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Vgll3 Gene Detail
Summary
  • Symbol
    Vgll3
  • Name
    vestigial like family member 3
  • Synonyms
    1700110N18Rik, Vito-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920819
    NCBI Gene: 73569
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:65612143-65663254 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 37.34 cM, cytoband C1.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    504 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920819
protein coding gene Chr16:65612075-65663254 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022946
protein coding gene Chr16:65362840-65410599 (+)
A/J MGP_AJ_G0022914
protein coding gene Chr16:62540067-62589380 (+)
AKR/J MGP_AKRJ_G0022884
protein coding gene Chr16:64507405-64556535 (+)
BALB/cJ MGP_BALBcJ_G0022916
protein coding gene Chr16:62763075-62810191 (+)
C3H/HeJ MGP_C3HHeJ_G0022678
protein coding gene Chr16:64804039-64852379 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023364
protein coding gene Chr16:67293353-67340587 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020867
protein coding gene Chr16:61550718-61598444 (+)
CAST/EiJ MGP_CASTEiJ_G0022201
protein coding gene Chr16:65011588-65062709 (+)
CBA/J MGP_CBAJ_G0022649
protein coding gene Chr16:70179332-70229126 (+)
DBA/2J MGP_DBA2J_G0022781
protein coding gene Chr16:62297184-62353639 (+)
FVB/NJ MGP_FVBNJ_G0022755
protein coding gene Chr16:61909957-61958464 (+)
LP/J MGP_LPJ_G0022850
protein coding gene Chr16:65151038-65203263 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022774
protein coding gene Chr16:71402053-71453733 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023380
protein coding gene Chr16:64589276-64641879 (+)
PWK/PhJ MGP_PWKPhJ_G0021944
protein coding gene Chr16:62466559-62519092 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021773
protein coding gene Chr16:64292899-64342833 (+)
WSB/EiJ MGP_WSBEiJ_G0022248
protein coding gene Chr16:64675110-64729452 (+)



Homology
more
  • Human Ortholog
    VGLL3, vestigial like family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VGLL3, vestigial like family member 3
  • Synonyms
    VGL3, VGL-3
  • Links
    NCBI Gene ID: 389136
    neXtProt AC: NX_A8MV65
    UniProt: A8MV65

  • Chr Location
    3p12.1; chr3:86876388-86991149 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and overtly normal with no apparent defects in skeletal muscle development or myoblast function. Mice from another knock-out allele show attenuated myocardial infraction-induced cardiac fibrosis and cardiac function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000091243 Ensembl Gene Model | MGI Sequence Detail 51112 C57BL/6J ±  kb
    transcript ENSMUST00000168064 Ensembl | MGI Sequence Detail 7009 Not Applicable  
    polypeptide ENSMUSP00000131500 Ensembl | MGI Sequence Detail 325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146708
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:339852 Horii Y, et al., VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation. Nat Commun. 2023 Feb 8;14(1):550

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory