About   Help   FAQ
Ciz1 Gene Detail
Summary
  • Symbol
    Ciz1
  • Name
    CDKN1A interacting zinc finger protein 1
  • Synonyms
    0610038H21Rik, 2900056O04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920234
    NCBI Gene: 68379
  • Gene Overview
    MyGene.info: CIZ1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32363005-32378313 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.09 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920234
protein coding gene Chr2:32352327-32380970 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025603
protein coding gene Chr2:30797810-30830982 (+)
A/J MGP_AJ_G0025580
protein coding gene Chr2:29496849-29525254 (+)
AKR/J MGP_AKRJ_G0025550
protein coding gene Chr2:30551245-30581253 (+)
BALB/cJ MGP_BALBcJ_G0025577
protein coding gene Chr2:29622222-29651046 (+)
C3H/HeJ MGP_C3HHeJ_G0025337
protein coding gene Chr2:30440953-30472640 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026021
protein coding gene Chr2:31743987-31773040 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023430
protein coding gene Chr2:28233641-28251209 (+)
CAST/EiJ MGP_CASTEiJ_G0024799
protein coding gene Chr2:30380153-30408591 (+)
CBA/J MGP_CBAJ_G0025315
protein coding gene Chr2:32938489-32969510 (+)
DBA/2J MGP_DBA2J_G0025448
protein coding gene Chr2:29263965-29294184 (+)
FVB/NJ MGP_FVBNJ_G0025410
protein coding gene Chr2:29139845-29170556 (+)
LP/J MGP_LPJ_G0025534
protein coding gene Chr2:30677490-30708836 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025441
protein coding gene Chr2:32601037-32630335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026079
protein coding gene Chr2:30430974-30462572 (+)
PWK/PhJ MGP_PWKPhJ_G0024547
protein coding gene Chr2:29168337-29197418 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024347
protein coding gene Chr2:30589812-30619373 (+)
WSB/EiJ MGP_WSBEiJ_G0024868
protein coding gene Chr2:30603228-30635399 (+)



Homology
more
  • Human Ortholog
    CIZ1, CDKN1A interacting zinc finger protein 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CIZ1, CDKN1A interacting zinc finger protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LSFR1, NP94, ZNF356
  • Links
    NCBI Gene ID: 25792
    neXtProt AC: NX_Q9ULV3
    UniProt: Q9ULV3

  • Chr Location
    9q34.11; chr9:128166065-128204383 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice hoomozygous for a knock-out allele exhibit decreased body size and gender specific effects on motor phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68379 NCBI Gene Model | MGI Sequence Detail 15309 C57BL/6J ±  kb
    transcript NM_001252534 RefSeq | MGI Sequence Detail 3010 C57BL/6  
    polypeptide NP_082688 RefSeq | MGI Sequence Detail 845 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      16 Sequences
    • InterPro Domains
      IPR026811 Cip1-interacting zinc finger protein
      IPR000690 Matrin/U1-C, C2H2-type zinc finger
      IPR003604 Matrin/U1-C-like, C2H2-type zinc finger
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
      IPR022755 Zinc finger, double-stranded RNA binding
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 13
      Primer pair 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915629
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:258054 Khan MM, et al., DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice. Neurobiol Aging. 2018 Feb;62:180-190

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory