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Pradc1 Gene Detail
Summary
  • Symbol
    Pradc1
  • Name
    protease-associated domain containing 1
  • Synonyms
    1700040I03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920577
    NCBI Gene: 73327
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85446810-85451970 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.46 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920577
protein coding gene Chr6:85446785-85451970 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030954
protein coding gene Chr6:86613423-86618569 (-)
A/J MGP_AJ_G0030923
protein coding gene Chr6:83315501-83320753 (-)
AKR/J MGP_AKRJ_G0030851
protein coding gene Chr6:85728814-85733954 (-)
BALB/cJ MGP_BALBcJ_G0030933
protein coding gene Chr6:83308106-83313245 (-)
C3H/HeJ MGP_C3HHeJ_G0030777
protein coding gene Chr6:98711762-98717724 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031393
protein coding gene Chr6:88997897-89003039 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028578
protein coding gene Chr6:81589443-81594163 (-)
CAST/EiJ MGP_CASTEiJ_G0030042
protein coding gene Chr6:85743823-85748733 (-)
CBA/J MGP_CBAJ_G0030620
protein coding gene Chr6:92487006-92492143 (-)
DBA/2J MGP_DBA2J_G0030773
protein coding gene Chr6:82598673-82603810 (-)
FVB/NJ MGP_FVBNJ_G0030726
protein coding gene Chr6:81800810-81805950 (-)
LP/J MGP_LPJ_G0030852
protein coding gene Chr6:86609204-86614343 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030762
protein coding gene Chr6:96691676-96696816 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031417
protein coding gene Chr6:85529518-85534663 (-)
PWK/PhJ MGP_PWKPhJ_G0029757
protein coding gene Chr6:81533916-81539050 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029585
protein coding gene Chr6:84387615-84392763 (-)
WSB/EiJ MGP_WSBEiJ_G0030123
protein coding gene Chr6:85976651-85983436 (-)



Homology
more
  • Human Ortholog
    PRADC1, protease associated domain containing 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRADC1, protease associated domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C2orf7, PAP21
  • Links
    NCBI Gene ID: 84279
    neXtProt AC: NX_Q9BSG0
    UniProt: Q9BSG0

  • Chr Location
    2p13.2; chr2:73228006-73233228 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation results in increased mean serum glucose levels in both males and females when compared with controls.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030008 Ensembl Gene Model | MGI Sequence Detail 5161 C57BL/6J ±  kb
    transcript ENSMUST00000032080 Ensembl | MGI Sequence Detail 1038 Not Applicable  
    polypeptide ENSMUSP00000032080 Ensembl | MGI Sequence Detail 188 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 43

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory