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Setd7
Gene Detail
Symbol

Name
ID
Setd7
SET domain containing (lysine methyltransferase) 7
MGI:1920501
Synonyms
1600028F23Rik, KMT7, mKIAA1717, Set7, Set7/9
Feature Type
protein coding gene
Genetic Map
Chromosome 3
22.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:51515319-51560878 bp, - strand
From VEGA annotation of GRCm38

  45560 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12741  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histone-lysine N-methyltransferase with SET domain
Gene Tree: Setd7

Human
homologs
Human Homolog SETD7, SET domain containing (lysine methyltransferase) 7
NCBI Gene ID 80854
neXtProt AC  NX_Q8WTS6
Human Synonyms  KMT7, SET7, SET7/9, SET9
Human Chr (Location)  4q28; chr4:139506038-139556423 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an allele lacking exon 2 exhibit some prenatal lethality and mouse embryonic fibroblasts exhibit cell cycling defects.
 
Interactions
Setd7 interacts with 461 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cellular response to DNA damage stimulus, chromatin modification, ...
Component chromosome, nucleus
Function chromatin binding, histone-lysine N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (94)    Tissues (94)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(78)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017099 (Evidence)
Ensembl Gene ModelENSMUSG00000037111 (Evidence)
Entrez Gene73251 (Evidence)
UniGene192111
DoTSDT.94267962, DT.94250919
NIA Mouse Gene IndexU364802, U024016
EC2.1.1.43
Consensus CDS ProjectCCDS17341.1
International Mouse Knockout Project StatusSetd7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017099 VEGA Gene Model | MGI Sequence Detail 45560 C57BL/6J ±  kb
transcript OTTMUST00000041418 VEGA | MGI Sequence Detail 7410 Not Applicable 
polypeptide OTTMUSP00000018581 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017155 Histone-lysine N-methyltransferase, SET
InterPro IPR003409 MORN motif
InterPro IPR001214 SET domain
Protein Ontology PR:000014722 histone-lysine N-methyltransferase SETD7
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:214816 Barsyte-Lovejoy D, et al., (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12853-8
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory