About   Help   FAQ
Man2c1 Gene Detail
Summary
  • Symbol
    Man2c1
  • Name
    mannosidase, alpha, class 2C, member 1
  • Synonyms
    1110025H24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920994
    NCBI Gene: 73744
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57130690-57142722 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 30.89 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920994
protein coding gene Chr9:57130149-57142722 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034859
protein coding gene Chr9:56299750-56311712 (+)
A/J MGP_AJ_G0034840
protein coding gene Chr9:54487729-54500385 (+)
AKR/J MGP_AKRJ_G0034769
protein coding gene Chr9:55744801-55758473 (+)
BALB/cJ MGP_BALBcJ_G0034832
protein coding gene Chr9:54289759-54302084 (+)
C3H/HeJ MGP_C3HHeJ_G0034542
protein coding gene Chr9:56218401-56231316 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035351
protein coding gene Chr9:57889528-57901513 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032262
protein coding gene Chr9:53827106-53839286 (+)
CAST/EiJ MGP_CASTEiJ_G0033863
protein coding gene Chr9:56300167-56312165 (+)
CBA/J MGP_CBAJ_G0034513
protein coding gene Chr9:59908380-59922451 (+)
DBA/2J MGP_DBA2J_G0034672
protein coding gene Chr9:54369343-54381324 (+)
FVB/NJ MGP_FVBNJ_G0034614
protein coding gene Chr9:53591520-53603861 (+)
LP/J MGP_LPJ_G0034755
protein coding gene Chr9:56593358-56605343 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034657
protein coding gene Chr9:61378861-61399014 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035373
protein coding gene Chr9:55760739-55774517 (+)
PWK/PhJ MGP_PWKPhJ_G0033568
protein coding gene Chr9:54398568-54411041 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033402
protein coding gene Chr9:56053545-56066279 (+)
WSB/EiJ MGP_WSBEiJ_G0033976
protein coding gene Chr9:55698190-55711852 (+)



Homology
more
  • Human Ortholog
    MAN2C1, mannosidase alpha class 2C member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAN2C1, mannosidase alpha class 2C member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAN6A8, MANA, MANA1
  • Links
    NCBI Gene ID: 4123
    neXtProt AC: NX_Q9NTJ4
    UniProt: Q9NTJ4

  • Chr Location
    15q24.2; chr15:75355792-75368680 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Germ line null mutants display neuronal and glia degeneration, glycogen accumulation, and liver and kidney damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032295 Ensembl Gene Model | MGI Sequence Detail 12033 C57BL/6J ±  kb
transcript ENSMUST00000160147 Ensembl | MGI Sequence Detail 3820 Not Applicable  
polypeptide ENSMUSP00000125478 Ensembl | MGI Sequence Detail 1039 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    17 Sequences
  • Protein Ontology
    PR:000010109 alpha-mannosidase 2C1
  • EC
  • InterPro Domains
    IPR011013 Galactose mutarotase-like domain superfamily
    IPR027291 Glycoside hydrolase 38, N-terminal domain superfamily
    IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
    IPR028995 Glycoside hydrolase families 57/38, central domain superfamily
    IPR015341 Glycoside hydrolase family 38, central domain
    IPR037094 Glycoside hydrolase family 38, central domain superfamily
    IPR000602 Glycoside hydrolase family 38, N-terminal domain
    IPR011682 Glycosyl hydrolase family 38, C-terminal
    IPR041147 Glycosyl hydrolases family 38, C-terminal beta sandwich domain
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
References
more
  • Summaries
    All 28
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:205550 Paciotti S, et al., Accumulation of free oligosaccharides and tissue damage in cytosolic alpha-mannosidase (Man2c1)-deficient mice. J Biol Chem. 2014 Apr 4;289(14):9611-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory