Ciz1 MGI Mouse Gene Detail - MGI:1920234 - CDKN1A interacting zinc finger protein 1

Symbol

Ciz1
Name

CDKN1A interacting zinc finger protein 1
Synonyms

0610038H21Rik, 2900056O04Rik

Feature Type

protein coding gene
IDs

MGI:1920234
NCBI Gene: 68379
Gene Overview

MyGene.info: CIZ1
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:32363005-32378313 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 22.09 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

18 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920234	protein coding gene	Chr2:32352327-32380970 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025603	protein coding gene	Chr2:30797810-30830982 (+)
A/J	MGP_AJ_G0025580	protein coding gene	Chr2:29496849-29525254 (+)
AKR/J	MGP_AKRJ_G0025550	protein coding gene	Chr2:30551245-30581253 (+)
BALB/cJ	MGP_BALBcJ_G0025577	protein coding gene	Chr2:29622222-29651046 (+)
C3H/HeJ	MGP_C3HHeJ_G0025337	protein coding gene	Chr2:30440953-30472640 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026021	protein coding gene	Chr2:31743987-31773040 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023430	protein coding gene	Chr2:28233641-28251209 (+)
CAST/EiJ	MGP_CASTEiJ_G0024799	protein coding gene	Chr2:30380153-30408591 (+)
CBA/J	MGP_CBAJ_G0025315	protein coding gene	Chr2:32938489-32969510 (+)
DBA/2J	MGP_DBA2J_G0025448	protein coding gene	Chr2:29263965-29294184 (+)
FVB/NJ	MGP_FVBNJ_G0025410	protein coding gene	Chr2:29139845-29170556 (+)
LP/J	MGP_LPJ_G0025534	protein coding gene	Chr2:30677490-30708836 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025441	protein coding gene	Chr2:32601037-32630335 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026079	protein coding gene	Chr2:30430974-30462572 (+)
PWK/PhJ	MGP_PWKPhJ_G0024547	protein coding gene	Chr2:29168337-29197418 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024347	protein coding gene	Chr2:30589812-30619373 (+)
WSB/EiJ	MGP_WSBEiJ_G0024868	protein coding gene	Chr2:30603228-30635399 (+)

Human Ortholog

CIZ1, CDKN1A interacting zinc finger protein 1

Vertebrate Orthologs

7

Human Ortholog

CIZ1, CDKN1A interacting zinc finger protein 1
Orthology source: HomoloGene, HGNC
Synonyms

LSFR1, NP94, ZNF356
Links

HGNC:16744

NCBI Gene ID: 25792

neXtProt AC: NX_Q9ULV3

UniProt: Q9ULV3
Chr Location

9q34.11; chr9:128166065-128204383 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8112
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: CIZ1
Gene Tree

Ciz1

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice hoomozygous for a knock-out allele exhibit decreased body size and gender specific effects on motor phenotypes.

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All GO Annotations

8
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

347
Tissues

104
cDNA Data

11
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ciz1

ZFIN ciz1b

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Ciz1 interacts with 72 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

159
RefSeq

66
UniProt

16
CCDS

CCDS15911.1, CCDS57166.1

Ensembl

ENSMUSG00000039205 (Evidence)
NCBI Gene

68379

			Length	Strain/Species	Flank
genomic	68379	NCBI Gene Model \| MGI Sequence Detail	15309	C57BL/6J	± kb
transcript	NM_001252534	RefSeq \| MGI Sequence Detail	3010	C57BL/6
polypeptide	NP_082688	RefSeq \| MGI Sequence Detail	845	C57BL/6

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UniProt

16 Sequences
InterPro Domains

IPR026811 Cip1-interacting zinc finger protein

IPR000690 Matrin/U1-C, C2H2-type zinc finger

IPR003604 Matrin/U1-C-like, C2H2-type zinc finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

IPR022755 Zinc finger, double-stranded RNA binding

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All nucleic 19

cDNA 13

Primer pair 6

Microarray probesets 4

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MGI:1915629

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:273464 Stewart ER, et al., Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture. Nat Commun. 2019 Jan 28;10(1):460

TSS for Ciz1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17262	Chr2:32363004-32363142 (+)	68 bp
Tssr17263	Chr2:32363168-32363177 (+)	168 bp
Tssr17264	Chr2:32363192-32363262 (+)	222 bp
Tssr17265	Chr2:32363680-32363693 (+)	682 bp
Tssr17266	Chr2:32374386-32374422 (+)	11,399 bp
Tssr17267	Chr2:32376299-32376315 (+)	13,302 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14