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Rhobtb3 Gene Detail
Summary
  • Symbol
    Rhobtb3
  • Name
    Rho-related BTB domain containing 3
  • Synonyms
    1700040C17Rik, 2610033K01Rik, 4930503C18Rik, mKIAA0878
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920546
    NCBI Gene: 73296
  • Gene Overview
    MyGene.info: RHOBTB3
Location & Maps
more
  • Sequence Map
    Chr13:75869537-75943925 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74389 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.95 cM, cytoband C1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RHOBTB3, Rho related BTB domain containing 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RHOBTB3, Rho related BTB domain containing 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 22836
    neXtProt AC: NX_O94955

  • Chr Location
    5q15; chr5:95731066-95796367 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 1 allele in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Rhobtb3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit preweaning lethality, reduced body weight and slightly reduced organ weights that varies by sex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023271 VEGA Gene Model | MGI Sequence Detail 74389 C57BL/6J ±  kb
transcript OTTMUST00000056338 VEGA | MGI Sequence Detail 4980 Not Applicable  
polypeptide OTTMUSP00000027066 VEGA | MGI Sequence Detail 611 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    912 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    cDNA 57
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1916481, MGI:1922044, MGI:2145203, MGI:2145421
References
more
  • Summaries
    All 42
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:735 Noonan DM, et al., The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule. J Biol Chem. 1991 Dec 5;266(34):22939-47
  • Latest
    J:226884 Lutz J, et al., Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Histochem Cell Biol. 2014 Nov;142(5):511-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory