Cabp4 MGI Mouse Gene Detail - MGI:1920910 - calcium binding protein 4

Cabp4 Gene Detail

Symbol

Cabp4
Name

calcium binding protein 4
Synonyms

2410038D05Rik

Feature Type

protein coding gene
IDs

MGI:1920910
NCBI Gene: 73660

Sequence Map

Chr19:4135425-4139609 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

4185 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.84 cM
Mapping Data

1 experiment

Human Ortholog

CABP4, calcium binding protein 4

Vertebrate Orthologs

10

Human Ortholog

CABP4, calcium binding protein 4
Orthology source: HomoloGene, HGNC
Synonyms

CRSD, CSNB2B
Links

HGNC:1386

NCBI Gene ID: 57010

neXtProt AC: NX_P57796
Chr Location

11q13.2; chr11:67452415-67461774 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 16927
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: CABP4
Gene Tree

Cabp4

Diseases

1 with human CABP4 associations

				Human Disease	Mouse Models
				Cone-Rod Synaptic Disorder, Congenital Nonprogressive; CRSD OMIM: 610427

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Gene trapped

1
Targeted

3
Incidental Mutations

APF

Mice with disruptions in this gene display structural and electrophysiological abnormalities in the retina.

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All GO Annotations

11
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

56
Tissues

10
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase cabp4

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Cabp4 interacts with 58 markers (Mir30c-1, Mir30c-2, Mir96, ...) View All

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All Sequences

16
RefSeq

4
UniProt

2
CCDS

CCDS29416.1
UniGene

379226

Ensembl

ENSMUSG00000024842 (Evidence)
NCBI Gene

73660 (Evidence)

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024842	Ensembl Gene Model \| MGI Sequence Detail	4185	C57BL/6J	± kb
transcript	ENSMUST00000025761	Ensembl \| MGI Sequence Detail	1431	Not Applicable
polypeptide	ENSMUSP00000025761	Ensembl \| MGI Sequence Detail	271	Not Applicable

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SNPs within 2kb

33 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000004936 calcium-binding protein 4
PDB

2M28, 2M29
InterPro Domains

IPR033014 Calcium-binding protein 4

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

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All nucleic 16

cDNA 16

Microarray probesets 2

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 8
Earliest

J:59389 Haeseleer F, et al., Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem. 2000 Jan 14;275(2):1247-60
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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