Sppl2b MGI Mouse Gene Detail - MGI:1920468 - signal peptide peptidase like 2B

Symbol

Sppl2b
Name

signal peptide peptidase like 2B
Synonyms

3110056O03Rik

Feature Type

protein coding gene
IDs

MGI:1920468
NCBI Gene: 73218
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr10:80691109-80704542 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

357 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920468	protein coding gene	Chr10:80691067-80704542 (+)
129S1/SvImJ	ENSMUSG00200046442	protein coding gene	Chr10:77317676-77333555 (+)
A/J	ENSMUSG00195043306	protein coding gene	Chr10:77712899-77728784 (+)
AKR/J	ENSMUSG00220047794	protein coding gene	Chr10:77310586-77326471 (+)
BALB/cJ	ENSMUSG00180049446	protein coding gene	Chr10:77723366-77739250 (+)
C3H/HeJ	ENSMUSG00175048544	protein coding gene	Chr10:77594107-77609997 (+)
C57BL/6NJ	ENSMUSG00215049253	protein coding gene	Chr10:77335962-77351846 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015608	protein coding gene	Chr10:74858902-74871883 (+)
CAST/EiJ	ENSTCUG00005050612	protein coding gene	Chr10:77223433-77238841 (+)
CBA/J	ENSMUSG00210047018	protein coding gene	Chr10:77450149-77466033 (+)
DBA/2J	ENSMUSG00185049328	protein coding gene	Chr10:77792602-77808486 (+)
FVB/NJ	ENSMUSG00205037692	protein coding gene	Chr10:77505376-77521260 (+)
JF1/MsJ	ENSUMUG00000048973	protein coding gene	Chr10:79026242-79039691 (+)
LP/J	ENSMUSG00230049472	protein coding gene	Chr10:79562200-79578084 (+)
NOD/ShiLtJ	ENSMUSG00190051299	protein coding gene	Chr10:77706300-77722184 (+)
NZO/HlLtJ	ENSMUSG00225052140	protein coding gene	Chr10:83848725-83864614 (+)
PWK/PhJ	ENSLUMG00010043673	protein coding gene	Chr10:77386837-77402753 (+)
SPRET/EiJ	ENSMSPG00010040937	protein coding gene	Chr10:79001050-79015142 (+)
WSB/EiJ	ENSIUOG00005049290	protein coding gene	Chr10:77451396-77467510 (+)

Human Ortholog

SPPL2B, signal peptide peptidase like 2B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPPL2B, signal peptide peptidase like 2B
Synonyms

IMP-4, IMP4, PSH4, PSL1
Links

HGNC:30627

NCBI Gene ID: 56928

UniProt: Q8TCT7
Chr Location

19p13.3; chr19:2328613-2355095 (+) GRCh38

MGI Vertebrate Homology

Sppl2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPPL2B
Gene Tree

Sppl2b

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Sppl2b
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele are viable and overtly normal with no apparent defects in B cell and dendritic cell homeostasis.

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All GO Annotations

55
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

599
Tissues

2
cDNA Data

66
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sppl2b

ZFIN sppl2b

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All Sequences

109
RefSeq

40
UniProt

6
CCDS

CCDS35988.1

Ensembl

ENSMUSG00000035206 (Evidence)
NCBI Gene

73218

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035206	Ensembl Gene Model \| MGI Sequence Detail	13434	C57BL/6J	± kb
transcript	ENSMUST00000035597	Ensembl \| MGI Sequence Detail	2869	Not Applicable
polypeptide	ENSMUSP00000036289	Ensembl \| MGI Sequence Detail	578	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015564 signal peptide peptidase-like 2B

(term hierarchy)
EC

3.4.23.-
InterPro Domains

IPR003137 PA domain

IPR046450 PA domain superfamily

IPR007369 Peptidase A22B, signal peptide peptidase

IPR006639 Presenilin/signal peptide peptidase
GlyGen

Q3TD49 5 sites, 1 N-linked glycan (4 sites), 1 O-linked glycan (1 site)

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All nucleic 66

cDNA 66

Microarray probesets 3

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MGI:2143859

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:367703 Held S, et al., Physiological shedding and C-terminal proteolytic processing of TMEM106B. Cell Rep. 2025 Jan 28;44(1):115107

TSS for Sppl2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3280	Chr10:80691099-80691114 (+)	-2 bp
Tssr94631	Chr10:80691123-80691156 (+)	31 bp
Tssr94632	Chr10:80691157-80691172 (+)	56 bp
Tssr94633	Chr10:80692948-80692971 (+)	1,851 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24