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Thoc3 Gene Detail
Summary
  • Symbol
    Thoc3
  • Name
    THO complex 3
  • Synonyms
    2410044K02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920916
    NCBI Gene: 73666
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:54458837-54468840 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 28.69 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920916
protein coding gene Chr13:54458837-54468849 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020568
protein coding gene Chr13:53859206-53869219 (-)
A/J MGP_AJ_G0020522
protein coding gene Chr13:51885570-51895574 (-)
AKR/J MGP_AKRJ_G0020500
protein coding gene Chr13:53408849-53418856 (-)
BALB/cJ MGP_BALBcJ_G0020518
protein coding gene Chr13:52109726-52120153 (-)
C3H/HeJ MGP_C3HHeJ_G0020317
protein coding gene Chr13:53232866-53242917 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020952
protein coding gene Chr13:55504848-55514853 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018534
protein coding gene Chr13:49878483-49888662 (-)
CAST/EiJ MGP_CASTEiJ_G0019831
protein coding gene Chr13:53302020-53312036 (-)
CBA/J MGP_CBAJ_G0020277
protein coding gene Chr13:57611545-57621544 (-)
DBA/2J MGP_DBA2J_G0020400
protein coding gene Chr13:51451878-51461882 (-)
FVB/NJ MGP_FVBNJ_G0020379
protein coding gene Chr13:50902262-50913063 (-)
LP/J MGP_LPJ_G0020476
protein coding gene Chr13:54129037-54139042 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020408
protein coding gene Chr13:57103152-57113169 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020995
protein coding gene Chr13:52997336-53007342 (-)
PWK/PhJ MGP_PWKPhJ_G0019587
protein coding gene Chr13:51429090-51439353 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019414
protein coding gene Chr13:51896647-51906585 (-)
WSB/EiJ MGP_WSBEiJ_G0019893
protein coding gene Chr13:53331909-53341914 (-)



Homology
more
  • Human Ortholog
    THOC3, THO complex 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    THOC3, THO complex 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hTREX45, THO3
  • Links
    NCBI Gene ID: 84321
    neXtProt AC: NX_Q96J01
    UniProt: Q96J01

  • Chr Location
    5q35.2; chr5:175959531-176034905 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12505
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: THOC3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 73666 NCBI Gene Model | MGI Sequence Detail 10004 C57BL/6J ±  kb
transcript NM_028597 RefSeq | MGI Sequence Detail 2326 C57BL/6  
polypeptide Q8VE80 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 77
    cDNA 77

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145327
References
more
  • Summaries
    All 29
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:204143 Wang L, et al., The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming. Cell Stem Cell. 2013 Dec 5;13(6):676-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory