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Thoc3 Gene Detail
Summary
  • Symbol
    Thoc3
  • Name
    THO complex 3
  • Synonyms
    2410044K02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920916
    NCBI Gene: 73666
Location & Maps
more
  • Sequence Map
    Chr13:54458837-54468849 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10013 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 28.69 cM, cytoband B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    THOC3, THO complex 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    THOC3, THO complex 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hTREX45, THO3
  • Links
    NCBI Gene ID: 84321
    neXtProt AC: NX_Q96J01

  • Chr Location
    5q35.2; chr5:175938810-175968537 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12505
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: THOC3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Genomic Mutations
    1 involving Thoc3
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027733 VEGA Gene Model | MGI Sequence Detail 10013 C57BL/6J ±  kb
transcript OTTMUST00000068626 VEGA | MGI Sequence Detail 2335 Not Applicable  
polypeptide OTTMUSP00000034740 VEGA | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    44 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016312 THO complex subunit 3
  • InterPro Domains
    IPR024977 Anaphase-promoting complex subunit 4, WD40 domain
    IPR020472 G-protein beta WD-40 repeat
    IPR013979 Translation initiation factor, beta propellor-like domain
    IPR001680 WD40 repeat
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 76
    cDNA 76

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145327
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:204143 Wang L, et al., The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming. Cell Stem Cell. 2013 Dec 5;13(6):676-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory