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Rbm20
Gene Detail
Symbol

Name
ID
Rbm20
RNA binding motif protein 20
MGI:1920963
Synonyms
1110018J23Rik, 2010003H22Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
48.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:53677306-53867080 bp, + strand
From VEGA annotation of GRCm38

  189775 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:28386  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RBM20
Gene Tree: Rbm20

Human
homologs
RBM20, RNA binding motif protein 20
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 282996
neXtProt AC: NX_Q5T481

Human Chr (Location): 10q25.2; chr10:110644397-110839471 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RBM20

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an allele lacking the RNA recognition motif exhibit increased titin compliance, and attenuated Frank-Starling mechanism.
 
Interactions
Rbm20 interacts with 295 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process heart development, mRNA processing, ...
Component nucleus
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (106)    Tissues (11)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA RBM20 ; Xenbase rbm20 ; ZFIN rbm20    NEW 
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033320 (Evidence)
Ensembl Gene Model ENSMUSG00000043639 (Evidence)
Entrez Gene 73713 (Evidence)
UniGene 313695
DFCI TC1643839, TC1607841, TC1658060, TC1631269
DoTS DT.485144, DT.101125793
Consensus CDS Project CCDS50468.1
International Mouse Phenotyping Consortium Status Rbm20
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033320 VEGA Gene Model | MGI Sequence Detail 189775 C57BL/6J ±  kb
transcript OTTMUST00000083603 VEGA | MGI Sequence Detail 2529 Not Applicable 
polypeptide OTTMUSP00000044954 VEGA | MGI Sequence Detail 809 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(13) UniProt(3)
Polymorphisms
SNPs within 2kb(1413 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR000690 Zinc finger, C2H2-type matrin
InterPro IPR003604 Zinc finger, U1-type
Protein Ontology PR:000031033 RNA-binding protein 20
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210662 Beraldi R, et al., Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy. Hum Mol Genet. 2014 Jul 15;23(14):3779-91
All references(34)
Other
accession IDs
MGI:1917122, MGI:2147587

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory