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Nme8 Gene Detail
Summary
  • Symbol
    Nme8
  • Name
    NME/NM23 family member 8
  • Synonyms
    1700056P15Rik, Sptrx-2, Txndc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920662
    NCBI Gene: 73412
Location & Maps
more
  • Sequence Map
    Chr13:19645078-19697794 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52717 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NME8, NME/NM23 family member 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NME8, NME/NM23 family member 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CILD6, HEL-S-99, NM23-H8, sptrx-2, SPTRX2, TXNDC3
  • Links
    NCBI Gene ID: 51314
    neXtProt AC: NX_Q8N427

  • Chr Location
    7p14.1; chr7:37848597-37900401 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NME8 associations

Human Disease Mouse Models
       Ciliary Dyskinesia, Primary, 6; CILD6   OMIM: 610852
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    9 phenotype references
  • All Mutations and Alleles
    3
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Nme8
  • Incidental Mutations
Homozygous mutant displays normal reproductive system phenotype
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024181 VEGA Gene Model | MGI Sequence Detail 52717 C57BL/6J ±  kb
transcript OTTMUST00000059158 VEGA | MGI Sequence Detail 2122 Not Applicable  
polypeptide OTTMUSP00000028749 VEGA | MGI Sequence Detail 586 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    449 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016861 thioredoxin domain-containing protein 3
  • InterPro Domains
    IPR001564 Nucleoside diphosphate kinase
    IPR017937 Thioredoxin, conserved site
    IPR013766 Thioredoxin domain
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
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  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:205172 Smith TB, et al., Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Free Radic Biol Med. 2013 Dec;65:872-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory