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Capn9 Gene Detail
Summary
  • Symbol
    Capn9
  • Name
    calpain 9
  • Synonyms
    GC36, nCL-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920897
    NCBI Gene: 73647
  • Gene Overview
    MyGene.info: CAPN9
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124576111-124618731 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 72.81 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    734 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920897
protein coding gene Chr8:124576062-124618731 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034273
protein coding gene Chr8:128266970-128312944 (+)
A/J MGP_AJ_G0034253
protein coding gene Chr8:122959640-123000734 (+)
AKR/J MGP_AKRJ_G0034180
protein coding gene Chr8:126496802-126538283 (+)
BALB/cJ MGP_BALBcJ_G0034246
protein coding gene Chr8:123145120-123186672 (+)
C3H/HeJ MGP_C3HHeJ_G0033957
protein coding gene Chr8:127144908-127183645 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034766
protein coding gene Chr8:132554870-132594571 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031707
protein coding gene Chr8:115728451-115767030 (+)
CAST/EiJ MGP_CASTEiJ_G0033284
protein coding gene Chr8:127260860-127305466 (+)
CBA/J MGP_CBAJ_G0033930
protein coding gene Chr8:137421266-137465751 (+)
DBA/2J MGP_DBA2J_G0034086
protein coding gene Chr8:122115971-122158448 (+)
FVB/NJ MGP_FVBNJ_G0034030
protein coding gene Chr8:121288094-121325887 (+)
LP/J MGP_LPJ_G0034175
protein coding gene Chr8:128421402-128472193 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034077
protein coding gene Chr8:139501473-139545396 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034785
protein coding gene Chr8:126729654-126768545 (+)
PWK/PhJ MGP_PWKPhJ_G0032986
protein coding gene Chr8:121879840-121919331 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032825
protein coding gene Chr8:125376887-125416513 (+)
WSB/EiJ MGP_WSBEiJ_G0033401
protein coding gene Chr8:127453440-127500169 (+)



Homology
more
  • Human Ortholog
    CAPN9, calpain 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CAPN9, calpain 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GC36, nCL-4
  • Links
    NCBI Gene ID: 10753
    neXtProt AC: NX_O14815
    UniProt: O14815

  • Chr Location
    1q42.2; chr1:230747289-230803356 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased sensitivity to ethanol-induced gastric mucosa injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031981 Ensembl Gene Model | MGI Sequence Detail 42621 C57BL/6J ±  kb
transcript ENSMUST00000093033 Ensembl | MGI Sequence Detail 2330 Not Applicable  
polypeptide ENSMUSP00000090717 Ensembl | MGI Sequence Detail 690 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:73503 Lee HJ, et al., Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. 1998 Feb;379(2):175-83
  • Latest
    J:237762 Hata S, et al., A Gastrointestinal Calpain Complex, G-calpain, Is a Heterodimer of CAPN8 and CAPN9 Calpain Isoforms, Which Play Catalytic and Regulatory Roles, Respectively. J Biol Chem. 2016 Dec 30;291(53):27313-27322

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory