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Nme8
Gene Detail
Symbol

Name
ID
Nme8
NME/NM23 family member 8
MGI:1920662
Synonyms
1700056P15Rik, Sptrx-2, Txndc3
Feature Type
protein coding gene
Genetic Map
Chromosome 13
7.00 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:19645078-19697794 bp, - strand
From VEGA annotation of GRCm38

  52717 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9593  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: outer arm dynein intermediate chain with thioredoxin and NDK domains
Gene Tree: Nme8

Human
homologs
Human Homolog NME8, NME/NM23 family member 8
NCBI Gene ID 51314
neXtProt AC  NX_Q8N427
Human Synonyms  CILD6, NM23-H8, sptrx-2, SPTRX2, TXNDC3
Human Chr (Location)  7p14.1; chr7:37848597-37900401 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NME8
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant displays normal reproductive system phenotype
 
Interactions
Nme8 interacts with 84 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell differentiation, cell redox homeostasis, ...
Component cytoplasm
Function ATP binding, nucleoside diphosphate kinase activity
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000024181 (Evidence)
Ensembl Gene ModelENSMUSG00000041138 (Evidence)
Entrez Gene73412 (Evidence)
UniGene279939
DFCITC1589165
DoTSDT.55138037, DT.101361035
NIA Mouse Gene IndexU034546
Consensus CDS ProjectCCDS26262.2, CCDS49208.1
International Mouse Knockout Project StatusNme8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024181 VEGA Gene Model | MGI Sequence Detail 52717 C57BL/6J ±  kb
transcript OTTMUST00000059158 VEGA | MGI Sequence Detail 2122 Not Applicable 
polypeptide OTTMUSP00000028749 VEGA | MGI Sequence Detail 586 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(449 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001564 Nucleoside diphosphate kinase
InterPro IPR017937 Thioredoxin, conserved site
InterPro IPR013766 Thioredoxin domain
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000016861 thioredoxin domain-containing protein 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205172 Smith TB, et al., Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Free Radic Biol Med. 2013 Dec;65:872-81
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory