Ccrl2
Gene Detail

Symbol Name ID

Ccrl2 chemokine (C-C motif) receptor-like 2 MGI:1920904

Synonyms

1810047I05Rik, Ackr5, CCR11, Cmkbr1l2, L-CCR

Feature Type

protein coding gene

Genetic Map

Chromosome 9

60.92 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:111054835-111057270 bp, - strand From NCBI annotation of GRCm38   2436 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2948  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: chemokine receptor
Gene Tree: Ccrl2

Human homologs

Human Homolog		CCRL2, chemokine (C-C motif) receptor-like 2
NCBI Gene ID		9034
neXtProt AC		NX_O00421
Human Synonyms		ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR
Human Chr (Location)		3p21; chr3:46407230-46409523 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls.

 

Interactions

Ccrl2 interacts with 97 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	chemokine-mediated signaling pathway, chemotaxis, ...
Component	integral component of membrane, integral component of plasma membrane, ...
Function	C-C chemokine receptor activity, CCR chemokine receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (102)    Tissues (75)    Images (16)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	67
RT-PCR	35

cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000043953 (Evidence)
Entrez Gene	54199 (Evidence)
UniGene	7336
DFCI	TC1583505
DoTS	DT.101346274, DT.40181988, DT.99688522
NIA Mouse Gene Index	U031376
Consensus CDS Project	CCDS23582.1
International Mouse Knockout Project Status	Ccrl2

Sequences

Length	Strain/Species
genomic	54199	NCBI Gene Model | MGI Sequence Detail	2436	C57BL/6J
transcript	NM_017466	RefSeq | MGI Sequence Detail	2110	C57BL/6
polypeptide	O35457	UniProt | EBI | MGI Sequence Detail	360	Not Applicable

All sequences(25) RefSeq(6) UniProt(1)

Polymorphisms

SNPs within 2kb(69 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000355	Chemokine receptor family
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001214	C-C chemokine receptor-like 2

Graphical View of Protein Domain Structure

References

(Earliest) J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(39)