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Sppl2b Gene Detail
Summary
  • Symbol
    Sppl2b
  • Name
    signal peptide peptidase like 2B
  • Synonyms
    3110056O03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920468
    NCBI Gene: 73218
  • Gene Overview
    MyGene.info: SPPL2B
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80855275-80868708 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920468
protein coding gene Chr10:80855246-80868708 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017525
protein coding gene Chr10:81519396-81532822 (+)
A/J MGP_AJ_G0017503
protein coding gene Chr10:78647512-78660942 (+)
AKR/J MGP_AKRJ_G0017464
protein coding gene Chr10:80802724-80816154 (+)
BALB/cJ MGP_BALBcJ_G0017465
protein coding gene Chr10:78863487-78877185 (+)
C3H/HeJ MGP_C3HHeJ_G0017288
protein coding gene Chr10:80889855-80906384 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017919
protein coding gene Chr10:84315771-84331454 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015608
protein coding gene Chr10:74858902-74871883 (+)
CAST/EiJ MGP_CASTEiJ_G0016855
protein coding gene Chr10:81122363-81135556 (+)
CBA/J MGP_CBAJ_G0017260
protein coding gene Chr10:87590359-87606901 (+)
DBA/2J MGP_DBA2J_G0017366
protein coding gene Chr10:77845907-77859130 (+)
FVB/NJ MGP_FVBNJ_G0017360
protein coding gene Chr10:77079044-77092631 (+)
LP/J MGP_LPJ_G0017437
protein coding gene Chr10:81976804-81991457 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017386
protein coding gene Chr10:89502258-89515669 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017960
protein coding gene Chr10:80798474-80811904 (+)
PWK/PhJ MGP_PWKPhJ_G0016636
protein coding gene Chr10:77738881-77753257 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016426
protein coding gene Chr10:79747704-79760669 (+)
WSB/EiJ MGP_WSBEiJ_G0016915
protein coding gene Chr10:80835016-80851806 (+)



Homology
more
  • Human Ortholog
    SPPL2B, signal peptide peptidase like 2B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPPL2B, signal peptide peptidase like 2B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMP4, IMP-4, PSH4, PSL1
  • Links
    NCBI Gene ID: 56928
    neXtProt AC: NX_Q8TCT7
    UniProt: Q8TCT7

  • Chr Location
    19p13.3; chr19:2328571-2355102 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    11 phenotype references
Mice homozygous for a gene trapped allele are viable and overtly normal with no apparent defects in B cell and dendritic cell homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035206 Ensembl Gene Model | MGI Sequence Detail 13434 C57BL/6J ±  kb
transcript ENSMUST00000035597 Ensembl | MGI Sequence Detail 2869 Not Applicable  
polypeptide ENSMUSP00000036289 Ensembl | MGI Sequence Detail 578 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    cDNA 66

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143859
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:213519 Schneppenheim J, et al., The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo. Mol Cell Biol. 2014 Apr;34(8):1398-411

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory