About   Help   FAQ
Fezf1 Gene Detail
Summary
  • Symbol
    Fezf1
  • Name
    Fez family zinc finger 1
  • Synonyms
    3110069A13Rik, Fez, Zfp312-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920441
    NCBI Gene: 73191
  • Gene Overview
    MyGene.info: FEZF1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:23245044-23248362 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 10.55 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920441
protein coding gene Chr6:23245044-23252463 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030487
protein coding gene Chr6:20782103-20785385 (-)
A/J MGP_AJ_G0030460
protein coding gene Chr6:19936367-19939681 (-)
AKR/J MGP_AKRJ_G0030387
protein coding gene Chr6:20586007-20589325 (-)
BALB/cJ MGP_BALBcJ_G0030470
protein coding gene Chr6:20022648-20025946 (-)
C3H/HeJ MGP_C3HHeJ_G0030183
protein coding gene Chr6:20528332-20531648 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030924
protein coding gene Chr6:21438530-21441868 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028135
protein coding gene Chr6:18461040-18463923 (-)
CAST/EiJ MGP_CASTEiJ_G0029585
protein coding gene Chr6:20452929-20458479 (-)
CBA/J MGP_CBAJ_G0030161
protein coding gene Chr6:22149781-22153093 (-)
DBA/2J MGP_DBA2J_G0030305
protein coding gene Chr6:19858419-19862057 (-)
FVB/NJ MGP_FVBNJ_G0030259
protein coding gene Chr6:19617073-19620373 (-)
LP/J MGP_LPJ_G0030392
protein coding gene Chr6:20919031-20922309 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030295
protein coding gene Chr6:24026843-24030216 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030954
protein coding gene Chr6:20527563-20530863 (-)
PWK/PhJ MGP_PWKPhJ_G0029299
protein coding gene Chr6:19478088-19481502 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029135
protein coding gene Chr6:20235712-20239015 (-)
WSB/EiJ MGP_WSBEiJ_G0029661
protein coding gene Chr6:20430032-20433330 (-)



Homology
more
  • Human Ortholog
    FEZF1, FEZ family zinc finger 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FEZF1, FEZ family zinc finger 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FEZ, HH22, ZNF312B
  • Links
    NCBI Gene ID: 389549
    neXtProt AC: NX_A0PJY2
    UniProt: A0PJY2

  • Chr Location
    7q31.32; chr7:122300939-122311855 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human FEZF1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 5 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation of this gene display neonatal lethality, impaired olfactory bulb development and impaired olfactory bulb interneuron migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029697 Ensembl Gene Model | MGI Sequence Detail 3319 C57BL/6J ±  kb
    transcript ENSMUST00000031709 Ensembl | MGI Sequence Detail 2409 Not Applicable  
    polypeptide ENSMUSP00000031709 Ensembl | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 21
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:256883 Zhou J, et al., Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Biochim Biophys Acta. 2017 Dec;1860(12):1159-1168

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory