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Pmpcb Gene Detail
Summary
  • Symbol
    Pmpcb
  • Name
    peptidase (mitochondrial processing) beta
  • Synonyms
    3110004O18Rik, MPP11, MPPP52
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920328
    NCBI Gene: 73078
  • Gene Overview
    MyGene.info: PMPCB
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:21737160-21757152 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 9.97 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920328
protein coding gene Chr5:21737141-21757152 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029322
protein coding gene Chr5:19310186-19336330 (+)
A/J MGP_AJ_G0029287
protein coding gene Chr5:18675436-18699961 (+)
AKR/J MGP_AKRJ_G0029238
protein coding gene Chr5:19393084-19417695 (+)
BALB/cJ MGP_BALBcJ_G0029299
protein coding gene Chr5:19113618-19136903 (+)
C3H/HeJ MGP_C3HHeJ_G0029018
protein coding gene Chr5:19458359-19488189 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029752
protein coding gene Chr5:20713539-20738035 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026991
protein coding gene Chr5:16735934-16752665 (+)
CAST/EiJ MGP_CASTEiJ_G0028430
protein coding gene Chr5:18796888-18820485 (+)
CBA/J MGP_CBAJ_G0028985
protein coding gene Chr5:20953091-20974682 (+)
DBA/2J MGP_DBA2J_G0029137
protein coding gene Chr5:18960712-18987544 (+)
FVB/NJ MGP_FVBNJ_G0029095
protein coding gene Chr5:18367002-18391763 (+)
LP/J MGP_LPJ_G0029221
protein coding gene Chr5:19718086-19741230 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029123
protein coding gene Chr5:22221397-22246955 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029785
protein coding gene Chr5:19047448-19068985 (+)
PWK/PhJ MGP_PWKPhJ_G0028153
protein coding gene Chr5:18021128-18042557 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027986
protein coding gene Chr5:18421242-18443935 (+)
WSB/EiJ MGP_WSBEiJ_G0028510
protein coding gene Chr5:19117806-19139813 (+)



Homology
more
  • Human Ortholog
    PMPCB, peptidase, mitochondrial processing beta subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PMPCB, peptidase, mitochondrial processing beta subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Beta-MPP, MPP11, MPPB, MPPP52, P-52
  • Links
    NCBI Gene ID: 9512
    neXtProt AC: NX_O75439
    UniProt: O75439

  • Chr Location
    7q22.1; chr7:103297412-103329902 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruptin exhibit embryonic lethality at E8.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 73078 NCBI Gene Model | MGI Sequence Detail 19993 C57BL/6J ±  kb
transcript NM_028431 RefSeq | MGI Sequence Detail 1596 C57BL/6  
polypeptide Q9CXT8 UniProt | EBI | MGI Sequence Detail 489 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 114
    cDNA 114

    Microarray probesets 4
References
more
  • Summaries
    All 47
    Diseases 1
    Gene Ontology 9
    Phenotypes 17
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:247235 Pandey D, et al., OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase. Circ Res. 2014 Aug 01;115(4):450-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory