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Rbm20 Gene Detail
Summary
  • Symbol
    Rbm20
  • Name
    RNA binding motif protein 20
  • Synonyms
    1110018J23Rik, 2010003H22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920963
    NCBI Gene: 73713
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:53677306-53867080 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 48.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1401 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920963
protein coding gene Chr19:53660989-53867083 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025249
protein coding gene Chr19:53839119-54045397 (+)
A/J MGP_AJ_G0025225
protein coding gene Chr19:51187105-51382673 (+)
AKR/J MGP_AKRJ_G0025194
protein coding gene Chr19:52799909-53006696 (+)
BALB/cJ MGP_BALBcJ_G0025220
protein coding gene Chr19:51270198-51469156 (+)
C3H/HeJ MGP_C3HHeJ_G0024980
protein coding gene Chr19:53014007-53223985 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025663
protein coding gene Chr19:55140903-55347587 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023075
protein coding gene Chr19:50178045-50372112 (+)
CAST/EiJ MGP_CASTEiJ_G0024445
protein coding gene Chr19:52986124-53191248 (+)
CBA/J MGP_CBAJ_G0024960
protein coding gene Chr19:57869771-58103490 (+)
DBA/2J MGP_DBA2J_G0025092
protein coding gene Chr19:50995807-51193786 (+)
FVB/NJ MGP_FVBNJ_G0025053
protein coding gene Chr19:50708092-50909445 (+)
LP/J MGP_LPJ_G0025178
protein coding gene Chr19:53721983-53933975 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025086
protein coding gene Chr19:57319950-57532414 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025721
protein coding gene Chr19:52996410-53200590 (+)
PWK/PhJ MGP_PWKPhJ_G0024193
protein coding gene Chr19:50898650-51103799 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023996
protein coding gene Chr19:51660335-51864847 (+)
WSB/EiJ MGP_WSBEiJ_G0024515
protein coding gene Chr19:53125509-53328746 (+)



Homology
more
  • Human Ortholog
    RBM20, RNA binding motif protein 20
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RBM20, RNA binding motif protein 20
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 282996
    neXtProt AC: NX_Q5T481
    UniProt: Q5T481

  • Chr Location
    10q25.2; chr10:110641934-110839471 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 28386
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RBM20
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human RBM20 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an allele lacking the RNA recognition motif exhibit increased titin compliance, and attenuated Frank-Starling mechanism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043639 Ensembl Gene Model | MGI Sequence Detail 189775 C57BL/6J ±  kb
    transcript ENSMUST00000164202 Ensembl | MGI Sequence Detail 6592 Not Applicable  
    polypeptide ENSMUSP00000129447 Ensembl | MGI Sequence Detail 1199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917122, MGI:2147587
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:237830 Methawasin M, et al., Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction. Circulation. 2016 Oct 11;134(15):1085-1099

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory