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Insig2 Gene Detail
Summary
  • Symbol
    Insig2
  • Name
    insulin induced gene 2
  • Synonyms
    2900053I11Rik, C730043J18Rik, Insig-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920249
    NCBI Gene: 72999
  • Gene Overview
    MyGene.info: INSIG2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:121304353-121332589 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.91 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    390 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920249
protein coding gene Chr1:121304353-121332589 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016409
protein coding gene Chr1:124122320-124151932 (-)
A/J MGP_AJ_G0016392
protein coding gene Chr1:119670975-119699185 (-)
AKR/J MGP_AKRJ_G0016357
protein coding gene Chr1:123178013-123206214 (-)
BALB/cJ MGP_BALBcJ_G0016352
protein coding gene Chr1:119948895-119978108 (-)
C3H/HeJ MGP_C3HHeJ_G0016178
protein coding gene Chr1:123353400-123381708 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016813
protein coding gene Chr1:128863017-128893174 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014526
protein coding gene Chr1:113305140-113334272 (-)
CAST/EiJ MGP_CASTEiJ_G0015759
protein coding gene Chr1:122176143-122203874 (-)
CBA/J MGP_CBAJ_G0016151
protein coding gene Chr1:133302163-133334570 (-)
DBA/2J MGP_DBA2J_G0016257
protein coding gene Chr1:118693583-118723741 (-)
FVB/NJ MGP_FVBNJ_G0016256
protein coding gene Chr1:117458202-117485007 (-)
LP/J MGP_LPJ_G0016328
protein coding gene Chr1:125478425-125508593 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016281
protein coding gene Chr1:139006896-139036473 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016849
protein coding gene Chr1:122935300-122964511 (-)
PWK/PhJ MGP_PWKPhJ_G0015545
protein coding gene Chr1:117701693-117730346 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015333
protein coding gene Chr1:121848898-121875735 (-)
WSB/EiJ MGP_WSBEiJ_G0015821
protein coding gene Chr1:122810831-122841809 (-)



Homology
more
  • Human Ortholog
    INSIG2, insulin induced gene 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    INSIG2, insulin induced gene 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INSIG-2
  • Links
    NCBI Gene ID: 51141
    neXtProt AC: NX_Q9Y5U4
    UniProt: Q9Y5U4

  • Chr Location
    2q14.1-q14.2; chr2:118088418-118110031 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from multigenic genotypes
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72999 NCBI Gene Model | MGI Sequence Detail 28237 C57BL/6J ±  kb
transcript NM_133748 RefSeq | MGI Sequence Detail 2711 C57BL/6  
polypeptide Q91WG1 UniProt | EBI | MGI Sequence Detail 225 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • InterPro Domains
    IPR025929 Insulin-induced protein family
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 5
Other
Accession IDs
less
MGI:2443230
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:264124 Tsushima H, et al., Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. Development. 2018 Jul 9;145(13)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory