Nme8
Gene Detail

Symbol Name ID

Nme8 NME/NM23 family member 8 MGI:1920662

Synonyms

1700056P15Rik, Sptrx-2, Txndc3

Feature Type

protein coding gene

Genetic Map

Chromosome 13

7.00 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:19645078-19697794 bp, - strand From VEGA annotation of GRCm38   52717 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9593  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: outer arm dynein intermediate chain with thioredoxin and NDK domains
Gene Tree: Nme8

Human homologs

Human Homolog		NME8, NME/NM23 family member 8
NCBI Gene ID		51314
neXtProt AC		NX_Q8N427
Human Synonyms		CILD6, NM23-H8, sptrx-2, SPTRX2, TXNDC3
Human Chr (Location)		7p14.1; chr7:37888199-37940003 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NME8

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cell differentiation, cell redox homeostasis, ...
Component	cytoplasm, microtubule cytoskeleton
Function	ATP binding, nucleoside diphosphate kinase activity

External Resources: FuncBase

Expression

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) cDNA(5)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000024181 (Evidence)
Ensembl Gene Model	ENSMUSG00000041138 (Evidence)
Entrez Gene	73412 (Evidence)
UniGene	279939
DFCI	TC1589165
DoTS	DT.101361035, DT.55138037
NIA Mouse Gene Index	U034546
Consensus CDS Project	CCDS26262.2, CCDS49208.1
International Mouse Knockout Project Status	Nme8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024181	VEGA Gene Model | MGI Sequence Detail	52717	C57BL/6J
transcript	OTTMUST00000059158	VEGA | MGI Sequence Detail	2122	Not Applicable
polypeptide	OTTMUSP00000028749	VEGA | MGI Sequence Detail	586	Not Applicable

All sequences(25) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(252 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001564	Nucleoside diphosphate kinase
InterPro	IPR017937	Thioredoxin, conserved site
InterPro	IPR013766	Thioredoxin domain
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000016861	thioredoxin domain-containing protein 3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(26)