Cabp4 MGI Mouse Gene Detail - MGI:1920910 - calcium binding protein 4

Symbol

Cabp4
Name

calcium binding protein 4
Synonyms

2410038D05Rik

Feature Type

protein coding gene
IDs

MGI:1920910
NCBI Gene: 73660
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:4135423-4144033 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.84 cM
Mapping Data

1 experiment

SNPs within 2kb

45 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920910	protein coding gene	Chr19:4135423-4144080 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024648	protein coding gene	Chr19:970535-977177 (-)
A/J	MGP_AJ_G0024614	protein coding gene	Chr19:937331-941130 (-)
AKR/J	MGP_AKRJ_G0024587	protein coding gene	Chr19:961613-966449 (-)
BALB/cJ	MGP_BALBcJ_G0024614	protein coding gene	Chr19:925513-930135 (-)
C3H/HeJ	MGP_C3HHeJ_G0024382	protein coding gene	Chr19:957262-961621 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025062	protein coding gene	Chr19:1010551-1017456 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022491	protein coding gene	Chr19:879489-883649 (-)
CAST/EiJ	MGP_CASTEiJ_G0023854	protein coding gene	Chr19:965416-971371 (-)
CBA/J	MGP_CBAJ_G0024353	protein coding gene	Chr19:1067331-1072537 (-)
DBA/2J	MGP_DBA2J_G0024481	protein coding gene	Chr19:896347-901022 (-)
FVB/NJ	MGP_FVBNJ_G0024448	protein coding gene	Chr19:906495-911291 (-)
LP/J	MGP_LPJ_G0024567	protein coding gene	Chr19:965240-969958 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024478	protein coding gene	Chr19:1016081-1020208 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025109	protein coding gene	Chr19:958148-962917 (-)
PWK/PhJ	MGP_PWKPhJ_G0023600	protein coding gene	Chr19:948423-953246 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023405	protein coding gene	Chr19:939150-943318 (-)
WSB/EiJ	MGP_WSBEiJ_G0023916	protein coding gene	Chr19:945322-951248 (-)

Human Ortholog

CABP4, calcium binding protein 4

Vertebrate Orthologs

10

Human Ortholog

CABP4, calcium binding protein 4
Orthology source: HomoloGene, HGNC
Synonyms

CRSD, CSNB2B
Links

HGNC:1386

NCBI Gene ID: 57010

neXtProt AC: NX_P57796

UniProt: P57796
Chr Location

11q13.2; chr11:67452406-67461774 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 16927
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CABP4
Gene Tree

Cabp4

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Gene trapped

1
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with disruptions in this gene display structural and electrophysiological abnormalities in the retina.

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All GO Annotations

15
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

687
Tissues

10
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cabp4

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Cabp4 interacts with 58 markers (Mir30c-1, Mir30c-2, Mir96, ...) View All

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS29416.1
UniGene

379226

Ensembl

ENSMUSG00000024842 (Evidence)
NCBI Gene

73660

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024842	Ensembl Gene Model \| MGI Sequence Detail	8611	C57BL/6J	± kb
transcript	ENSMUST00000025761	Ensembl \| MGI Sequence Detail	1433	Not Applicable
polypeptide	ENSMUSP00000025761	Ensembl \| MGI Sequence Detail	271	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004936 calcium-binding protein 4

(term hierarchy)
PDB

2M28, 2M29
InterPro Domains

IPR043582 Calcium binding protein 1/2/4/5

IPR033014 Calcium-binding protein 4

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

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All nucleic 17

cDNA 17

Microarray probesets 2

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 11
Earliest

J:59389 Haeseleer F, et al., Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem. 2000 Jan 14;275(2):1247-60
Latest

J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4)

TSS for Cabp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157457	Chr19:4139625-4139630 (-)	4,405 bp
Tssr157456	Chr19:4139605-4139613 (-)	4,424 bp
Tssr157455	Chr19:4139562-4139580 (-)	4,462 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/05/2021 MGI 6.16