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Pmpcb
Gene Detail
Symbol

Name
ID
Pmpcb
peptidase (mitochondrial processing) beta
MGI:1920328
Synonyms
3110004O18Rik, MPP11, MPPP52
Feature Type
protein coding gene
Genetic Map
Chromosome 5
9.97 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:21737141-21757152 bp, + strand
From VEGA annotation of GRCm38

  20012 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3160  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PMPCB
Gene Tree: Pmpcb

Human
homologs
PMPCB, peptidase (mitochondrial processing) beta
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9512
neXtProt AC: NX_O75439

Human Synonyms: Beta-MPP, MPP11, MPPB, MPPP52, P-52

Human Chr (Location): 7q22.1; chr7:103297426-103329902 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a transgenic gene disruptin exhibit embryonic lethality at E8.
 
Interactions
Pmpcb interacts with 48 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(113)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pmpcb ; ZFIN pmpcb    NEW 
Molecular
reagents
All nucleic(113) cDNA(113)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000025637 (Evidence)
Ensembl Gene Model ENSMUSG00000029017 (Evidence)
Entrez Gene 73078 (Evidence)
UniGene 301655
DFCI TC1572766, TC1627372
DoTS DT.91404578, DT.97358998
NIA Mouse Gene Index U005339
EC 3.4.24.64
Consensus CDS Project CCDS19106.1
International Mouse Phenotyping Consortium Status Pmpcb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025637 VEGA Gene Model | MGI Sequence Detail 20012 C57BL/6J ±  kb
transcript OTTMUST00000063084 VEGA | MGI Sequence Detail 1615 Not Applicable 
polypeptide OTTMUSP00000031162 VEGA | MGI Sequence Detail 489 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(150 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
InterPro IPR007863 Peptidase M16, C-terminal domain
InterPro IPR011237 Peptidase M16 domain
InterPro IPR011765 Peptidase M16, N-terminal
InterPro IPR001431 Peptidase M16, zinc-binding site
Protein Ontology PR:000012912 mitochondrial-processing peptidase subunit beta
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory