Ddit4l MGI Mouse Gene Detail - MGI:1920534 - DNA-damage-inducible transcript 4-like

Symbol

Ddit4l
Name

DNA-damage-inducible transcript 4-like
Synonyms

1700037B15Rik, 1700108M02Rik, REDD2, RTP801L

Feature Type

protein coding gene
IDs

MGI:1920534
NCBI Gene: 73284
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:137329433-137334093 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 63.81 cM
Mapping Data

2 experiments

SNPs within 2kb

215 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920534	protein coding gene	Chr3:137327373-137334094 (+)
129S1/SvImJ	ENSMUSG00200002544	protein coding gene	Chr3:134131571-134136506 (+)
A/J	ENSMUSG00195003975	protein coding gene	Chr3:134237306-134244280 (+)
AKR/J	ENSMUSG00220002765	protein coding gene	Chr3:132689108-132696083 (+)
BALB/cJ	ENSMUSG00180011153	protein coding gene	Chr3:134151506-134158478 (+)
C3H/HeJ	ENSMUSG00175018774	protein coding gene	Chr3:133754839-133761809 (+)
C57BL/6NJ	ENSMUSG00215015304	protein coding gene	Chr3:134487760-134492681 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025667	protein coding gene	Chr3:130789045-130793814 (+)
CAST/EiJ	ENSTCUG00005027743	protein coding gene	Chr3:134826367-134833326 (+)
CBA/J	ENSMUSG00210031574	protein coding gene	Chr3:134367602-134372533 (+)
DBA/2J	ENSMUSG00185003239	protein coding gene	Chr3:134982352-134989322 (+)
FVB/NJ	ENSMUSG00205024827	protein coding gene	Chr3:133291432-133298407 (+)
JF1/MsJ	ENSUMUG00000004766	protein coding gene	Chr3:133753801-133760772 (+)
LP/J	ENSMUSG00230002304	protein coding gene	Chr3:136945344-136950279 (+)
NOD/ShiLtJ	ENSMUSG00190004594	protein coding gene	Chr3:135364353-135371323 (+)
NZO/HlLtJ	ENSMUSG00225005273	protein coding gene	Chr3:139413314-139418249 (+)
PWK/PhJ	ENSLUMG00010020733	protein coding gene	Chr3:133665372-133672347 (+)
SPRET/EiJ	ENSMSPG00010013680	protein coding gene	Chr3:134830750-134835922 (+)
WSB/EiJ	ENSIUOG00005018011	protein coding gene	Chr3:134520771-134527735 (+)

Human Ortholog

DDIT4L, DNA damage inducible transcript 4 like

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDIT4L, DNA damage inducible transcript 4 like
Synonyms

REDD2, Rtp801L
Links

HGNC:30555

NCBI Gene ID: 115265

UniProt: Q96D03
Chr Location

4q24; chr4:100185870-100190782 (-) GRCh38

MGI Vertebrate Homology

Ddit4l stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DDIT4L
Gene Tree

Ddit4l

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References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Targeted

1
Transgenic

1
Genomic Mutations

2 involving Ddit4l
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

On a standard diet, male mice homozygous for a knock-out allele show a decrease in inguinal white adipose tissue but no major changes in body weight, glucose tolerance or insulin sensitivity. In contrast, males fed a high-fat diet exhibit improved glucose tolerance, increased pancreatic beta-cell mass, decreased beta-cell apoptosis, and elevated plasma insulin levels.

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All GO Annotations

4
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

668
Tissues

19
cDNA Data

29
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

44
RefSeq

2
UniProt

3
CCDS

CCDS17863.1

Ensembl

ENSMUSG00000046818 (Evidence)
NCBI Gene

73284

			Length	Strain/Species	Flank
genomic	73284	NCBI Gene Model \| MGI Sequence Detail	4661	C57BL/6J	± kb
transcript	NM_030143	RefSeq \| MGI Sequence Detail	2721	C57BL/6
polypeptide	Q8VHZ5	UniProt \| EBI \| MGI Sequence Detail	193	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006349 DNA damage-inducible transcript 4-like protein

(term hierarchy)
InterPro Domains

IPR012918 RTP801-like

IPR038281 RTP801-like, C-terminal domain superfamily

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All nucleic 36

cDNA 29

Primer pair 5

Other 2

Microarray probesets 4

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MGI:1925887

Summaries

All 58

Developmental Gene Expression 10

Diseases 1

Gene Ontology 3

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:370104 Yamada Y, et al., Nrf2-and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic beta-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice. J Biol Chem. 2025 May 21;301(6):110271

TSS for Ddit4l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31903	Chr3:137329477-137329488 (+)	50 bp
Tssr31904	Chr3:137329489-137329517 (+)	70 bp
Tssr31905	Chr3:137329530-137329550 (+)	107 bp
Tssr31906	Chr3:137329792-137329823 (+)	375 bp
Tssr31907	Chr3:137329964-137329971 (+)	535 bp
Tssr31908	Chr3:137332391-137332397 (+)	2,961 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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