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Nfatc4 Gene Detail
Summary
  • Symbol
    Nfatc4
  • Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
  • Synonyms
    3110041H08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920431
    NCBI Gene: 73181
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56062252-56071400 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920431
protein coding gene Chr14:56060601-56071400 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021373
protein coding gene Chr14:49875410-49884425 (+)
A/J MGP_AJ_G0021332
protein coding gene Chr14:48870172-48879321 (+)
AKR/J MGP_AKRJ_G0021308
protein coding gene Chr14:50633312-50642943 (+)
BALB/cJ MGP_BALBcJ_G0021336
protein coding gene Chr14:48846352-48855502 (+)
C3H/HeJ MGP_C3HHeJ_G0021116
protein coding gene Chr14:50317043-50326195 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021774
protein coding gene Chr14:52369945-52379082 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019321
protein coding gene Chr14:47234858-47243940 (+)
CAST/EiJ MGP_CASTEiJ_G0020635
protein coding gene Chr14:46569922-46579029 (+)
CBA/J MGP_CBAJ_G0021083
protein coding gene Chr14:53935912-53945046 (+)
DBA/2J MGP_DBA2J_G0021204
protein coding gene Chr14:48588670-48597796 (+)
FVB/NJ MGP_FVBNJ_G0021186
protein coding gene Chr14:48039369-48048488 (+)
LP/J MGP_LPJ_G0021278
protein coding gene Chr14:50915138-50924221 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021210
protein coding gene Chr14:53291312-53300428 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021801
protein coding gene Chr14:49810953-49820150 (+)
PWK/PhJ MGP_PWKPhJ_G0020382
protein coding gene Chr14:45128454-45137753 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020210
protein coding gene Chr14:45805984-45814969 (+)
WSB/EiJ MGP_WSBEiJ_G0020688
protein coding gene Chr14:50089777-50098864 (+)



Homology
more
  • Human Ortholog
    NFATC4, nuclear factor of activated T cells 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFATC4, nuclear factor of activated T cells 4
  • Synonyms
    NFAT3, NF-AT3, NF-ATC4
  • Links
    NCBI Gene ID: 4776
    neXtProt AC: NX_Q14934
    UniProt: Q14934

  • Chr Location
    14q12; chr14:24365673-24379604 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human NFATC4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    39 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and overtly normal and exhibit normal embryonic heart morphology as well as normal pathophysiologic cardiac hypertrophy in response to angiotensin II infusion or aortic banding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73181 NCBI Gene Model | MGI Sequence Detail 9149 C57BL/6J ±  kb
    transcript NM_001168346 RefSeq | MGI Sequence Detail 4036 C57BL/6  
    polypeptide Q8K120 UniProt | EBI | MGI Sequence Detail 901 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000011167 nuclear factor of activated T-cells, cytoplasmic 4
    • InterPro Domains
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
      IPR002909 IPT domain
      IPR008366 Nuclear factor of activated T cells (NFAT)
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR032397 Rel homology dimerisation domain
      IPR011539 Rel homology domain, DNA-binding domain
      IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 48
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145795, MGI:2145827
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 31
      Diseases 1
      Gene Ontology 23
      Phenotypes 24
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory