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Pmpcb Gene Detail
Summary
  • Symbol
    Pmpcb
  • Name
    peptidase (mitochondrial processing) beta
  • Synonyms
    3110004O18Rik, MPP11, MPPP52
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920328
    NCBI Gene: 73078
  • Gene Overview
    MyGene.info: PMPCB
Location & Maps
more
  • Sequence Map
    Chr5:21737141-21757152 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20012 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PMPCB, peptidase, mitochondrial processing beta subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PMPCB, peptidase, mitochondrial processing beta subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Beta-MPP, MPP11, MPPB, MPPP52, P-52
  • Links
    NCBI Gene ID: 9512
    neXtProt AC: NX_O75439

  • Chr Location
    7q22.1; chr7:103297426-103329902 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from multigenic genotypes
    16 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Gene trapped
    4
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    4 involving Pmpcb
  • Incidental Mutations
Mice homozygous for a transgenic gene disruptin exhibit embryonic lethality at E8.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025637 VEGA Gene Model | MGI Sequence Detail 20012 C57BL/6J ±  kb
transcript OTTMUST00000063084 VEGA | MGI Sequence Detail 1615 Not Applicable  
polypeptide OTTMUSP00000031162 VEGA | MGI Sequence Detail 489 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    131 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 113
    cDNA 113

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Diseases 1
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory