Tubb2b
Gene Detail

Symbol Name ID

Tubb2b tubulin, beta 2B class IIB MGI:1920960

Synonyms

2410129E14Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 13

14.04 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr13:34127008-34130354 bp, - strand From NCBI annotation of GRCm38   3347 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49734  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Tubb2b

Human homologs

Human Homolog		TUBB2B, tubulin, beta 2B class IIb
NCBI Gene ID		347733
neXtProt AC		NX_Q9BVA1
Human Synonyms		bA506K6.1, PMGYSA
Human Chr (Location)		6p25; chr6:3224495-3227968 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TUBB2B

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	GTP catabolic process, microtubule-based process, ...
Component	cytoplasm, cytoskeleton, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (32)    Tissues (30)    Images (1)
Theiler Stages: 17, 18, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	3
RT-PCR	29

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(6) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000045136 (Evidence)
Entrez Gene	73710 (Evidence)
DFCI	TC1573221
DoTS	DT.101133681, DT.91439211
NIA Mouse Gene Index	U013761, U324822, U332812
Consensus CDS Project	CCDS26445.1
International Mouse Knockout Project Status	Tubb2b

Sequences

Length	Strain/Species
genomic	73710	NCBI Gene Model | MGI Sequence Detail	3347	C57BL/6J
transcript	NM_023716	RefSeq | MGI Sequence Detail	1922	C57BL/6
polypeptide	Q9CWF2	UniProt | EBI | MGI Sequence Detail	445	Not Applicable

All sequences(22) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(62 from dbSNP Build 137)    SNPs within 2kb including multiple locations(70)

Protein-related information

Resource	ID	Description
InterPro	IPR002453	Beta tubulin
InterPro	IPR013838	Beta tubulin, autoregulation binding site
InterPro	IPR000217	Tubulin
InterPro	IPR017975	Tubulin, conserved site
InterPro	IPR023123	Tubulin, C-terminal
InterPro	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain
InterPro	IPR008280	Tubulin/FtsZ, C-terminal
InterPro	IPR003008	Tubulin/FtsZ, GTPase domain
Protein Ontology	PR:000016817	tubulin beta-2B chain

Graphical View of Protein Domain Structure

References

(Earliest) J:64688 Arden SD, et al., Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes. 1999 Mar;48(3):531-42
(Latest) J:175014 Guzun R, et al., Mitochondria-cytoskeleton interaction: Distribution of beta-tubulins in cardiomyocytes and HL-1 cells. Biochim Biophys Acta. 2011 Apr;1807(4):458-69
All references(32)