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Prox2 Gene Detail
Summary
  • Symbol
    Prox2
  • Name
    prospero homeobox 2
  • Synonyms
    1700058C01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920672
    NCBI Gene: 73422
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:85086385-85110759 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920672
protein coding gene Chr12:85085810-85110885 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019951
protein coding gene Chr12:85842640-85862681 (-)
A/J MGP_AJ_G0019908
protein coding gene Chr12:82589727-82609782 (-)
AKR/J MGP_AKRJ_G0019884
protein coding gene Chr12:84814321-84834368 (-)
BALB/cJ MGP_BALBcJ_G0019888
protein coding gene Chr12:82923245-82943301 (-)
C3H/HeJ MGP_C3HHeJ_G0019694
protein coding gene Chr12:85294659-85314704 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020339
protein coding gene Chr12:88313014-88336566 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017957
protein coding gene Chr12:79474395-79495234 (-)
CAST/EiJ MGP_CASTEiJ_G0019243
protein coding gene Chr12:80263941-80287009 (-)
CBA/J MGP_CBAJ_G0019665
protein coding gene Chr12:91711534-91731985 (-)
DBA/2J MGP_DBA2J_G0019780
protein coding gene Chr12:82105313-82125702 (-)
FVB/NJ MGP_FVBNJ_G0019766
protein coding gene Chr12:81066161-81086217 (-)
LP/J MGP_LPJ_G0019852
protein coding gene Chr12:85718685-85740027 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019805
protein coding gene Chr12:94586994-94606988 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020373
protein coding gene Chr12:84424835-84444880 (-)
PWK/PhJ MGP_PWKPhJ_G0019007
protein coding gene Chr12:76596500-76616683 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018802
protein coding gene Chr12:78905857-78926070 (-)
WSB/EiJ MGP_WSBEiJ_G0019295
protein coding gene Chr12:85146073-85166135 (-)



Homology
more
  • Human Ortholog
    PROX2, prospero homeobox 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PROX2, prospero homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PROX-2
  • Links
    NCBI Gene ID: 283571
    neXtProt AC: NX_Q3B8N5
    UniProt: Q3B8N5

  • Chr Location
    14q24.3; chr14:74853033-74876663 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal growth, survival and fertility, with no detectable defects in eye structure or horizontal cell development in the retina.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042320 Ensembl Gene Model | MGI Sequence Detail 24375 C57BL/6J ±  kb
    transcript ENSMUST00000177289 Ensembl | MGI Sequence Detail 3066 Not Applicable  
    polypeptide ENSMUSP00000135881 Ensembl | MGI Sequence Detail 593 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 10
      Primer pair 4
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 8
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:238230 Furlan A, et al., Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Nat Neurosci. 2016 Oct;19(10):1331-40

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory