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Lima1 Gene Detail
Summary
  • Symbol
    Lima1
  • Name
    LIM domain and actin binding 1
  • Synonyms
    1110021C24Rik, 3526402A12Rik, epithelial protein lost in neoplasm, EPLIN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920992
    NCBI Gene: 65970
  • Gene Overview
    MyGene.info: LIMA1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr15:99778470-99875428 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      96959 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.13 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LIMA1, LIM domain and actin binding 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LIMA1, LIM domain and actin binding 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPLIN, SREBP3
  • Links
    NCBI Gene ID: 51474
    neXtProt AC: NX_Q9UHB6
    UniProt: Q9UHB6

  • Chr Location
    12q13.12; chr12:50175780-50283570 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 9484
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LIMA1
  • Gene Tree
    Lima1
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    69
  • Tissues
    38
  • cDNA Data
    18
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000036466 VEGA Gene Model | MGI Sequence Detail 96959 C57BL/6J ±  kb
    transcript OTTMUST00000093451 VEGA | MGI Sequence Detail 4215 Not Applicable  
    polypeptide OTTMUSP00000051823 VEGA | MGI Sequence Detail 753 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      690 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 18
      Primer pair 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1196235, MGI:2443059
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 34
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:255082 Kurogi S, et al., Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Sci Rep. 2017 Jan 20;7:40692
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory