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Arhgap8 Gene Detail
Summary
  • Symbol
    Arhgap8
  • Name
    Rho GTPase activating protein 8
  • Synonyms
    3110043J09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920417
    NCBI Gene: 73167
  • Gene Overview
    MyGene.info: ARHGAP8
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:84720052-84772207 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 39.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    383 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920417
protein coding gene Chr15:84720034-84772857 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022181
protein coding gene Chr15:85534609-85579938 (+)
A/J MGP_AJ_G0022140
protein coding gene Chr15:82369086-82415514 (+)
AKR/J MGP_AKRJ_G0022115
protein coding gene Chr15:84778029-84830794 (+)
BALB/cJ MGP_BALBcJ_G0022146
protein coding gene Chr15:82501143-82546776 (+)
C3H/HeJ MGP_C3HHeJ_G0021916
protein coding gene Chr15:84741431-84788829 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022591
protein coding gene Chr15:88781244-88834052 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020116
protein coding gene Chr15:78722199-78770202 (+)
CAST/EiJ MGP_CASTEiJ_G0021438
protein coding gene Chr15:85534300-85582985 (+)
CBA/J MGP_CBAJ_G0021883
protein coding gene Chr15:91669788-91723278 (+)
DBA/2J MGP_DBA2J_G0022010
protein coding gene Chr15:81842627-81888392 (+)
FVB/NJ MGP_FVBNJ_G0021989
protein coding gene Chr15:80899475-80951534 (+)
LP/J MGP_LPJ_G0022081
protein coding gene Chr15:85685557-85732610 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022009
protein coding gene Chr15:96455296-96506935 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022606
protein coding gene Chr15:84788116-84837515 (+)
PWK/PhJ MGP_PWKPhJ_G0021179
protein coding gene Chr15:81849877-81897877 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021013
protein coding gene Chr15:84503174-84550125 (+)
WSB/EiJ MGP_WSBEiJ_G0021487
protein coding gene Chr15:85285557-85334384 (+)



Homology
more
  • Human Ortholog
    ARHGAP8, Rho GTPase activating protein 8
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ARHGAP8, Rho GTPase activating protein 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BPGAP1, PP610
  • Links
    NCBI Gene ID: 23779
    neXtProt AC: NX_P85298
    UniProt: P85298

  • Chr Location
    22q13.31; chr22:44752558-44862784 (+)  GRCh38.p7

  • Human Ortholog
    PRR5-ARHGAP8, PRR5-ARHGAP8 readthrough
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 553158

  • Chr Location
    22q13.31; chr22:44702198-44862784 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078954 Ensembl Gene Model | MGI Sequence Detail 52156 C57BL/6J ±  kb
transcript ENSMUST00000168811 Ensembl | MGI Sequence Detail 1464 Not Applicable  
polypeptide ENSMUSP00000130977 Ensembl | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146007
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 2
    Phenotypes 25
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory