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Tubb2b Gene Detail
Summary
  • Symbol
    Tubb2b
  • Name
    tubulin, beta 2B class IIB
  • Synonyms
    2410129E14Rik, brdp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920960
    NCBI Gene: 73710
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:34310991-34314337 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 14.04 cM, cytoband A4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920960
 protein coding gene Chr13:34310731-34314449 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020448
 protein coding gene Chr13:32238388-32240373 (-)
A/J MGP_AJ_G0020402
 protein coding gene Chr13:31292738-31299568 (-)
AKR/J MGP_AKRJ_G0020380
 protein coding gene Chr13:32035335-32038355 (-)
BALB/cJ MGP_BALBcJ_G0020397
 protein coding gene Chr13:31362810-31366442 (-)
C3H/HeJ MGP_C3HHeJ_G0020196
 protein coding gene Chr13:31970949-31979783 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021054
 protein coding gene Chr13:64963092-64965116 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0019931
 protein coding gene Chr13:62201615-62203189 (-)
CBA/J MGP_CBAJ_G0020157
 protein coding gene Chr13:34763212-34765690 (-)
DBA/2J MGP_DBA2J_G0020279
 protein coding gene Chr13:30824536-30827575 (-)
FVB/NJ MGP_FVBNJ_G0020259
 protein coding gene Chr13:30394837-30400977 (-)
LP/J MGP_LPJ_G0020355
 protein coding gene Chr13:32473008-32477759 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019458
 protein coding gene Chr12:9887253-9888579 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0019685
 protein coding gene Chr13:60031981-60033555 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0019774
 protein coding gene Chr13:32050652-32052820 (-)



Homology
more
  • Human Ortholog
    TUBB2B, tubulin beta 2B class IIb
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBB2B, tubulin beta 2B class IIb
  • Synonyms
    bA506K6.1, CDCBM7, PMGYSA
  • Links
    NCBI Gene ID: 347733
    neXtProt AC: NX_Q9BVA1
    UniProt: Q9BVA1

  • Chr Location
    6p25.2; chr6:3223324-3231730 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tubb2b mouse models; 1 with human TUBB2B associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 6 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit mild hydroencephaly, telencephalon dysmorphology, a small olfactory bulb and prenatal lethality. Mice heterozygous for this mutation exhibit hyperactivity, reduced fertility and abnormal cortex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    45
  • cDNA Data
    6
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73710 NCBI Gene Model | MGI Sequence Detail 3347 C57BL/6J ±  kb
    transcript NM_023716 RefSeq | MGI Sequence Detail 1922 C57BL/6  
    polypeptide Q9CWF2 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5056355
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:326570 Niu W, et al., Mouse oocytes develop in cysts with the help of nurse cells. Cell. 2022 Jul 7;185(14):2576-2590.e12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory