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Timm21 Gene Detail
Summary
  • Symbol
    Timm21
  • Name
    translocase of inner mitochondrial membrane 21
  • Synonyms
    1700034H14Rik, 2700002I20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920595
    NCBI Gene: 67105
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:84946191-84951524 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 57.53 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920595
 protein coding gene Chr18:84946191-84951530 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024612
 protein coding gene Chr18:86118036-86122256 (-)
A/J MGP_AJ_G0024579
 protein coding gene Chr18:82345478-82349708 (-)
AKR/J MGP_AKRJ_G0024550
 protein coding gene Chr18:84795340-84799570 (-)
BALB/cJ MGP_BALBcJ_G0024577
 protein coding gene Chr18:82537028-82541258 (-)
C3H/HeJ MGP_C3HHeJ_G0024346
 protein coding gene Chr18:84900985-84905215 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025024
 protein coding gene Chr18:88273079-88277309 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022454
 protein coding gene Chr18:81031828-81036227 (-)
CAST/EiJ MGP_CASTEiJ_G0023819
 protein coding gene Chr18:85297216-85302230 (-)
CBA/J MGP_CBAJ_G0024316
 protein coding gene Chr18:91459384-91463520 (-)
DBA/2J MGP_DBA2J_G0024445
 protein coding gene Chr18:81862992-81867222 (-)
FVB/NJ MGP_FVBNJ_G0024412
 protein coding gene Chr18:81199460-81203690 (-)
LP/J MGP_LPJ_G0024530
 protein coding gene Chr18:85925665-85930032 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024442
 protein coding gene Chr18:92712942-92717175 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025073
 protein coding gene Chr18:85022369-85026605 (-)
PWK/PhJ MGP_PWKPhJ_G0023564
 protein coding gene Chr18:82280294-82284654 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023370
 protein coding gene Chr18:85036949-85041236 (-)
WSB/EiJ MGP_WSBEiJ_G0023881
 protein coding gene Chr18:84967531-84973236 (-)



Homology
more
  • Human Ortholog
    TIMM21, translocase of inner mitochondrial membrane 21
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TIMM21, translocase of inner mitochondrial membrane 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C18orf55, HSPC154, TIM21
  • Links
    NCBI Gene ID: 29090
    neXtProt AC: NX_Q9BVV7
    UniProt: Q9BVV7

  • Chr Location
    18q22.3; chr18:74148511-74158969 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 32211
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TIMM21
  • Gene Tree
    Timm21
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    4
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Timm21
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    18 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • cDNA Data
    79
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024645 Ensembl Gene Model | MGI Sequence Detail 5334 C57BL/6J ±  kb
transcript ENSMUST00000025547 Ensembl | MGI Sequence Detail 2418 Not Applicable  
polypeptide ENSMUSP00000025547 Ensembl | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000030615 mitochondrial import inner membrane translocase subunit Tim21
    (term hierarchy)
  • InterPro Domains
    IPR013261 Mitochondrial import inner membrane translocase subunit Tim21
    IPR038552 Tim21 IMS domain superfamily
Molecular
Reagents
less
  • All nucleic 79
    cDNA 79

    Microarray probesets 3
Other
Accession IDs
less
MGI:1914355
References
more
  • Summaries
    All 30
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/26/2020
MGI 6.15 		The Jackson Laboratory