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Bmper
Gene Detail
Symbol

Name
ID
Bmper
BMP-binding endothelial regulator
MGI:1920480
Synonyms
3110056H04Rik, Crim3, crossveinless-2, Cv2, CV-2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
9.55 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:23223076-23485202 bp, + strand
From Ensembl annotation of GRCm38

  262127 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12494  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Bmper

Human
homologs
Human Homolog BMPER, BMP binding endothelial regulator
NCBI Gene ID 168667
neXtProt AC  NX_Q8N8U9
Human Synonyms  CRIM3, CV2, CV-2
Human Chr (Location)  7p14.3; chr7:33904911-34155872 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human BMPER
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out mutation exhibit neonatal lethality associated with abnormal lung and skeleton development. Mice heterozygous for a null allele exhibit abnromal lung development.
 
Phenotype Images(3)
Interactions
Bmper interacts with 259 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (21 records)
Data Summary: Results (127)    Tissues (99)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 113
In situ reporter (knock in) 2
Northern blot 12
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000031963 (Evidence)
Entrez Gene73230 (Evidence)
UniGene335020
DFCITC1617923, TC1582973
DoTSDT.91310063, DT.55242383
NIA Mouse Gene IndexU010170
Consensus CDS ProjectCCDS22929.1
International Mouse Knockout Project StatusBmper
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031963 Ensembl Gene Model | MGI Sequence Detail 262127 C57BL/6J ±  kb
transcript ENSMUST00000071982 Ensembl | MGI Sequence Detail 3793 Not Applicable 
polypeptide ENSMUSP00000071872 Ensembl | MGI Sequence Detail 685 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(1179 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1181)
Protein-related
information
ResourceIDDescription
InterPro IPR002919 Trypsin Inhibitor-like, cysteine rich domain
InterPro IPR014853 Uncharacterised domain, cysteine-rich
InterPro IPR001007 von Willebrand factor, type C
InterPro IPR001846 von Willebrand factor, type D domain
Protein Ontology PR:000004775 BMP-binding endothelial regulator protein
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206881 Dyer L, et al., BMPER-induced BMP signaling promotes coronary artery remodeling. Dev Biol. 2014 Feb 15;386(2):385-94
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory