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Setd7
Gene Detail
Symbol

Name
ID
Setd7
SET domain containing (lysine methyltransferase) 7
MGI:1920501
Synonyms
1600028F23Rik, KMT7, mKIAA1717, Set7, Set7/9
Feature Type
protein coding gene
Genetic Map
Chromosome 3
22.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:51515319-51560879 bp, - strand
From VEGA annotation of GRCm38

  45561 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12741  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SETD7
Protein SuperFamily: histone-lysine N-methyltransferase with SET domain
Gene Tree: Setd7

Human
homologs
SETD7, SET domain containing (lysine methyltransferase) 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 80854
neXtProt AC: NX_Q8WTS6

Human Synonyms: KMT7, SET7, SET7/9, SET9

Human Chr (Location): 4q28; chr4:139495660-139557157 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an allele lacking exon 2 exhibit some prenatal lethality and mouse embryonic fibroblasts exhibit cell cycling defects.
 
Interactions
Setd7 interacts with 460 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cellular response to DNA damage stimulus, chromatin modification, ...
Component chromosome, nucleolus, ...
Function chromatin binding, histone-lysine N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (94)    Tissues (94)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(78)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase setd7 ; ZFIN setd7    NEW 
Molecular
reagents
All nucleic(78) cDNA(78)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017099 (Evidence)
Ensembl Gene Model ENSMUSG00000037111 (Evidence)
Entrez Gene 73251 (Evidence)
UniGene 192111
DoTS DT.94250919, DT.94267962
NIA Mouse Gene Index U364802, U024016
EC 2.1.1.43
Consensus CDS Project CCDS17341.1
International Mouse Phenotyping Consortium Status Setd7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017099 VEGA Gene Model | MGI Sequence Detail 45561 C57BL/6J ±  kb
transcript OTTMUST00000041418 VEGA | MGI Sequence Detail 7411 Not Applicable 
polypeptide OTTMUSP00000018581 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017155 Histone-lysine N-methyltransferase, SET
InterPro IPR003409 MORN motif
InterPro IPR001214 SET domain
Protein Ontology PR:000014722 histone-lysine N-methyltransferase SETD7
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215367 Shao GB, et al., Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014 Aug;50(7):603-13
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory