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Ccrl2 Gene Detail
Summary
  • Symbol
    Ccrl2
  • Name
    chemokine (C-C motif) receptor-like 2
  • Synonyms
    1810047I05Rik, Ackr5, CCR11, Cmkbr1l2, L-CCR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920904
    NCBI Gene: 54199
  • Gene Overview
    MyGene.info: CCRL2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr9:111054486-111057519 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      3034 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 60.92 cM, cytoband F
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CCRL2, C-C motif chemokine receptor like 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCRL2, C-C motif chemokine receptor like 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR
  • Links
    NCBI Gene ID: 9034
    neXtProt AC: NX_O00421
    UniProt: O00421

  • Chr Location
    3p21.31; chr3:46407166-46409523 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    102
  • Tissues
    75
  • cDNA Data
    23
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000052504 VEGA Gene Model | MGI Sequence Detail 3034 C57BL/6J ±  kb
    transcript OTTMUST00000131665 VEGA | MGI Sequence Detail 2459 Not Applicable  
    polypeptide OTTMUSP00000070351 VEGA | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      73 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
    • Latest
      J:247010 Del Prete A, et al., The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage. Blood. 2017 Sep 07;130(10):1223-1234
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/18/2018
    MGI 6.12     		The Jackson Laboratory