Kctd16 MGI Mouse Gene Detail - MGI:1914659 - potassium channel tetramerisation domain containing 16

Symbol

Kctd16
Name

potassium channel tetramerisation domain containing 16
Synonyms

2900055J20Rik, 4930434H12Rik, LOC383347

Feature Type

protein coding gene

BioType Conflict
IDs

MGI:1914659
NCBI Gene: 383348
Alliance

genome feature page
Transcription Start Sites

18 TSS

Sequence Map

Chr18:40389358-40680311 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, Syntenic
Mapping Data

3 experiments

SNPs within 2kb

7072 from dbSNP Build 142
Strain Annotations

41

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914659	protein coding gene	Chr18:40389358-40680311 (+)
129S1/SvImJ	ENSMUSG00200040891	protein coding gene	Chr18:37396090-37676327 (+)
129S1/SvImJ	ENSMUSG00200045862	lncRNA gene	Chr18:37684469-37687709 (+)
A/J	ENSMUSG00195033447	protein coding gene	Chr18:37548634-37833012 (+)
A/J	ENSMUSG00195039042	lncRNA gene	Chr18:37841152-37844392 (+)
AKR/J	ENSMUSG00220016376	protein coding gene	Chr18:37517439-37797396 (+)
AKR/J	ENSMUSG00220017615	lncRNA gene	Chr18:37805536-37808775 (+)
AKR/J	ENSMUSG00220016372	protein coding gene	Chr18:37516373-37517095 (+)
BALB/cJ	ENSMUSG00180017103	protein coding gene	Chr18:37998246-38278508 (+)
BALB/cJ	ENSMUSG00180021011	lncRNA gene	Chr18:38286648-38289889 (+)
C3H/HeJ	ENSMUSG00175034863	protein coding gene	Chr18:37515508-37790072 (+)
C3H/HeJ	ENSMUSG00175034853	protein coding gene	Chr18:37514437-37515159 (+)
C3H/HeJ	ENSMUSG00175041781	lncRNA gene	Chr18:37798218-37801458 (+)
C57BL/6NJ	ENSMUSG00215010311	protein coding gene	Chr18:37262469-37536341 (+)
C57BL/6NJ	ENSMUSG00215032334	lncRNA gene	Chr18:37544499-37547740 (+)
C57BL/6NJ	ENSMUSG00215010302	protein coding gene	Chr18:37261400-37262122 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022220	protein coding gene	Chr18:37434779-37701563 (+)
CAST/EiJ	ENSTCUG00005020080	protein coding gene	Chr18:37134806-37416798 (+)
CAST/EiJ	ENSTCUG00005024635	lncRNA gene	Chr18:37424960-37428203 (+)
CBA/J	ENSMUSG00210021065	protein coding gene	Chr18:37540114-37831889 (+)
CBA/J	ENSMUSG00210021808	lncRNA gene	Chr18:37840027-37843267 (+)
DBA/2J	ENSMUSG00185017540	protein coding gene	Chr18:37474690-37754923 (+)
DBA/2J	ENSMUSG00185021009	lncRNA gene	Chr18:37763061-37766301 (+)
FVB/NJ	ENSMUSG00205034518	lncRNA gene	Chr18:37455699-37458939 (+)
FVB/NJ	ENSMUSG00205014594	protein coding gene	Chr18:37173840-37174562 (+)
FVB/NJ	ENSMUSG00205014601	protein coding gene	Chr18:37174906-37447580 (+)
JF1/MsJ	ENSUMUG00000049521	lncRNA gene	Chr18:37915827-37919070 (+)
JF1/MsJ	ENSUMUG00000022161	protein coding gene	Chr18:37618162-37907654 (+)
LP/J	ENSMUSG00230042402	protein coding gene	Chr18:39590943-39871168 (+)
LP/J	ENSMUSG00230049208	lncRNA gene	Chr18:39879306-39882546 (+)
NOD/ShiLtJ	ENSMUSG00190020355	protein coding gene	Chr18:37264124-37543033 (+)
NOD/ShiLtJ	ENSMUSG00190020342	protein coding gene	Chr18:37263057-37263779 (+)
NOD/ShiLtJ	ENSMUSG00190022330	lncRNA gene	Chr18:37551173-37554413 (+)
NZO/HlLtJ	ENSMUSG00225047227	lncRNA gene	Chr18:39782053-39785293 (+)
NZO/HlLtJ	ENSMUSG00225043567	protein coding gene	Chr18:39493683-39773915 (+)
PWK/PhJ	ENSLUMG00010010949	protein coding gene	Chr18:37775951-38056127 (+)
PWK/PhJ	ENSLUMG00010013099	lncRNA gene	Chr18:38064292-38067534 (+)
SPRET/EiJ	ENSMSPG00010018950	protein coding gene	Chr18:37835482-38117753 (+)
SPRET/EiJ	ENSMSPG00010024222	lncRNA gene	Chr18:38125875-38129116 (+)
WSB/EiJ	ENSIUOG00005007319	protein coding gene	Chr18:37251988-37526476 (+)
WSB/EiJ	ENSIUOG00005008680	lncRNA gene	Chr18:37534628-37537868 (+)

Human Ortholog

KCTD16, potassium channel tetramerization domain containing 16

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCTD16, potassium channel tetramerization domain containing 16
Links

HGNC:29244

NCBI Gene ID: 57528

UniProt: Q68DU8
Chr Location

5q31.3; chr5:144170873-144485686 (+) GRCh38

MGI Vertebrate Homology

Kctd16 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KCTD16

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF , APF , CvDC
Find Mice (IMSR)

35 strains or lines available

Homozygous knockout leads to reduced extinction or increase of fear memory in cued or contextual conditioning behavior tests, respectively.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

134
Tissues

17
cDNA Data

18
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kctd16

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All Sequences

83
RefSeq

9
UniProt

4
CCDS

CCDS50264.1

Ensembl

ENSMUSG00000051401 (Evidence), ENSMUSG00000118202 (Evidence)
NCBI Gene

383348

			Length	Strain/Species	Flank
genomic	383348	NCBI Gene Model \| MGI Sequence Detail	290954	C57BL/6J	± kb
transcript	NM_001371039	RefSeq \| MGI Sequence Detail	18419	C57BL/6
polypeptide	Q5DTY9	UniProt \| EBI \| MGI Sequence Detail	427	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031813 BTB/POZ domain-containing protein KCTD16

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR057093 KCTD8/12/16, H1 domain

IPR003131 Potassium channel tetramerisation-type BTB domain

IPR049903 Potassium channel tetramerization domain-containing protein 16, H1 domain

IPR011333 SKP1/BTB/POZ domain superfamily
GlyGen

Q5DTY9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 18

Microarray probesets 4

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MGI:1920251, MGI:1924774, MGI:2686113

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:371858 Perez-Garci E, et al., Binding of HCN channels to GABA(B) receptors in dopamine neurons of the VTA limits synaptic inhibition and prevents the development of anxiety. Neurobiol Dis. 2025 Mar;206:106831

TSS for Kctd16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150842	Chr18:40389342-40389362 (+)	-6 bp
Tssr150843	Chr18:40389923-40389935 (+)	571 bp
Tssr150844	Chr18:40390000-40390004 (+)	644 bp
Tssr150845	Chr18:40390013-40390071 (+)	684 bp
Tssr150846	Chr18:40390084-40390095 (+)	732 bp
Tssr150847	Chr18:40398860-40398867 (+)	9,506 bp
Tssr150848	Chr18:40403593-40403602 (+)	14,240 bp
Tssr150849	Chr18:40404727-40404730 (+)	15,371 bp
Tssr150850	Chr18:40439121-40439133 (+)	49,769 bp
Tssr150851	Chr18:40439288-40439301 (+)	49,937 bp
Tssr150852	Chr18:40441258-40441282 (+)	51,912 bp
Tssr150853	Chr18:40465531-40465536 (+)	76,176 bp
Tssr150854	Chr18:40466288-40466292 (+)	76,932 bp
Tssr150855	Chr18:40646039-40646056 (+)	256,690 bp
Tssr150856	Chr18:40646077-40646080 (+)	256,721 bp
Tssr150857	Chr18:40656149-40656160 (+)	266,797 bp
Tssr150858	Chr18:40663802-40663823 (+)	274,455 bp
Tssr150859	Chr18:40674450-40674461 (+)	285,098 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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