About   Help   FAQ
Tubb2b Gene Detail
Summary
  • Symbol
    Tubb2b
  • Name
    tubulin, beta 2B class IIB
  • Synonyms
    2410129E14Rik, brdp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920960
    NCBI Gene: 73710
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:34127008-34130354 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 14.04 cM, cytoband A4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920960
protein coding gene Chr13:34126748-34130466 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020448
protein coding gene Chr13:32238388-32240373 (-)
A/J MGP_AJ_G0020402
protein coding gene Chr13:31292738-31299568 (-)
AKR/J MGP_AKRJ_G0020380
protein coding gene Chr13:32035335-32038355 (-)
BALB/cJ MGP_BALBcJ_G0020397
protein coding gene Chr13:31362810-31366442 (-)
C3H/HeJ MGP_C3HHeJ_G0020196
protein coding gene Chr13:31970949-31979783 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021054
protein coding gene Chr13:64963092-64965116 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0019931
protein coding gene Chr13:62201615-62203189 (-)
CBA/J MGP_CBAJ_G0020157
protein coding gene Chr13:34763212-34765690 (-)
DBA/2J MGP_DBA2J_G0020279
protein coding gene Chr13:30824536-30827575 (-)
FVB/NJ MGP_FVBNJ_G0020259
protein coding gene Chr13:30394837-30400977 (-)
LP/J MGP_LPJ_G0020355
protein coding gene Chr13:32473008-32477759 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019458
protein coding gene Chr12:9887253-9888579 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0019685
protein coding gene Chr13:60031981-60033555 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0019774
protein coding gene Chr13:32050652-32052820 (-)



Homology
more
  • Human Ortholog
    TUBB2B, tubulin beta 2B class IIb
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TUBB2B, tubulin beta 2B class IIb
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bA506K6.1, CDCBM7, PMGYSA
  • Links
    NCBI Gene ID: 347733
    neXtProt AC: NX_Q9BVA1
    UniProt: Q9BVA1

  • Chr Location
    6p25.2; chr6:3224261-3227734 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 49734
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TUBB2B
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Tubb2b mouse models; 1 with human TUBB2B associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit mild hydroencephaly, telencephalon dysmorphology, a small olfactory bulb and prenatal lethality. Mice heterozygous for this mutation exhibit hyperactivity, reduced fertility and abnormal cortex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73710 NCBI Gene Model | MGI Sequence Detail 3347 C57BL/6J ±  kb
    transcript NM_023716 RefSeq | MGI Sequence Detail 1922 C57BL/6  
    polypeptide Q9CWF2 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5056355
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:262218 Stottmann RW, et al., A heterozygous mutation in tubulin, beta 2B ( Tubb2b ) causes cognitive deficits and hippocampal disorganization. Genes Brain Behav. 2017 Feb;16(2):250-259

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory