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Spata18 Gene Detail
Summary
  • Symbol
    Spata18
  • Name
    spermatogenesis associated 18
  • Synonyms
    1700067I02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920722
    NCBI Gene: 73472
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:73651365-73679484 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 39.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920722
protein coding gene Chr5:73651365-73679512 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029629
protein coding gene Chr5:73665531-73693663 (+)
A/J MGP_AJ_G0029597
protein coding gene Chr5:70901285-70930467 (+)
AKR/J MGP_AKRJ_G0029545
protein coding gene Chr5:73204886-73233070 (+)
BALB/cJ MGP_BALBcJ_G0029606
protein coding gene Chr5:71613707-71642349 (+)
C3H/HeJ MGP_C3HHeJ_G0029329
protein coding gene Chr5:73601615-73635962 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030060
protein coding gene Chr5:76700563-76728857 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027300
protein coding gene Chr5:66581754-66609884 (+)
CAST/EiJ MGP_CASTEiJ_G0028737
protein coding gene Chr5:72670432-72700694 (+)
CBA/J MGP_CBAJ_G0029298
protein coding gene Chr5:79211885-79240090 (+)
DBA/2J MGP_DBA2J_G0029443
protein coding gene Chr5:70984554-71012866 (+)
FVB/NJ MGP_FVBNJ_G0029404
protein coding gene Chr5:70126351-70154476 (+)
LP/J MGP_LPJ_G0029529
protein coding gene Chr5:74110444-74138556 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029431
protein coding gene Chr5:82484488-82513812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030093
protein coding gene Chr5:72739293-72767412 (+)
PWK/PhJ MGP_PWKPhJ_G0028460
protein coding gene Chr5:69952878-69984568 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028295
protein coding gene Chr5:72093108-72121711 (+)
WSB/EiJ MGP_WSBEiJ_G0028817
protein coding gene Chr5:73041881-73070941 (+)



Homology
more
  • Human Ortholog
    SPATA18, spermatogenesis associated 18
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SPATA18, spermatogenesis associated 18
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Mieap, SPETEX1
  • Links
    NCBI Gene ID: 132671
    neXtProt AC: NX_Q8TC71
    UniProt: Q8TC71

  • Chr Location
    4q12; chr4:52051331-52097305 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from multigenic genotypes
    265 phenotype references
Homo- or heterozygous KO in mice also carrying one copy of the ApcMin allele leads to increased intestinal adenoma and adenocarcinoma tumor incidence and size. This double mutation and homozygous KO of the gene alone results in lower internal mitochondrial cristae density in small intestinal mucosal epithelium.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 73472 NCBI Gene Model | MGI Sequence Detail 28120 C57BL/6J ±  kb
transcript NM_178387 RefSeq | MGI Sequence Detail 1949 C57BL/6  
polypeptide Q0P557 UniProt | EBI | MGI Sequence Detail 537 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 289
    Diseases 1
    Gene Ontology 5
    Phenotypes 265
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:268167 Melo H, et al., Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation. Sci Rep. 2018 Oct 19;8(1):15551

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory