About   Help   FAQ
Nfatc4 Gene Detail
Summary
  • Symbol
    Nfatc4
  • Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
  • Synonyms
    3110041H08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920431
    NCBI Gene: 73181
  • Gene Overview
    MyGene.info: NFATC4
Location & Maps
more
  • Sequence Map
    Chr14:55824795-55833943 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9149 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NFATC4, nuclear factor of activated T-cells 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NFATC4, nuclear factor of activated T-cells 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NFAT3, NF-AT3, NF-ATC4
  • Links
    NCBI Gene ID: 4776
    neXtProt AC: NX_Q14934

  • Chr Location
    14q11.2; chr14:24366911-24379604 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    39 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    4
  • Genomic Mutations
    1 involving Nfatc4
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable and overtly normal and exhibit normal embryonic heart morphology as well as normal pathophysiologic cardiac hypertrophy in response to angiotensin II infusion or aortic banding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 73181 NCBI Gene Model | MGI Sequence Detail 9149 C57BL/6J ±  kb
transcript NM_001168346 RefSeq | MGI Sequence Detail 4036 C57BL/6  
polypeptide Q8K120 UniProt | EBI | MGI Sequence Detail 901 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    98 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011167 nuclear factor of activated T-cells, cytoplasmic 4
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR013783 Immunoglobulin-like fold
    IPR002909 IPT domain
    IPR008366 Nuclear factor of activated T cells (NFAT)
    IPR008967 p53-like transcription factor, DNA-binding
    IPR032397 Rel homology dimerisation domain
    IPR011539 Rel homology domain (RHD), DNA-binding domain
Molecular
Reagents
less
  • All nucleic 47
    cDNA 46
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145795, MGI:2145827
References
more
  • Summaries
    All 77
    Developmental Gene Expression 25
    Diseases 1
    Gene Ontology 18
    Phenotypes 18
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231817 Matsumoto S, et al., Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development. J Neurosci. 2016 Apr 27;36(17):4744-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory