Ccrl2 MGI Mouse Gene Detail - MGI:1920904 - chemokine (C-C motif) receptor-like 2

Ccrl2 Gene Detail

Symbol

Ccrl2
Name

chemokine (C-C motif) receptor-like 2
Synonyms

1810047I05Rik, Ackr5, CCR11, Cmkbr1l2, L-CCR

Feature Type

protein coding gene
IDs

MGI:1920904
NCBI Gene: 54199
Gene Overview

MyGene.info: CCRL2

Sequence Map

Chr9:111054486-111057519 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

3034 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 60.92 cM, cytoband F
Mapping Data

2 experiments

Human Ortholog

CCRL2, C-C motif chemokine receptor like 2

Vertebrate Orthologs

7

Human Ortholog

CCRL2, C-C motif chemokine receptor like 2
Orthology source: HomoloGene, HGNC
Synonyms

ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR
Links

HGNC:1612

NCBI Gene ID: 9034

neXtProt AC: NX_O00421

UniProt: O00421
Chr Location

3p21.31; chr3:46407166-46409523 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2948
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: CCRL2
Protein SuperFamily

chemokine receptor
Gene Tree

Ccrl2

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available

Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls.

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All GO Annotations

18
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

102
Tissues

75
cDNA Data

22
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Ccrl2 interacts with 97 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

33
RefSeq

6
UniProt

2
CCDS

CCDS23582.1
UniGene

7336

			Length	Strain/Species	Flank
genomic	OTTMUSG00000052504	VEGA Gene Model \| MGI Sequence Detail	3034	C57BL/6J	± kb
transcript	OTTMUST00000131665	VEGA \| MGI Sequence Detail	2459	Not Applicable
polypeptide	OTTMUSP00000070351	VEGA \| MGI Sequence Detail	360	Not Applicable

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SNPs within 2kb

73 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000001214 C-C chemokine receptor-like 2

(term hierarchy)
InterPro Domains

IPR000355 Chemokine receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 7
Earliest

J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
Latest

J:223525 Banas M, et al., The expression and regulation of chemerin in the epidermis. PLoS One. 2015;10(2):e0117830

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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