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Mcee Gene Detail
Summary
  • Symbol
    Mcee
  • Name
    methylmalonyl CoA epimerase
  • Synonyms
    1110007A04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920974
    NCBI Gene: 73724
Location & Maps
more
  • Sequence Map
    Chr7:64392607-64412125 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19519 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 34.65 cM, cytoband C
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MCEE, methylmalonyl-CoA epimerase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCEE, methylmalonyl-CoA epimerase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GLOD2
  • Links
    NCBI Gene ID: 84693
    neXtProt AC: NX_Q96PE7

  • Chr Location
    2p13.3; chr2:71109676-71130288 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 13078
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MCEE
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MCEE associations

Human Disease Mouse Models
       Methylmalonyl-Coa Epimerase Deficiency   OMIM: 251120
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Mcee
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027294 VEGA Gene Model | MGI Sequence Detail 19519 C57BL/6J ±  kb
transcript OTTMUST00000067459 VEGA | MGI Sequence Detail 828 Not Applicable  
polypeptide OTTMUSP00000033953 VEGA | MGI Sequence Detail 178 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    199 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010235 methylmalonyl-CoA epimerase, mitochondrial
  • EC
  • InterPro Domains
    IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
    IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
    IPR017515 Methylmalonyl-CoA epimerase
Molecular
Reagents
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  • All nucleic 32
    cDNA 32

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory