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Capn9
Gene Detail
Symbol

Name
ID
Capn9
calpain 9
MGI:1920897
Synonyms
GC36, nCL-4
Feature Type
protein coding gene
Genetic Map
Chromosome 8
72.81 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:124576111-124618731 bp, + strand
From VEGA annotation of GRCm38

  42621 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38208  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Capn9

Human
homologs
Human Homolog CAPN9, calpain 9
NCBI Gene ID 10753
neXtProt AC  NX_O14815
Human Synonyms  GC36, nCL-4
Human Chr (Location)  1q42.11-q42.3; chr1:230747343-230802003 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased sensitivity to ethanol-induced gastric mucosa injury.
 
Interactions
Capn9 interacts with 47 markers (Mir22, Mir34a, Mir98, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process digestion, proteolysis
Component cytoplasm, intracellular
Function calcium-dependent cysteine-type endopeptidase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029745 (Evidence)
Ensembl Gene ModelENSMUSG00000031981 (Evidence)
Entrez Gene73647 (Evidence)
UniGene6209
DFCITC1588407
DoTSDT.485590
NIA Mouse Gene IndexU009957
EC3.4.22.-
Consensus CDS ProjectCCDS40514.1
International Mouse Knockout Project StatusCapn9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029745 VEGA Gene Model | MGI Sequence Detail 42621 C57BL/6J ±  kb
transcript OTTMUST00000073813 VEGA | MGI Sequence Detail 2330 Not Applicable 
polypeptide OTTMUSP00000038256 VEGA | MGI Sequence Detail 690 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(818 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR001300 Peptidase C2, calpain, catalytic domain
InterPro IPR022683 Peptidase C2, calpain, domain III
InterPro IPR022684 Peptidase C2, calpain family
InterPro IPR022682 Peptidase C2, calpain, large subunit, domain III
Protein Ontology PR:000005021 calpain-9
References
(Earliest) J:73503 Lee HJ, et al., Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. 1998 Feb;379(2):175-83
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory