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Bmper Gene Detail
Summary
  • Symbol
    Bmper
  • Name
    BMP-binding endothelial regulator
  • Synonyms
    3110056H04Rik, Crim3, crossveinless-2, Cv2, CV-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920480
    NCBI Gene: 73230
  • Gene Overview
    MyGene.info: BMPER
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:23223076-23485200 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      262125 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 9.55 cM, cytoband A4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BMPER, BMP binding endothelial regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMPER, BMP binding endothelial regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRIM3, CV2, CV-2
  • Links
    NCBI Gene ID: 168667
    neXtProt AC: NX_Q8N8U9
    UniProt: Q8N8U9

  • Chr Location
    7p14.3; chr7:33904911-34155872 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12494
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BMPER
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 4 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    3 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out mutation exhibit neonatal lethality associated with abnormal lung and skeleton development. Mice heterozygous for a null allele exhibit abnromal lung development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031963 Ensembl Gene Model | MGI Sequence Detail 262125 C57BL/6J ±  kb
    transcript ENSMUST00000071982 Ensembl | MGI Sequence Detail 3791 Not Applicable  
    polypeptide ENSMUSP00000071872 Ensembl | MGI Sequence Detail 685 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1176 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 27
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:257520 Sardella C, et al., Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion. J Invest Dermatol. 2018 Mar;138(3):500-510

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory