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Man2c1 Gene Detail
Summary
  • Symbol
    Man2c1
  • Name
    mannosidase, alpha, class 2C, member 1
  • Synonyms
    1110025H24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920994
    NCBI Gene: 73744
Location & Maps
more
  • Sequence Map
    Chr9:57130690-57142722 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12033 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 30.89 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MAN2C1, mannosidase alpha class 2C member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAN2C1, mannosidase alpha class 2C member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MAN6A8, MANA, MANA1
  • Links
    NCBI Gene ID: 4123
    neXtProt AC: NX_Q9NTJ4

  • Chr Location
    15q24.2; chr15:75355792-75369114 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Germ line null mutants display neuronal and glia degeneration, glycogen accumulation, and liver and kidney damage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033295 VEGA Gene Model | MGI Sequence Detail 12033 C57BL/6J ±  kb
transcript OTTMUST00000083515 VEGA | MGI Sequence Detail 3820 Not Applicable  
polypeptide OTTMUSP00000044899 VEGA | MGI Sequence Detail 1039 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    61 from dbSNP Build 142
Protein
Information
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  • UniProt
    17 Sequences
  • Protein Ontology
    PR:000010109 alpha-mannosidase 2C1
  • EC
  • InterPro Domains
    IPR011013 Galactose mutarotase-like domain
    IPR027291 Glycoside hydrolase 38/57, N-terminal domain
    IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
    IPR028995 Glycoside hydrolase families 57/38, central domain
    IPR015341 Glycoside hydrolase family 38, central domain
    IPR000602 Glycoside hydrolase family 38, N-terminal domain
    IPR011682 Glycosyl hydrolase family 38, C-terminal
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 4
References
more
  • Summaries
    All 28
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:205550 Paciotti S, et al., Accumulation of free oligosaccharides and tissue damages in cytosolic alpha-mannosidase (Man2c1) deficient mice. J Biol Chem. 2014 Feb 18;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory