Ccrl2 MGI Mouse Gene Detail - MGI:1920904 - chemokine (C-C motif) receptor-like 2

Symbol

Ccrl2
Name

chemokine (C-C motif) receptor-like 2
Synonyms

1810047I05Rik, Ackr5, CCR11, Cmkbr1l2, L-CCR

Feature Type

protein coding gene
IDs

MGI:1920904
NCBI Gene: 54199
Gene Overview

MyGene.info: CCRL2
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr9:111054834-111057518 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 60.92 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

72 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920904	protein coding gene	Chr9:111054486-111057519 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035369	protein coding gene	Chr9:113254984-113258015 (-)
A/J	MGP_AJ_G0035350	protein coding gene	Chr9:109123268-109126298 (-)
AKR/J	MGP_AKRJ_G0035281	protein coding gene	Chr9:111844941-111847971 (-)
BALB/cJ	MGP_BALBcJ_G0035345	protein coding gene	Chr9:108875880-108878910 (-)
C3H/HeJ	MGP_C3HHeJ_G0035053	protein coding gene	Chr9:112344670-112347700 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035867	protein coding gene	Chr9:116385006-116388039 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032753	protein coding gene	Chr9:106334539-106337607 (-)
CAST/EiJ	MGP_CASTEiJ_G0034359	protein coding gene	Chr9:112148987-112152019 (-)
CBA/J	MGP_CBAJ_G0035020	protein coding gene	Chr9:120666166-120669197 (-)
DBA/2J	MGP_DBA2J_G0035179	protein coding gene	Chr9:108577887-108580917 (-)
FVB/NJ	MGP_FVBNJ_G0035126	protein coding gene	Chr9:107423969-107426999 (-)
LP/J	MGP_LPJ_G0035258	protein coding gene	Chr9:113543375-113546406 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035166	protein coding gene	Chr9:121981978-121985008 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035887	protein coding gene	Chr9:112193871-112196904 (-)
PWK/PhJ	MGP_PWKPhJ_G0034066	protein coding gene	Chr9:108825350-108828382 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033901	protein coding gene	Chr9:112281614-112284646 (-)
WSB/EiJ	MGP_WSBEiJ_G0034480	protein coding gene	Chr9:112058047-112061080 (-)

Human Ortholog

CCRL2, C-C motif chemokine receptor like 2

Vertebrate Orthologs

7

Human Ortholog

CCRL2, C-C motif chemokine receptor like 2
Orthology source: HomoloGene, HGNC
Synonyms

ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR
Links

HGNC:1612

NCBI Gene ID: 9034

neXtProt AC: NX_O00421

UniProt: O00421
Chr Location

3p21.31; chr3:46407166-46409523 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2948
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: CCRL2
Protein SuperFamily

chemokine receptor
Gene Tree

Ccrl2

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls.

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All GO Annotations

38
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

102
Tissues

75
cDNA Data

23
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Ccrl2 interacts with 97 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

44
RefSeq

6
UniProt

2
CCDS

CCDS23582.1
UniGene

7336

Ensembl

ENSMUSG00000043953 (Evidence)
NCBI Gene

54199

			Length	Strain/Species	Flank
genomic	54199	NCBI Gene Model \| MGI Sequence Detail	2685	C57BL/6J	± kb
transcript	NM_017466	RefSeq \| MGI Sequence Detail	2121	C57BL/6
polypeptide	O35457	UniProt \| EBI \| MGI Sequence Detail	360	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001214 C-C chemokine receptor-like 2

(term hierarchy)
InterPro Domains

IPR000355 Chemokine receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 24

cDNA 23

Primer pair 1

Microarray probesets 3

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 8
Earliest

J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
Latest

J:247010 Del Prete A, et al., The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage. Blood. 2017 Sep 07;130(10):1223-1234

TSS for Ccrl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91709	Chr9:111057508-111057523 (-)	2 bp
Tssr91708	Chr9:111057489-111057506 (-)	20 bp
Tssr91707	Chr9:111057456-111057485 (-)	47 bp
Tssr91706	Chr9:111057422-111057435 (-)	89 bp
Tssr91705	Chr9:111057235-111057252 (-)	274 bp
Tssr91704	Chr9:111057190-111057233 (-)	306 bp
Tssr91703	Chr9:111056900-111056915 (-)	610 bp
Tssr91702	Chr9:111056840-111056893 (-)	651 bp
Tssr91701	Chr9:111056584-111056607 (-)	922 bp
Tssr91700	Chr9:111056484-111056499 (-)	1,026 bp
Tssr91699	Chr9:111056412-111056470 (-)	1,077 bp
Tssr91698	Chr9:111056367-111056397 (-)	1,136 bp
Tssr91697	Chr9:111056296-111056338 (-)	1,201 bp
Tssr91696	Chr9:111056266-111056287 (-)	1,241 bp
Tssr91695	Chr9:111056069-111056099 (-)	1,434 bp
Tssr91694	Chr9:111055986-111056018 (-)	1,516 bp
Tssr91693	Chr9:111055958-111055980 (-)	1,549 bp
Tssr91692	Chr9:111055936-111055956 (-)	1,572 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/06/2018 MGI 6.13