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Srrm3 Gene Detail
Summary
  • Symbol
    Srrm3
  • Name
    serine/arginine repetitive matrix 3
  • Synonyms
    2900083I11Rik, SRm300-like, Srrm2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920309
    NCBI Gene: 58212
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135806890-135874772 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.42 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    292 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920309
protein coding gene Chr5:135806860-135874773 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030191
protein coding gene Chr5:140391372-140469662 (+)
A/J MGP_AJ_G0030159
protein coding gene Chr5:134362109-134434063 (+)
AKR/J MGP_AKRJ_G0030092
protein coding gene Chr5:138711633-138779156 (+)
BALB/cJ MGP_BALBcJ_G0030169
protein coding gene Chr5:135714463-135786024 (+)
C3H/HeJ MGP_C3HHeJ_G0029885
protein coding gene Chr5:139297455-139374332 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030622
protein coding gene Chr5:145627538-145702474 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027845
protein coding gene Chr5:128662480-128717835 (+)
CAST/EiJ MGP_CASTEiJ_G0029295
protein coding gene Chr5:138705637-138784747 (+)
CBA/J MGP_CBAJ_G0029855
protein coding gene Chr5:151286615-151364072 (+)
DBA/2J MGP_DBA2J_G0030006
protein coding gene Chr5:134257111-134327457 (+)
FVB/NJ MGP_FVBNJ_G0029961
protein coding gene Chr5:133405020-133476896 (+)
LP/J MGP_LPJ_G0030095
protein coding gene Chr5:140827707-140899531 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029993
protein coding gene Chr5:154300182-154377512 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030662
protein coding gene Chr5:138501860-138571231 (+)
PWK/PhJ MGP_PWKPhJ_G0029009
protein coding gene Chr5:133320191-133390399 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028844
protein coding gene Chr5:136046350-136116511 (+)
WSB/EiJ MGP_WSBEiJ_G0029368
protein coding gene Chr5:139226231-139303945 (+)



Homology
more
  • Human Ortholog
    SRRM3, serine/arginine repetitive matrix 3
  • Vertebrate Orthologs
    2
  • Human Ortholog
    SRRM3, serine/arginine repetitive matrix 3
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 222183
    UniProt: A6NNA2

  • Chr Location
    7q11.23; chr7:76201893-76287292 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased survival and body size, impaired coordination, ataxia, and tremors, Purkinje cell degeneration, and longer persistence of the cerebellum external granule cell layer.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039860 Ensembl Gene Model | MGI Sequence Detail 67883 C57BL/6J ±  kb
    transcript ENSMUST00000144211 Ensembl | MGI Sequence Detail 3932 Not Applicable  
    polypeptide ENSMUSP00000115695 Ensembl | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000030759 serine/arginine repetitive matrix protein 3
    • InterPro Domains
      IPR013170 mRNA splicing factor Cwf21 domain
      IPR029360 Serine/arginine repetitive matrix protein, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1931023
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:281311 Nakano Y, et al., Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep. 2019 Apr 16;27(3):860-871.e8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/22/2020
    MGI 6.16
    The Jackson Laboratory