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Tbkbp1 Gene Detail
Summary
  • Symbol
    Tbkbp1
  • Name
    TBK1 binding protein 1
  • Synonyms
    3110043L15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920424
    NCBI Gene: 73174
Location & Maps
more
  • Sequence Map
    Chr11:97136173-97151495 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15323 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 60.95 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TBKBP1, TBK1 binding protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBKBP1, TBK1 binding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ProSAPiP2, SINTBAD
  • Links
    NCBI Gene ID: 9755
    neXtProt AC: NX_A7MCY6

  • Chr Location
    17q21.32; chr17:47694065-47712063 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8820
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TBKBP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    2
  • Targeted
    5
  • Genomic Mutations
    1 involving Tbkbp1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit normal GM-CSF-derived bone marrow-derived dendritic cell differentiation and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002304 VEGA Gene Model | MGI Sequence Detail 15323 C57BL/6J ±  kb
transcript OTTMUST00000004590 VEGA | MGI Sequence Detail 2391 Not Applicable  
polypeptide OTTMUSP00000002202 VEGA | MGI Sequence Detail 611 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016131 TANK-binding kinase 1-binding protein 1
  • InterPro Domains
    IPR024581 Tbk1/Ikki binding domain
Molecular
Reagents
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  • All nucleic 27
    cDNA 27

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:204786 Fukasaka M, et al., Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation. J Immunol. 2013 Jun 1;190(11):5702-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory