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Wdr11 Gene Detail
Summary
  • Symbol
    Wdr11
  • Name
    WD repeat domain 11
  • Synonyms
    2900055P10Rik, Brwd2, MGC:47139, Wdr11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920230
    NCBI Gene: 207425
  • Gene Overview
    MyGene.info: WDR11
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:129591863-129635738 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 72.37 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    593 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920230
protein coding gene Chr7:129591713-129635738 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033089
protein coding gene Chr7:134071144-134119048 (+)
A/J MGP_AJ_G0033071
protein coding gene Chr7:130427984-130471346 (+)
AKR/J MGP_AKRJ_G0033003
protein coding gene Chr7:133885920-133929292 (+)
BALB/cJ MGP_BALBcJ_G0033072
protein coding gene Chr7:130101400-130145215 (+)
C3H/HeJ MGP_C3HHeJ_G0032786
protein coding gene Chr7:133764695-133808724 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033582
protein coding gene Chr7:139255897-139299137 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030554
protein coding gene Chr7:131605629-131651007 (+)
CAST/EiJ MGP_CASTEiJ_G0032116
protein coding gene Chr7:125565807-125616016 (+)
CBA/J MGP_CBAJ_G0032759
protein coding gene Chr7:144011769-144058073 (+)
DBA/2J MGP_DBA2J_G0032911
protein coding gene Chr7:128427007-128470293 (+)
FVB/NJ MGP_FVBNJ_G0032864
protein coding gene Chr7:128288535-128332255 (+)
LP/J MGP_LPJ_G0033005
protein coding gene Chr7:135548511-135595737 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032896
protein coding gene Chr7:145041580-145086189 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033601
protein coding gene Chr7:132825293-132869785 (+)
PWK/PhJ MGP_PWKPhJ_G0031822
protein coding gene Chr7:121462016-121509368 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031668
protein coding gene Chr7:119655929-119707045 (+)
WSB/EiJ MGP_WSBEiJ_G0032227
protein coding gene Chr7:133817073-133861305 (+)



Homology
more
  • Human Ortholog
    WDR11, WD repeat domain 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WDR11, WD repeat domain 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRWD2, DR11, HH14, SRI1, WDR15
  • Links
    NCBI Gene ID: 55717
    neXtProt AC: NX_Q9BZH6
    UniProt: Q9BZH6

  • Chr Location
    10q26.12; chr10:120851175-120909526 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41229
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: WDR11
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Wdr11 mouse models; 2 with human WDR11 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice show mid-gestational and perinatal lethality and developmental anomalies associated with defective Hh signalling and ciliogenesis, including eye, skeletal, heart and craniofacial defects, holoprosencephaly, pituitary dysgenesis, delayed puberty, reproductive dysfunction and obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042055 Ensembl Gene Model | MGI Sequence Detail 43876 C57BL/6J ±  kb
    transcript ENSMUST00000084519 Ensembl | MGI Sequence Detail 4550 Not Applicable  
    polypeptide ENSMUSP00000081567 Ensembl | MGI Sequence Detail 1223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 78
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142234
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:257035 Kim YJ, et al., WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. EMBO Rep. 2018 Feb;19(2):269-289

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory