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Nptxr Gene Detail
Summary
  • Symbol
    Nptxr
  • Name
    neuronal pentraxin receptor
  • Synonyms
    1200009K17Rik, 1700036C17Rik, 5730406O18Rik, D15Bwg0580e, NPCD, NPR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920590
    NCBI Gene: 73340
  • Gene Overview
    MyGene.info: NPTXR
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79786351-79804709 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.85 cM, cytoband E2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920590
protein coding gene Chr15:79786351-79804766 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022086
protein coding gene Chr15:80083588-80101961 (-)
A/J MGP_AJ_G0022047
protein coding gene Chr15:77310211-77328585 (-)
AKR/J MGP_AKRJ_G0022022
protein coding gene Chr15:79471379-79489753 (-)
BALB/cJ MGP_BALBcJ_G0022053
protein coding gene Chr15:77323918-77342292 (-)
C3H/HeJ MGP_C3HHeJ_G0021824
protein coding gene Chr15:79461017-79479391 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022496
protein coding gene Chr15:83233333-83251753 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020026
protein coding gene Chr15:73795326-73813756 (-)
CAST/EiJ MGP_CASTEiJ_G0021345
protein coding gene Chr15:80179313-80197693 (-)
CBA/J MGP_CBAJ_G0021789
protein coding gene Chr15:85831174-85849546 (-)
DBA/2J MGP_DBA2J_G0021918
protein coding gene Chr15:76798477-76816847 (-)
FVB/NJ MGP_FVBNJ_G0021896
protein coding gene Chr15:75825085-75843447 (-)
LP/J MGP_LPJ_G0021986
protein coding gene Chr15:80271518-80289903 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021916
protein coding gene Chr15:90923610-90941997 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022510
protein coding gene Chr15:79500220-79520684 (-)
PWK/PhJ MGP_PWKPhJ_G0021087
protein coding gene Chr15:76809698-76828122 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020924
protein coding gene Chr15:79299142-79317473 (-)
WSB/EiJ MGP_WSBEiJ_G0021397
protein coding gene Chr15:79885766-79905153 (-)



Homology
more
  • Human Ortholog
    NPTXR, neuronal pentraxin receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NPTXR, neuronal pentraxin receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NPR
  • Links
    NCBI Gene ID: 23467
    neXtProt AC: NX_O95502
    UniProt: O95502

  • Chr Location
    22q13.1; chr22:38818451-38844012 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation of this gene display a mild alteration in retinal ganglion cell innervation but are fertile with no obvious behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 73340 NCBI Gene Model | MGI Sequence Detail 18359 C57BL/6J ±  kb
transcript NM_030689 RefSeq | MGI Sequence Detail 4973 C57BL/6  
polypeptide Q99J85 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    IPR030476 Pentaxin, conserved site
    IPR001759 Pentraxin-related
Molecular
Reagents
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  • All nucleic 15
    Genomic 1
    cDNA 13
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-34009, MGI:106317, MGI:1921368, MGI:1921988, MGI:2146019, MGI:2146057
References
more
  • Summaries
    All 57
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 7
    Phenotypes 23
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:263375 Lee SJ, et al., Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses. J Neurosci. 2017 Feb 1;37(5):1062-1080

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory