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Tbkbp1 Gene Detail
Summary
  • Symbol
    Tbkbp1
  • Name
    TBK1 binding protein 1
  • Synonyms
    3110043L15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920424
    NCBI Gene: 73174
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97026997-97042321 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 60.95 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920424
 protein coding gene Chr11:97026997-97042332 (-)
129S1/SvImJ ENSMUSG00200048902
 protein coding gene Chr11:94273865-94289190 (-)
A/J ENSMUSG00195049097
 protein coding gene Chr11:93998534-94013862 (-)
AKR/J ENSMUSG00220049850
 protein coding gene Chr11:94257654-94272983 (-)
BALB/cJ ENSMUSG00180042812
 protein coding gene Chr11:94256360-94271685 (-)
C3H/HeJ ENSMUSG00175039079
 protein coding gene Chr11:94253942-94269267 (-)
C57BL/6NJ ENSMUSG00215052460
 protein coding gene Chr11:93844771-93860097 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017049
 protein coding gene Chr11:92907952-92923370 (-)
CAST/EiJ ENSTCUG00005045321
 protein coding gene Chr11:93702253-93717667 (-)
CBA/J ENSMUSG00210053348
 protein coding gene Chr11:93960706-93976035 (-)
DBA/2J ENSMUSG00185040757
 protein coding gene Chr11:94303861-94319186 (-)
FVB/NJ ENSMUSG00205047146
 protein coding gene Chr11:94158588-94173919 (-)
JF1/MsJ ENSUMUG00000036620
 protein coding gene Chr11:94613897-94629338 (-)
LP/J ENSMUSG00230050462
 protein coding gene Chr11:95356850-95372179 (-)
NOD/ShiLtJ ENSMUSG00190050129
 protein coding gene Chr11:94348516-94363845 (-)
NZO/HlLtJ ENSMUSG00225052350
 protein coding gene Chr11:97412144-97427471 (-)
PWK/PhJ ENSLUMG00010048317
 protein coding gene Chr11:94157187-94172618 (-)
SPRET/EiJ ENSMSPG00010048535
 protein coding gene Chr11:94655978-94671363 (-)
WSB/EiJ ENSIUOG00005046346
 protein coding gene Chr11:94104398-94119751 (-)



Homology
more
  • Human Ortholog
    TBKBP1, TBK1 binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBKBP1, TBK1 binding protein 1
  • Synonyms
    ProSAPiP2, SINTBAD
  • Links
    NCBI Gene ID: 9755
    UniProt: A7MCY6

  • Chr Location
    17q21.32; chr17:47694030-47712063 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal GM-CSF-derived bone marrow-derived dendritic cell differentiation and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    15
  • cDNA Data
    28
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038517 Ensembl Gene Model | MGI Sequence Detail 15325 C57BL/6J ±  kb
transcript ENSMUST00000107614 Ensembl | MGI Sequence Detail 2391 Not Applicable  
polypeptide ENSMUSP00000103239 Ensembl | MGI Sequence Detail 611 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 17
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory