Capn9
Gene Detail

Symbol Name ID

Capn9 calpain 9 MGI:1920897

Synonyms

GC36, nCL-4

Feature Type

protein coding gene

Genetic Map

Chromosome 8

72.81 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:124576111-124618731 bp, + strand From VEGA annotation of GRCm38   42621 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38208  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Capn9

Human homologs

Human Homolog		CAPN9, calpain 9
NCBI Gene ID		10753
neXtProt AC		NX_O14815
Human Synonyms		GC36, nCL-4
Human Chr (Location)		1q42.11-q42.3; chr1:230883130-230937749 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit increased sensitivity to ethanol-induced gastric mucosa injury.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	proteolysis
Component	cytoplasm, intracellular
Function	calcium-dependent cysteine-type endopeptidase activity, calcium ion binding, ...

External Resources: FuncBase

Expression

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000029745 (Evidence)
Ensembl Gene Model	ENSMUSG00000031981 (Evidence)
Entrez Gene	73647 (Evidence)
UniGene	6209
DFCI	TC1588407
DoTS	DT.485590
NIA Mouse Gene Index	U009957
EC	3.4.22.-
Consensus CDS Project	CCDS40514.1
International Mouse Knockout Project Status	Capn9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029745	VEGA Gene Model | MGI Sequence Detail	42621	C57BL/6J
transcript	OTTMUST00000073813	VEGA | MGI Sequence Detail	2330	Not Applicable
polypeptide	OTTMUSP00000038256	VEGA | MGI Sequence Detail	690	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(621 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000169	Cysteine peptidase, cysteine active site
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR001300	Peptidase C2, calpain, catalytic domain
InterPro	IPR022683	Peptidase C2, calpain, domain III
InterPro	IPR022684	Peptidase C2, calpain family
InterPro	IPR022682	Peptidase C2, calpain, large subunit, domain III
Protein Ontology	PR:000005021	calpain-9

References

(Earliest) J:73503 Lee HJ, et al., Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. 1998 Feb;379(2):175-83
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)