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Nptxr
Gene Detail
Symbol

Name
ID
Nptxr
neuronal pentraxin receptor
MGI:1920590
Synonyms
1200009K17Rik, 1700036C17Rik, 5730406O18Rik, D15Bwg0580e, NPCD, NPR
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.85 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:79786353-79804766 bp, - strand
From VEGA annotation of GRCm38

  18414 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 2 zebrafish

HCOP human homology predictions: NPTXR
Gene Tree: Nptxr

Human
homologs
NPTXR, neuronal pentraxin receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23467
neXtProt AC: NX_O95502

Human Synonyms: NPR

Human Chr (Location): 22q13.1; chr22:38818451-38844012 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Nptxr (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation of this gene display a mild alteration in retinal ganglion cell innervation but are fertile with no obvious behavioral abnormalities.
 
Phenotype Images(2)
Interactions
Nptxr interacts with 270 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process neuron projection development, signal transduction
Component extracellular space, integral component of membrane, ...
Function metal ion binding, pentraxin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (25)    Tissues (16)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
cDNA source data(13)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase nptxr    NEW 
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(13) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034820 (Evidence)
Ensembl Gene Model ENSMUSG00000022421 (Evidence)
Entrez Gene 73340 (Evidence)
Consensus CDS Project CCDS27653.1
International Mouse Phenotyping Consortium Status Nptxr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034820 VEGA Gene Model | MGI Sequence Detail 18414 C57BL/6J ±  kb
transcript OTTMUST00000042348 VEGA | MGI Sequence Detail 5004 Not Applicable 
polypeptide OTTMUSP00000019030 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(8)
Polymorphisms
SNPs within 2kb(153 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase domain
InterPro IPR030476 Pentaxin, conserved site
InterPro IPR001759 Pentaxin-related
Protein Ontology PR:000011384 neuronal pentraxin receptor
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:221124 Pelkey KA, et al., Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons. Neuron. 2015 Mar 18;85(6):1257-72
All references(36)
Other
accession IDs
MGD-MRK-34009, MGI:106317, MGI:1921368, MGI:1921988, MGI:2146019, MGI:2146057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory