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Exo5 Gene Detail
Summary
  • Symbol
    Exo5
  • Name
    exonuclease 5
  • Synonyms
    3110037I16Rik, Dem1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920422
    NCBI Gene: 73172
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:120921202-120925005 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 56.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920422
protein coding gene Chr4:120921196-120925017 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028716
protein coding gene Chr4:122221395-122227149 (-)
A/J MGP_AJ_G0028676
protein coding gene Chr4:117397091-117400905 (-)
AKR/J MGP_AKRJ_G0028629
protein coding gene Chr4:119988878-119992519 (-)
BALB/cJ MGP_BALBcJ_G0028699
protein coding gene Chr4:118011259-118015047 (-)
C3H/HeJ MGP_C3HHeJ_G0028414
protein coding gene Chr4:121513693-121517481 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029140
protein coding gene Chr4:126827483-126832524 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026417
protein coding gene Chr4:111445355-111448699 (-)
CAST/EiJ MGP_CASTEiJ_G0027845
protein coding gene Chr4:118882413-118888240 (-)
CBA/J MGP_CBAJ_G0028381
protein coding gene Chr4:130265137-130268925 (-)
DBA/2J MGP_DBA2J_G0028528
protein coding gene Chr4:117975769-117979557 (-)
FVB/NJ MGP_FVBNJ_G0028494
protein coding gene Chr4:116498918-116502649 (-)
LP/J MGP_LPJ_G0028628
protein coding gene Chr4:122347526-122351348 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028522
protein coding gene Chr4:135077501-135081046 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029177
protein coding gene Chr4:121055715-121059539 (-)
PWK/PhJ MGP_PWKPhJ_G0027568
protein coding gene Chr4:114923655-114927758 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027394
protein coding gene Chr4:117474107-117480245 (-)
WSB/EiJ MGP_WSBEiJ_G0027925
protein coding gene Chr4:121075055-121079929 (-)



Homology
more
  • Human Ortholog
    EXO5, exonuclease 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    EXO5, exonuclease 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf176, DEM1, Exo V, hExo5
  • Links
    NCBI Gene ID: 64789
    neXtProt AC: NX_Q9H790
    UniProt: Q9H790

  • Chr Location
    1p34.2; chr1:40508719-40516556 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Exo5
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 73172 NCBI Gene Model | MGI Sequence Detail 3804 C57BL/6J ±  kb
transcript NM_028457 RefSeq | MGI Sequence Detail 1990 C57BL/6  
polypeptide Q9CXP9 UniProt | EBI | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140535
References
more
  • Summaries
    All 32
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:196213 Sparks JL, et al., Human exonuclease 5 is a novel sliding exonuclease required for genome stability. J Biol Chem. 2012 Dec 14;287(51):42773-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory