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Nptxr Gene Detail
Summary
  • Symbol
    Nptxr
  • Name
    neuronal pentraxin receptor
  • Synonyms
    1200009K17Rik, 1700036C17Rik, 5730406O18Rik, D15Bwg0580e, NPCD, NPR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920590
    NCBI Gene: 73340
  • Gene Overview
    MyGene.info: NPTXR
Location & Maps
more
  • Sequence Map
    Chr15:79786353-79804766 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18414 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.85 cM, cytoband E2
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    NPTXR, neuronal pentraxin receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NPTXR, neuronal pentraxin receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NPR
  • Links
    NCBI Gene ID: 23467
    neXtProt AC: NX_O95502

  • Chr Location
    22q13.1; chr22:38818451-38844012 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Nptxr
  • Incidental Mutations
Mice homozygous for a null mutation of this gene display a mild alteration in retinal ganglion cell innervation but are fertile with no obvious behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034820 VEGA Gene Model | MGI Sequence Detail 18414 C57BL/6J ±  kb
transcript OTTMUST00000042348 VEGA | MGI Sequence Detail 5004 Not Applicable  
polypeptide OTTMUSP00000019030 VEGA | MGI Sequence Detail 493 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    152 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000011384 neuronal pentraxin receptor
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain
    IPR030476 Pentaxin, conserved site
    IPR001759 Pentaxin-related
Molecular
Reagents
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  • All nucleic 15
    Genomic 1
    cDNA 13
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-34009, MGI:106317, MGI:1921368, MGI:1921988, MGI:2146019, MGI:2146057
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 3
    Phenotypes 22
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:221124 Pelkey KA, et al., Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons. Neuron. 2015 Mar 18;85(6):1257-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory