About   Help   FAQ
Tubb2b
Gene Detail
Symbol

Name
ID
Tubb2b
tubulin, beta 2B class IIB
MGI:1920960
Synonyms
2410129E14Rik, brdp
Feature Type
protein coding gene
Genetic Map
Chromosome 13
14.04 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:34127008-34130354 bp, - strand
From NCBI annotation of GRCm38

  3347 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49734  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TUBB2B
Gene Tree: Tubb2b

Human
homologs
TUBB2B, tubulin, beta 2B class IIb
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 347733
neXtProt AC: NX_Q9BVA1

Human Synonyms: bA506K6.1, PMGYSA

Human Chr (Location): 6p25; chr6:3224261-3231665 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TUBB2B

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(2) Radiation induced(1) Targeted(3)
Genomic Mutations involving Tubb2b (1)
Incidental mutations (data from APF )
 
Mice homozygous for an ENU-induced mutation exhibit mild hydroencephaly, telencephalon dysmorphology, a small olfactory bulb and prenatal lethality. Mice heterozygous for this mutation exhibit hyperactivity, reduced fertility and abnormal cortex.
 
Human Diseases Modeled in Mice Using Tubb2b (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tubb2b interacts with 81 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process microtubule-based process, neuron migration, ...
Component cytoplasm, cytoskeleton, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (32)    Tissues (31)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
RT-PCR 29
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tubb2b    NEW 
Molecular
reagents
All nucleic(8) cDNA(6) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000045136 (Evidence)
Entrez Gene 73710 (Evidence)
DFCI TC1573221
DoTS DT.101133681, DT.91439211
NIA Mouse Gene Index U013761, U324822, U332812
Consensus CDS Project CCDS26445.1
International Mouse Phenotyping Consortium Status Tubb2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 73710 NCBI Gene Model | MGI Sequence Detail 3347 C57BL/6J ±  kb
transcript NM_023716 RefSeq | MGI Sequence Detail 1922 C57BL/6 
polypeptide Q9CWF2 UniProt | EBI | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)    SNPs within 2kb including multiple locations(70)
Protein-related
information
ResourceIDDescription
InterPro IPR002453 Beta tubulin
InterPro IPR013838 Beta tubulin, autoregulation binding site
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016817 tubulin beta-2B chain
Graphical View of Protein Domain Structure
References
(Earliest) J:64688 Arden SD, et al., Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes. 1999 Mar;48(3):531-42
(Latest) J:201099 Stottmann RW, et al., A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse. Hum Mol Genet. 2013 Oct 15;22(20):4053-63
All references(35)
Disease annotation references (1)
Other
accession IDs
MGI:5056355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory