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Pak7 Gene Detail
Summary
  • Symbol
    Pak7
  • Name
    p21 (RAC1) activated kinase 7
  • Synonyms
    2900083L08Rik, Pak5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920334
    NCBI Gene: 241656
  • Gene Overview
    MyGene.info: PAK5
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:136081104-136387967 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 67.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1943 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920334
protein coding gene Chr2:136081088-136387967 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026557
protein coding gene Chr2:139843771-140178994 (-)
A/J MGP_AJ_G0026521
protein coding gene Chr2:134157835-134475047 (-)
AKR/J MGP_AKRJ_G0026495
protein coding gene Chr2:138013047-138338156 (-)
BALB/cJ MGP_BALBcJ_G0026533
protein coding gene Chr2:134547521-134857983 (-)
C3H/HeJ MGP_C3HHeJ_G0026276
protein coding gene Chr2:138467929-138791550 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026978
protein coding gene Chr2:144050184-144381826 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024355
protein coding gene Chr2:128721522-129025132 (-)
CAST/EiJ MGP_CASTEiJ_G0025737
protein coding gene Chr2:138813916-139136385 (-)
CBA/J MGP_CBAJ_G0026256
protein coding gene Chr2:149418509-149755060 (-)
DBA/2J MGP_DBA2J_G0026390
protein coding gene Chr2:133537257-133841939 (-)
FVB/NJ MGP_FVBNJ_G0026354
protein coding gene Chr2:132126507-132434010 (-)
LP/J MGP_LPJ_G0026494
protein coding gene Chr2:140013902-140333586 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026374
protein coding gene Chr2:153223856-153581335 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027033
protein coding gene Chr2:138025965-138345793 (-)
PWK/PhJ MGP_PWKPhJ_G0025473
protein coding gene Chr2:133136689-133444922 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025275
protein coding gene Chr2:137127939-137435860 (-)
WSB/EiJ MGP_WSBEiJ_G0025811
protein coding gene Chr2:138947265-139266500 (-)



Homology
more
  • Human Ortholog
    PAK5, p21 (RAC1) activated kinase 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PAK5, p21 (RAC1) activated kinase 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PAK7
  • Links
    NCBI Gene ID: 57144
    neXtProt AC: NX_Q9P286
    UniProt: Q9P286

  • Chr Location
    20p12.2; chr20:9537390-9839042 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit impaired active avoidance learning but are otherwise normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039913 Ensembl Gene Model | MGI Sequence Detail 306864 C57BL/6J ±  kb
transcript ENSMUST00000035264 Ensembl | MGI Sequence Detail 4848 Not Applicable  
polypeptide ENSMUSP00000047285 Ensembl | MGI Sequence Detail 719 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 3
References
more
  • Summaries
    All 59
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 10
    Phenotypes 31
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:210679 Morris DW, et al., An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Hum Mol Genet. 2014 Jun 15;23(12):3316-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory