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Tubb2b Gene Detail
Summary
  • Symbol
    Tubb2b
  • Name
    tubulin, beta 2B class IIB
  • Synonyms
    2410129E14Rik, brdp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920960
    NCBI Gene: 73710
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:34127008-34130354 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3347 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 14.04 cM, cytoband A4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TUBB2B, tubulin beta 2B class IIb
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TUBB2B, tubulin beta 2B class IIb
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA506K6.1, CDCBM7, PMGYSA
  • Links
    NCBI Gene ID: 347733
    neXtProt AC: NX_Q9BVA1
    UniProt: Q9BVA1

  • Chr Location
    6p25.2; chr6:3224261-3227734 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 49734
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TUBB2B
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Tubb2b mouse models; 1 with human TUBB2B associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit mild hydroencephaly, telencephalon dysmorphology, a small olfactory bulb and prenatal lethality. Mice heterozygous for this mutation exhibit hyperactivity, reduced fertility and abnormal cortex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73710 NCBI Gene Model | MGI Sequence Detail 3347 C57BL/6J ±  kb
    transcript NM_023716 RefSeq | MGI Sequence Detail 1922 C57BL/6  
    polypeptide Q9CWF2 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      58 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5056355
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:262218 Stottmann RW, et al., A heterozygous mutation in tubulin, beta 2B ( Tubb2b ) causes cognitive deficits and hippocampal disorganization. Genes Brain Behav. 2017 Feb;16(2):250-259

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory