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Tymp Gene Detail
Summary
  • Symbol
    Tymp
  • Name
    thymidine phosphorylase
  • Synonyms
    2900072D10Rik, Ecgf1, gliostatin, PDECGF, PD-ECGF, Pdgfec
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920212
    NCBI Gene: 72962
  • Gene Overview
    MyGene.info: TYMP
Location & Maps
more
  • Sequence Map
    Chr15:89371931-89377036 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5106 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 44.86 cM, cytoband F1
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    TYMP, thymidine phosphorylase
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TYMP, thymidine phosphorylase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ECGF, ECGF1, hPD-ECGF, MEDPS1, MNGIE, MTDPS1, PDECGF, TP
  • Links
    NCBI Gene ID: 1890
    neXtProt AC: NX_P19971

  • Chr Location
    22q13.33; chr22:50525752-50530085 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tymp mouse models; 1 with human TYMP associations

Human Disease Mouse Models
       Mitochondrial DNA Depletion Syndrome 1 (mngie Type); MTDPS1   OMIM: 603041 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Tymp
  • Incidental Mutations
Mice homozygous for a null allele exhibit reduced thymidine phosphorylase activity and increased thymidine levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 72962 NCBI Gene Model | MGI Sequence Detail 5106 C57BL/6J ±  kb
transcript NM_138302 RefSeq | MGI Sequence Detail 2042 Not Specified  
polypeptide Q99N42 UniProt | EBI | MGI Sequence Detail 471 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    19 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016875 thymidine phosphorylase
  • EC
  • InterPro Domains
    IPR000312 Glycosyl transferase, family 3
    IPR017459 Glycosyl transferase family 3, N-terminal domain
    IPR018090 Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic
    IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal
    IPR000053 Thymidine/pyrimidine-nucleoside phosphorylase
Molecular
Reagents
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  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13213, MGI:97529
References
more
  • Summaries
    All 44
    Developmental Gene Expression 2
    Diseases 4
    Gene Ontology 5
    Phenotypes 27
  • Earliest
    J:1670 Brannan CI, et al., An interspecific linkage map of mouse chromosome 15 positioned with respect to the centromere. Genomics. 1992 Aug;13(4):1075-81
  • Latest
    J:209064 Camara Y, et al., Administration of deoxyribonucleosides or inhibition of their catabolism as a pharmacological approach for mitochondrial DNA depletion syndrome. Hum Mol Genet. 2014 May 1;23(9):2459-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory