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Nfatc4
Gene Detail
 Symbol
Name
ID
Nfatc4
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
MGI:1920431
Synonyms 3110041H08Rik
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:55824795-55833943 bp, + strand
From NCBI annotation of GRCm38

  9149 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3349  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Nfatc4

Human
homologs
Human Homolog NFATC4, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NCBI Gene ID 4776
neXtProt AC  NX_Q14934
Human Synonyms  NFAT3, NF-AT3, NF-ATC4
Human Chr (Location)  14q11.2; chr14:24366911-24379604 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and overtly normal and exhibit normal embryonic heart morphology as well as normal pathophysiologic cardiac hypertrophy in response to angiotensin II infusion or aortic banding.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Nfatc4 interacts with 175 markers (Mir15a, Mir23a, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process cell differentiation, cellular respiration, ...
Component cytoplasm, cytosol, ...
Function DNA binding, peroxisome proliferator activated receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (118)    Tissues (94)    Images (8)
Theiler Stages: 15, 17, 19, 21, 23, 24, 28
Assay TypeResults
RNA in situ 116
RT-PCR 2
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) cDNA(46) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000023411 (Evidence)
Entrez Gene73181 (Evidence)
UniGene27908
DFCITC1581336, TC1600964, TC1627487
DoTSDT.101407580, DT.99842291, DT.99842293
NIA Mouse Gene IndexU015669
Consensus CDS ProjectCCDS27132.1, CCDS49500.1
International Mouse Knockout Project StatusNfatc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 73181 NCBI Gene Model | MGI Sequence Detail 9149 C57BL/6J ±  kb
transcript NM_001168346 RefSeq | MGI Sequence Detail 4036 C57BL/6 
polypeptide Q8K120 UniProt | EBI | MGI Sequence Detail 901 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR008366 Nuclear factor of activated T cells (NFAT)
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000011167 nuclear factor of activated T-cells, cytoplasmic 4
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205486 Kurabayashi N, et al., Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells. Genes Dev. 2013 Dec 15;27(24):2708-21
All references(73)
Other
accession IDs
MGI:2145795, MGI:2145827

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory