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Arhgef6
Gene Detail
 Symbol
Name
ID
Arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
MGI:1920591
Synonyms 1600028C08Rik, 1700038J06Rik, 4930592P22Rik, alpha-PIX
Feature Type protein coding gene
Genetic Map
Chromosome X
31.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:57231485-57338729 bp, - strand
From VEGA annotation of GRCm38

  107245 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3561  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Arhgef6

Human
homologs
Human Homolog ARHGEF6, Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
NCBI Gene ID 9459
neXtProt AC  NX_Q15052
Human Synonyms  alphaPIX, alpha-PIX, Cool-2, COOL2, MRX46, PIXA
Human Chr (Location)  Xq26.3; chrX:136665549-136781344 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ARHGEF6
Alleles
and
phenotypes
All alleles(7) : Gene trapped(1) Targeted(6)
 
Mice homozygous for a truncated allele exhibit decreased mature lymphocyte cell numbers, decreased B and T cell proliferation, and defective humeral response. Mice homozygous for a reporter allele exhibit abnormal dendrite morphology and synaptic plasticity and cognitive defects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process intracellular signal transduction, lamellipodium assembly, ...
Component cell-cell junction, cell projection, ...
Function guanyl-nucleotide exchange factor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (5)   
Theiler Stages: 21, 25, 28
Assay TypeResults
Northern blot 6
cDNA source data(52)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(53) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017820 (Evidence)
Ensembl Gene ModelENSMUSG00000031133 (Evidence)
Entrez Gene73341 (Evidence)
UniGene261443
DFCITC1580901, TC1599616, TC1617839
DoTSDT.101367499, DT.111033308, DT.40141643, DT.485138, DT.87030192
NIA Mouse Gene IndexU039394
PDB1V61
Consensus CDS ProjectCCDS40984.2
International Mouse Knockout Project StatusArhgef6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017820 VEGA Gene Model | MGI Sequence Detail 107245 C57BL/6J ±  kb
transcript OTTMUST00000043148 VEGA | MGI Sequence Detail 4569 Not Applicable 
polypeptide OTTMUSP00000019411 VEGA | MGI Sequence Detail 795 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(12) UniProt(5)
Polymorphisms SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001715 Calponin homology domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR003096 Smooth muscle protein/calponin
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000004259 rho guanine nucleotide exchange factor 6
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209876 Korthals M, et al., alphaPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes. J Immunol. 2014 Apr 1;192(7):3228-38
All references(39)
Other
accession IDs
MGI:1923183, MGI:1923947

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory