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Arhgap8 Gene Detail
Summary
  • Symbol
    Arhgap8
  • Name
    Rho GTPase activating protein 8
  • Synonyms
    3110043J09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920417
    NCBI Gene: 73167
Location & Maps
more
  • Sequence Map
    Chr15:84720083-84772204 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52122 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 39.99 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARHGAP8, Rho GTPase activating protein 8
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ARHGAP8, Rho GTPase activating protein 8
    Orthology source: HomoloGene
  • Synonyms
    BPGAP1, PP610
  • Links
    NCBI Gene ID: 23779
    neXtProt AC: NX_P85298

  • Chr Location
    22q13.31; chr22:44752558-44862784 (+)  GRCh38.p2

  • Human Ortholog
    PRR5-ARHGAP8, PRR5-ARHGAP8 readthrough
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 553158

  • Chr Location
    22q13; chr22:44702198-44862784 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotype references
  • All Mutations and Alleles
    82
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    75
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Arhgap8
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035391 VEGA Gene Model | MGI Sequence Detail 52122 C57BL/6J ±  kb
transcript OTTMUST00000090498 VEGA | MGI Sequence Detail 1464 Not Applicable  
polypeptide OTTMUSP00000049668 VEGA | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    383 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004240 rho GTPase-activating protein 8
  • InterPro Domains
    IPR001251 CRAL-TRIO lipid binding domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146007
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 3
    Phenotypes 24
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory