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Fam161a Gene Detail
Summary
  • Symbol
    Fam161a
  • Name
    family with sequence similarity 161, member A
  • Synonyms
    4930430E16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921123
    NCBI Gene: 73873
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:23007531-23030788 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 14.25 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921123
protein coding gene Chr11:23006692-23045743 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018084
protein coding gene Chr11:20722237-20746011 (+)
A/J MGP_AJ_G0018057
protein coding gene Chr11:19932634-19956698 (+)
AKR/J MGP_AKRJ_G0018021
protein coding gene Chr11:20646243-20669366 (+)
BALB/cJ MGP_BALBcJ_G0018025
protein coding gene Chr11:20068040-20092047 (+)
C3H/HeJ MGP_C3HHeJ_G0017839
protein coding gene Chr11:20521349-20547004 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018477
protein coding gene Chr11:21577060-21600882 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016135
protein coding gene Chr11:18834336-18858020 (+)
CAST/EiJ MGP_CASTEiJ_G0017400
protein coding gene Chr11:20575995-20601798 (+)
CBA/J MGP_CBAJ_G0017813
protein coding gene Chr11:22533257-22556832 (+)
DBA/2J MGP_DBA2J_G0017923
protein coding gene Chr11:19863013-19885880 (+)
FVB/NJ MGP_FVBNJ_G0017915
protein coding gene Chr11:19639480-19662247 (+)
LP/J MGP_LPJ_G0017994
protein coding gene Chr11:20837160-20860250 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017941
protein coding gene Chr11:23006198-23030572 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018518
protein coding gene Chr11:20754205-20779584 (+)
PWK/PhJ MGP_PWKPhJ_G0017181
protein coding gene Chr11:19897561-19922494 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016978
protein coding gene Chr11:20495153-20524549 (+)
WSB/EiJ MGP_WSBEiJ_G0017454
protein coding gene Chr11:20379276-20402921 (+)



Homology
more
  • Human Ortholog
    FAM161A, FAM161A, centrosomal protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAM161A, FAM161A, centrosomal protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RP28
  • Links
    NCBI Gene ID: 84140
    neXtProt AC: NX_Q3B820
    UniProt: Q3B820

  • Chr Location
    2p15; chr2:61800240-61856074 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Fam161a mouse models; 1 with human FAM161A associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele show early loss of visual function associated with alterations in photoreceptor ciliary structure, abnormal photoreceptor outer segment morphology, microgliosis, and progressive retinal photoreceptor degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049811 Ensembl Gene Model | MGI Sequence Detail 23258 C57BL/6J ±  kb
    transcript ENSMUST00000208732 Ensembl | MGI Sequence Detail 2034 Not Applicable  
    polypeptide ENSMUSP00000146368 Ensembl | MGI Sequence Detail 562 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR019579 Uncharacterised protein family UPF0564
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 4
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory