Tymp
Gene Detail

Symbol Name ID

Tymp thymidine phosphorylase MGI:1920212

Synonyms

2900072D10Rik, Ecgf1, gliostatin, PDECGF, PD-ECGF, Pdgfec

Feature Type

protein coding gene

Genetic Map

Chromosome 15

44.86 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr15:89371931-89377036 bp, - strand From NCBI annotation of GRCm38   5106 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: thymidine phosphorylase/pyrimidine-nucleoside phosphorylase
Gene Tree: Tymp

Human homologs

Human Homolog		TYMP, thymidine phosphorylase
NCBI Gene ID		1890
neXtProt AC		NX_P19971
Human Synonyms		ECGF, ECGF1, hPD-ECGF, MEDPS1, MNGIE, MTDPS1, PDECGF, TP
Human Chr (Location)		22q13.33; chr22:50964181-50968514 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TYMP

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(2)
 

Mice homozygous for a null allele exhibit reduced thymidine phosphorylase activity and increased thymidine levels.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	chemotaxis, metabolic process, ...
Function	phosphorylase activity, pyrimidine-nucleoside phosphorylase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (135)    Tissues (121)    Images (3)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	135

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022615 (Evidence)
Entrez Gene	72962 (Evidence)
EC	2.4.2.4
Consensus CDS Project	CCDS27747.1
International Mouse Knockout Project Status	Tymp

Sequences

Length	Strain/Species
genomic	72962	NCBI Gene Model | MGI Sequence Detail	5106	C57BL/6J
transcript	NM_138302	RefSeq | MGI Sequence Detail	2042	Not Specified
polypeptide	Q99N42	UniProt | EBI | MGI Sequence Detail	471	Not Applicable

All sequences(11) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000312	Glycosyl transferase, family 3
InterPro	IPR017459	Glycosyl transferase family 3, N-terminal domain
InterPro	IPR000053	Pyrimidine-nucleoside phosphorylase
InterPro	IPR018090	Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic
InterPro	IPR013102	Pyrimidine nucleoside phosphorylase, C-terminal
Protein Ontology	PR:000016875	thymidine phosphorylase

Graphical View of Protein Domain Structure

References

(Earliest) J:1670 Brannan CI, et al., An interspecific linkage map of mouse chromosome 15 positioned with respect to the centromere. Genomics. 1992 Aug;13(4):1075-81
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)

Other accession IDs

MGD-MRK-13213, MGI:97529