Calr3
Gene Detail

Symbol Name ID

Calr3 calreticulin 3 MGI:1920566

Synonyms

1700031L01Rik, 6330586I20Rik, Crt2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

35.08 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:72424176-72443870 bp, - strand From VEGA annotation of GRCm38   19695 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:57091  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: calreticulin
Gene Tree: Calr3

Human homologs

Human Homolog		CALR3, calreticulin 3
NCBI Gene ID		125972
neXtProt AC		NX_Q96L12
Human Synonyms		CMH19, CRT2, CT93
Human Chr (Location)		19p13.11; chr19:16589868-16607003 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CALR3

Alleles and phenotypes

All alleles(12) : Targeted(2) Gene trapped(10)
 

Mice homozygous for a knock-out allele exhibit male infertility associated with impaired zona pellucida binding and fertilization.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	cell differentiation, protein folding, ...
Component	endoplasmic reticulum
Function	calcium ion binding, unfolded protein binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (4)    Images (3)
Theiler Stages: 21, 25, 28

Assay Type	Results
RNA in situ	4

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(9) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031770 (Evidence)
Ensembl Gene Model	ENSMUSG00000019732 (Evidence)
Entrez Gene	73316 (Evidence)
UniGene	196315
DFCI	TC1585828, TC1593332
DoTS	DT.526837, DT.91328537
NIA Mouse Gene Index	U029963
Consensus CDS Project	CCDS22413.1, CCDS40388.1
International Mouse Knockout Project Status	Calr3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031770	VEGA Gene Model | MGI Sequence Detail	19695	C57BL/6J
transcript	OTTMUST00000078711	VEGA | MGI Sequence Detail	1769	Not Applicable
polypeptide	OTTMUSP00000041895	VEGA | MGI Sequence Detail	380	Not Applicable

All sequences(31) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(85 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009169	Calreticulin
InterPro	IPR001580	Calreticulin/calnexin
InterPro	IPR018124	Calreticulin/calnexin, conserved site
InterPro	IPR009033	Calreticulin/calnexin, P
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
Protein Ontology	PR:000004985	calreticulin-3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:182133 Tokuhiro K, et al., Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3850-5
All references(32)

Other accession IDs

MGI:1924129