Ppp2r1b
Gene Detail

Symbol Name ID

Ppp2r1b protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform MGI:1920949

Synonyms

2410091N08Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 9

27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:50845301-50894229 bp, + strand From VEGA annotation of GRCm38   48929 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:70244  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: serine/threonine-protein phosphataser PP2A regulatory subunit A
Gene Tree: Ppp2r1b

Human homologs

Human Homolog		PPP2R1B, protein phosphatase 2, regulatory subunit A, beta
NCBI Gene ID		5519
neXtProt AC		NX_P30154
Human Synonyms		PP2A-Abeta, PR65B
Human Chr (Location)		11q23.2; chr11:111597632-111637169 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PPP2R1B

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Component	cellular_component
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (81)    Tissues (31)    Images (23)
Theiler Stages: 23, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	64
Western blot	4
RT-PCR	8

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000037681 (Evidence)
Ensembl Gene Model	ENSMUSG00000032058 (Evidence)
Entrez Gene	73699 (Evidence)
NIA Mouse Gene Index	U010472
Consensus CDS Project	CCDS40625.1, CCDS40626.1
International Mouse Knockout Project Status	Ppp2r1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037681	VEGA Gene Model | MGI Sequence Detail	48929	C57BL/6J
transcript	OTTMUST00000097364	VEGA | MGI Sequence Detail	2195	Not Applicable
polypeptide	OTTMUSP00000054606	VEGA | MGI Sequence Detail	694	Not Applicable

All sequences(73) RefSeq(4) UniProt(10)

Polymorphisms

SNPs(169 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR000357	HEAT
InterPro	IPR021133	HEAT, type 2
Protein Ontology	PR:000013135	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)

Other accession IDs

MGI:2143121