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Arhgef6
Gene Detail
Symbol

Name
ID
Arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
MGI:1920591
Synonyms
1600028C08Rik, 1700038J06Rik, 4930592P22Rik, alpha-PIX
Feature Type
protein coding gene
Genetic Map
Chromosome X
31.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:57231485-57338729 bp, - strand
From VEGA annotation of GRCm38

  107245 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3561  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARHGEF6
Gene Tree: Arhgef6

Human
homologs
ARHGEF6, Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9459
neXtProt AC: NX_Q15052

Human Synonyms: alphaPIX, alpha-PIX, Cool-2, COOL2, MRX46, PIXA

Human Chr (Location): Xq26.3; chrX:136665547-136781656 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ARHGEF6

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from CvDC )
 
Mice homozygous for a truncated allele exhibit decreased mature lymphocyte cell numbers, decreased B and T cell proliferation, and defective humeral response. Mice homozygous for a reporter allele exhibit abnormal dendrite morphology and synaptic plasticity and cognitive defects.
 
Interactions
Arhgef6 interacts with 341 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process intracellular signal transduction, lamellipodium assembly, ...
Component cell-cell junction, cell projection, ...
Function guanyl-nucleotide exchange factor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 6
cDNA source data(52)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA ARHGEF6 ; Xenbase arhgef6 ; ZFIN arhgef6    NEW 
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(53) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017820 (Evidence)
Ensembl Gene Model ENSMUSG00000031133 (Evidence)
Entrez Gene 73341 (Evidence)
UniGene 261443
DFCI TC1580901, TC1617839, TC1599616
DoTS DT.87030192, DT.485138, DT.101367499, DT.40141643, DT.111033308
NIA Mouse Gene Index U039394
PDB 1V61
Consensus CDS Project CCDS40984.2
International Mouse Phenotyping Consortium Status Arhgef6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017820 VEGA Gene Model | MGI Sequence Detail 107245 C57BL/6J ±  kb
transcript OTTMUST00000043148 VEGA | MGI Sequence Detail 4569 Not Applicable 
polypeptide OTTMUSP00000019411 VEGA | MGI Sequence Detail 795 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001715 Calponin homology domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR003096 Smooth muscle protein/calponin
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000004259 rho guanine nucleotide exchange factor 6
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209876 Korthals M, et al., alphaPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes. J Immunol. 2014 Apr 1;192(7):3228-38
All references(37)
Other
accession IDs
MGI:1923183, MGI:1923947

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory