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Fezf1 Gene Detail
Summary
  • Symbol
    Fezf1
  • Name
    Fez family zinc finger 1
  • Synonyms
    3110069A13Rik, Fez, Zfp312-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920441
    NCBI Gene: 73191
  • Gene Overview
    MyGene.info: FEZF1
Location & Maps
more
  • Sequence Map
    Chr6:23245044-23248362 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3319 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 10.55 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FEZF1, FEZ family zinc finger 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FEZF1, FEZ family zinc finger 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FEZ, HH22, ZNF312B
  • Links
    NCBI Gene ID: 389549
    neXtProt AC: NX_A0PJY2

  • Chr Location
    7q31.32; chr7:122301309-122311853 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FEZF1 associations

Human Disease Mouse Models
       Hypogonadotropic Hypogonadism 22 with or without Anosmia; HH22   OMIM: 616030
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 5 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a null mutation of this gene display neonatal lethality, impaired olfactory bulb development and impaired olfactory bulb interneuron migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055954 VEGA Gene Model | MGI Sequence Detail 3319 C57BL/6J ±  kb
transcript OTTMUST00000138429 VEGA | MGI Sequence Detail 2409 Not Applicable  
polypeptide OTTMUSP00000072789 VEGA | MGI Sequence Detail 475 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    52 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 46
    Developmental Gene Expression 20
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231879 Sokolowski K, et al., Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei. Neural Dev. 2016;11(1):12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory