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Ddx46 Gene Detail
Summary
  • Symbol
    Ddx46
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
  • Synonyms
    2200005K02Rik, 8430438J23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920895
    NCBI Gene: 212880
  • Gene Overview
    MyGene.info: DDX46
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55635027-55681256 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.06 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920895
protein coding gene Chr13:55634974-55681267 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020607
protein coding gene Chr13:55129585-55180287 (+)
A/J MGP_AJ_G0020561
protein coding gene Chr13:53095439-53141734 (+)
AKR/J MGP_AKRJ_G0020539
protein coding gene Chr13:54661622-54715174 (+)
BALB/cJ MGP_BALBcJ_G0020557
protein coding gene Chr13:53322256-53371058 (+)
C3H/HeJ MGP_C3HHeJ_G0020356
protein coding gene Chr13:54467718-54517987 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020991
protein coding gene Chr13:56789263-56837258 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018573
protein coding gene Chr13:51028382-51078941 (+)
CAST/EiJ MGP_CASTEiJ_G0019870
protein coding gene Chr13:54576368-54627098 (+)
CBA/J MGP_CBAJ_G0020316
protein coding gene Chr13:58974264-59033764 (+)
DBA/2J MGP_DBA2J_G0020439
protein coding gene Chr13:52641892-52689387 (+)
FVB/NJ MGP_FVBNJ_G0020418
protein coding gene Chr13:52113221-52159530 (+)
LP/J MGP_LPJ_G0020515
protein coding gene Chr13:55382863-55432376 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020447
protein coding gene Chr13:58430564-58480007 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021034
protein coding gene Chr13:54243305-54295472 (+)
PWK/PhJ MGP_PWKPhJ_G0019626
protein coding gene Chr13:52668172-52717486 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019453
protein coding gene Chr13:53159621-53207663 (+)
WSB/EiJ MGP_WSBEiJ_G0019932
protein coding gene Chr13:54604125-54657301 (+)



Homology
more
  • Human Ortholog
    DDX46, DEAD-box helicase 46
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DDX46, DEAD-box helicase 46
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Prp5, PRPF5
  • Links
    NCBI Gene ID: 9879
    neXtProt AC: NX_Q7L014
    UniProt: Q7L014

  • Chr Location
    5q31.1; chr5:134758734-134831138 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5430
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DDX46
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021500 Ensembl Gene Model | MGI Sequence Detail 46230 C57BL/6J ±  kb
transcript ENSMUST00000223736 Ensembl | MGI Sequence Detail 5612 Not Applicable  
polypeptide ENSMUSP00000153328 Ensembl | MGI Sequence Detail 1032 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • EC
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918802, MGI:2145213, MGI:2145315
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory