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Tubb2b
Gene Detail
Symbol

Name
ID
Tubb2b
tubulin, beta 2B class IIB
MGI:1920960
Synonyms
2410129E14Rik, brdp
Feature Type
protein coding gene
Genetic Map
Chromosome 13
14.04 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:34127008-34130354 bp, - strand
From NCBI annotation of GRCm38

  3347 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49734  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tubb2b

Human
homologs
Human Homolog TUBB2B, tubulin, beta 2B class IIb
NCBI Gene ID 347733
neXtProt AC  NX_Q9BVA1
Human Synonyms  bA506K6.1, PMGYSA
Human Chr (Location)  6p25; chr6:3224261-3227734 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TUBB2B
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for an ENU-induced mutation exhibit mild hydroencephaly, telencephalon dysmorphology, a small olfactory bulb and prenatal lethality. Mice heterozygous for this mutation exhibit hyperactivity, reduced fertility and abnormal cortex.
 
Human Diseases Modeled Using Mouse Tubb2b (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tubb2b interacts with 81 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process GTP catabolic process, microtubule-based process, ...
Component cytoplasm, cytoskeleton, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (32)    Tissues (31)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
RT-PCR 29
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(6) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000045136 (Evidence)
Entrez Gene73710 (Evidence)
DFCITC1573221
DoTSDT.91439211, DT.101133681
NIA Mouse Gene IndexU332812, U324822, U013761
Consensus CDS ProjectCCDS26445.1
International Mouse Knockout Project StatusTubb2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 73710 NCBI Gene Model | MGI Sequence Detail 3347 C57BL/6J ±  kb
transcript NM_023716 RefSeq | MGI Sequence Detail 1922 C57BL/6 
polypeptide Q9CWF2 UniProt | EBI | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)    SNPs within 2kb including multiple locations(70)
Protein-related
information
ResourceIDDescription
InterPro IPR002453 Beta tubulin
InterPro IPR013838 Beta tubulin, autoregulation binding site
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016817 tubulin beta-2B chain
Graphical View of Protein Domain Structure
References
(Earliest) J:64688 Arden SD, et al., Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes. 1999 Mar;48(3):531-42
(Latest) J:201099 Stottmann RW, et al., A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse. Hum Mol Genet. 2013 Oct 15;22(20):4053-63
All references(36)
Disease annotation references (1)
Other
accession IDs
MGI:5056355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory