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Ddx46 Gene Detail
Summary
  • Symbol
    Ddx46
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
  • Synonyms
    2200005K02Rik, 8430438J23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920895
    NCBI Gene: 212880
  • Gene Overview
    MyGene.info: DDX46
Location & Maps
more
  • Sequence Map
    Chr13:55635027-55681256 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46230 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DDX46, DEAD-box helicase 46
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DDX46, DEAD-box helicase 46
    Orthology source: HomoloGene
  • Synonyms
    Prp5, PRPF5
  • Links
    NCBI Gene ID: 9879
    neXtProt AC: NX_Q7L014

  • Chr Location
    5q31.1; chr5:134758734-134831138 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5430
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DDX46
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Genomic Mutations
    1 involving Ddx46
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021500 Ensembl Gene Model | MGI Sequence Detail 46230 C57BL/6J ±  kb
transcript ENSMUST00000172272 Ensembl | MGI Sequence Detail 5676 Not Applicable  
polypeptide ENSMUSP00000133245 Ensembl | MGI Sequence Detail 1032 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    177 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000030255 ATP-dependent RNA helicase DDX46
  • EC
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918802, MGI:2145213, MGI:2145315
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory