Setd7
Gene Detail

Symbol Name ID

Setd7 SET domain containing (lysine methyltransferase) 7 MGI:1920501

Synonyms

1600028F23Rik, KMT7, mKIAA1717, Set7, Set7/9

Feature Type

protein coding gene

Genetic Map

Chromosome 3

22.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:51515319-51560878 bp, - strand From VEGA annotation of GRCm38   45560 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12741  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: histone-lysine N-methyltransferase with SET domain
Gene Tree: Setd7

Human homologs

Human Homolog		SETD7, SET domain containing (lysine methyltransferase) 7
NCBI Gene ID		80854
neXtProt AC		NX_Q8WTS6
Human Synonyms		KMT7, SET7, SET7/9, SET9
Human Chr (Location)		4q28; chr4:140427192-140477577 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for an allele lacking exon 2 exhibit some prenatal lethality and mouse embryonic fibroblasts exhibit cell cycling defects.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	chromatin modification, histone lysine methylation, ...
Component	chromosome, nucleus
Function	histone-lysine N-methyltransferase activity, methyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (94)    Tissues (94)    Images (7)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(78)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(78) cDNA(78)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017099 (Evidence)
Ensembl Gene Model	ENSMUSG00000037111 (Evidence)
Entrez Gene	73251 (Evidence)
UniGene	192111
DoTS	DT.94250919, DT.94267962
NIA Mouse Gene Index	U024016, U364802
EC	2.1.1.43
Consensus CDS Project	CCDS17341.1
International Mouse Knockout Project Status	Setd7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017099	VEGA Gene Model | MGI Sequence Detail	45560	C57BL/6J
transcript	OTTMUST00000041418	VEGA | MGI Sequence Detail	7410	Not Applicable
polypeptide	OTTMUSP00000018581	VEGA | MGI Sequence Detail	366	Not Applicable

All sequences(32) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(159 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017155	Histone-lysine N-methyltransferase, SET
InterPro	IPR003409	MORN motif
InterPro	IPR001214	SET domain
Protein Ontology	PR:000014722	histone-lysine N-methyltransferase SETD7

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194231 Wang D, et al., Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5516-21
All references(42)