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Nme8 Gene Detail
Summary
  • Symbol
    Nme8
  • Name
    NME/NM23 family member 8
  • Synonyms
    1700056P15Rik, Sptrx-2, Txndc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920662
    NCBI Gene: 73412
  • Gene Overview
    MyGene.info: NME8
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:19645078-19697794 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 7.00 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920662
protein coding gene Chr13:19645061-19697827 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020261
protein coding gene Chr13:16821479-16880913 (-)
A/J MGP_AJ_G0020218
protein coding gene Chr13:16551897-16603712 (-)
AKR/J MGP_AKRJ_G0020192
protein coding gene Chr13:16750383-16811971 (-)
BALB/cJ MGP_BALBcJ_G0020204
protein coding gene Chr13:16580578-16635936 (-)
C3H/HeJ MGP_C3HHeJ_G0020007
protein coding gene Chr13:16882002-16934769 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020648
protein coding gene Chr13:17475325-17527447 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018255
protein coding gene Chr13:14983801-15042359 (-)
CAST/EiJ MGP_CASTEiJ_G0019542
protein coding gene Chr13:16614650-16672267 (-)
CBA/J MGP_CBAJ_G0019971
protein coding gene Chr13:18076625-18137618 (-)
DBA/2J MGP_DBA2J_G0020090
protein coding gene Chr13:16145766-16198125 (-)
FVB/NJ MGP_FVBNJ_G0020072
protein coding gene Chr13:15828522-15884110 (-)
LP/J MGP_LPJ_G0020161
protein coding gene Chr13:17066803-17122294 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020110
protein coding gene Chr13:18506054-18581690 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020677
protein coding gene Chr13:16571664-16633673 (-)
PWK/PhJ MGP_PWKPhJ_G0019305
protein coding gene Chr13:16199842-16253209 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019111
protein coding gene Chr13:15647827-15696777 (-)
WSB/EiJ MGP_WSBEiJ_G0019601
protein coding gene Chr13:16630688-16685510 (-)



Homology
more
  • Human Ortholog
    NME8, NME/NM23 family member 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NME8, NME/NM23 family member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD6, HEL-S-99, NM23-H8, sptrx-2, SPTRX2, TXNDC3
  • Links
    NCBI Gene ID: 51314
    neXtProt AC: NX_Q8N427
    UniProt: Q8N427

  • Chr Location
    7p14.1; chr7:37848597-37900401 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NME8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    9 phenotype references
Homozygous mutant displays normal reproductive system phenotype
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041138 Ensembl Gene Model | MGI Sequence Detail 52717 C57BL/6J ±  kb
transcript ENSMUST00000091763 Ensembl | MGI Sequence Detail 2122 Not Applicable  
polypeptide ENSMUSP00000089358 Ensembl | MGI Sequence Detail 586 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:205172 Smith TB, et al., Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Free Radic Biol Med. 2013 Dec;65:872-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory