progressive retinal photoreceptor degeneration.
 
Interactions
Fam161a interacts with 240 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell projection organization, cilium assembly, ...
Component cell projection, centrosome, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (64)    Tissues (14)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 64
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fam161a    NEW 
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005271 (Evidence)
Ensembl Gene Model ENSMUSG00000049811 (Evidence)
Entrez Gene 73873 (Evidence)
UniGene 252406
DFCI TC1687151, TC1608924, TC1584928
DoTS DT.97393795, DT.94294216, DT.91348876, DT.91335104, DT.103561014, DT.101347555
NIA Mouse Gene Index U012375
Consensus CDS Project CCDS48757.1
International Mouse Phenotyping Consortium Status Fam161a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005271 VEGA Gene Model | MGI Sequence Detail 23258 C57BL/6J ±  kb
transcript OTTMUST00000096135 VEGA | MGI Sequence Detail 1935 Not Applicable 
polypeptide OTTMUSP00000053674 VEGA | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(30) UniProt(6)
Polymorphisms
SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019579 Uncharacterised protein family UPF0564
Protein Ontology PR:000030937 protein FAM161A
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:214319 Karlstetter M, et al., Disruption of the retinitis pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive retinal degeneration. Hum Mol Genet. 2014 Oct 1;23(19):5197-210
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory