About   Help   FAQ
Kprp Gene Detail
Summary
  • Symbol
    Kprp
  • Name
    keratinocyte expressed, proline-rich
  • Synonyms
    1110001M24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920981
    NCBI Gene: 433619
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:92823074-92827247 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.14 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920981
protein coding gene Chr3:92823074-92827247 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027519
protein coding gene Chr3:93284921-93289136 (-)
A/J MGP_AJ_G0027486
protein coding gene Chr3:90349465-90353680 (-)
AKR/J MGP_AKRJ_G0027451
protein coding gene Chr3:92469271-92473444 (-)
BALB/cJ MGP_BALBcJ_G0027494
protein coding gene Chr3:90159108-90163323 (-)
C3H/HeJ MGP_C3HHeJ_G0027232
protein coding gene Chr3:92683522-92687737 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027936
protein coding gene Chr3:96837448-96841621 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025285
protein coding gene Chr3:86974545-86978757 (-)
CAST/EiJ MGP_CASTEiJ_G0026679
protein coding gene Chr3:92109307-92113527 (-)
CBA/J MGP_CBAJ_G0027208
protein coding gene Chr3:100154905-100159120 (-)
DBA/2J MGP_DBA2J_G0027345
protein coding gene Chr3:89676133-89680306 (-)
FVB/NJ MGP_FVBNJ_G0027313
protein coding gene Chr3:87839241-87843414 (-)
LP/J MGP_LPJ_G0027453
protein coding gene Chr3:94505574-94509789 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027339
protein coding gene Chr3:106457559-106461773 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027996
protein coding gene Chr3:92199036-92203251 (-)
PWK/PhJ MGP_PWKPhJ_G0026410
protein coding gene Chr3:89554380-89558593 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026231
protein coding gene Chr3:90535291-90539620 (-)
WSB/EiJ MGP_WSBEiJ_G0026762
protein coding gene Chr3:92571239-92575453 (-)



Homology
more
  • Human Ortholog
    KPRP, keratinocyte proline rich protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KPRP, keratinocyte proline rich protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf45
  • Links
    NCBI Gene ID: 448834
    neXtProt AC: NX_Q5T749
    UniProt: Q5T749

  • Chr Location
    1q21.3; chr1:152758030-152762053 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a null allele show a thin stratum granulosum, detachment of lower layers of the stratum corneum, abnormal desmosome structure and enhanced percutaneous immune responses to irritants and allergens. Homozygotes show a similar phenotype as heterozygotes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 433619 NCBI Gene Model | MGI Sequence Detail 4174 C57BL/6J ±  kb
    transcript NM_028629 RefSeq | MGI Sequence Detail 2738 C57BL/6  
    polypeptide B2RUR4 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139600
    References
    more
    • Summaries
      All 29
      Diseases 1
      Gene Ontology 1
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:286659 Suga H, et al., Keratinocyte Proline-Rich Protein Deficiency in Atopic Dermatitis Leads to Barrier Disruption. J Invest Dermatol. 2019 Sep;139(9):1867-1875.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    02/23/2021
    MGI 6.16
    The Jackson Laboratory