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Trmt10a Gene Detail
Summary
  • Symbol
    Trmt10a
  • Name
    tRNA methyltransferase 10A
  • Synonyms
    3110023L08Rik, Rg9mtd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920421
    NCBI Gene: 108943
Location & Maps
more
  • Sequence Map
    Chr3:138143448-138159821 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16374 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 64.09 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TRMT10A, tRNA methyltransferase 10A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TRMT10A, tRNA methyltransferase 10A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HEL-S-88, MSSGM, MSSGM1, RG9MTD2, TRM10
  • Links
    NCBI Gene ID: 93587
    neXtProt AC: NX_Q8TBZ6

  • Chr Location
    4q23; chr4:99546707-99564057 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TRMT10A associations

Human Disease Mouse Models
       Microcephaly, Short Stature, and Impaired Glucose Metabolism 1; MSSGM1   OMIM: 616033
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    133
  • Chemically induced (other)
    1
  • Gene trapped
    129
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Trmt10a
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit increased circulating magnesium level.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027229 VEGA Gene Model | MGI Sequence Detail 16374 C57BL/6J ±  kb
transcript OTTMUST00000067336 VEGA | MGI Sequence Detail 4025 Not Applicable  
polypeptide OTTMUSP00000033862 VEGA | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    115 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • EC
  • InterPro Domains
    IPR016653 tRNA (guanine(9)-N(1))-methyltransferase TRM10
    IPR007356 tRNA (guanine-N1-)-methyltransferase, eukaryotic
    IPR028564 tRNA methyltransferase TRM10-type domain
    IPR016009 tRNA methyltransferase TRMD/TRM10-type domain
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 6
Other
Accession IDs
less
MGI:3034323
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:200082 White JK, et al., Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell. 2013 Jul 18;154(2):452-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory