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Tymp
Gene Detail
Symbol

Name
ID
Tymp
thymidine phosphorylase
MGI:1920212
Synonyms
2900072D10Rik, Ecgf1, gliostatin, PDECGF, PD-ECGF, Pdgfec
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.86 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr15:89371931-89377036 bp, - strand
From NCBI annotation of GRCm38

  5106 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 western clawed frog

Protein SuperFamily: thymidine phosphorylase/pyrimidine-nucleoside phosphorylase
Gene Tree: Tymp

Human
homologs
Human Homolog TYMP, thymidine phosphorylase
NCBI Gene ID 1890
neXtProt AC  NX_P19971
Human Synonyms  ECGF, ECGF1, hPD-ECGF, MEDPS1, MNGIE, MTDPS1, PDECGF, TP
Human Chr (Location)  22q13.33; chr22:50525752-50530085 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TYMP
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Radiation induced(1) Targeted(5)
Genomic Mutations involving Tymp (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit reduced thymidine phosphorylase activity and increased thymidine levels.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Tymp interacts with 56 markers (Mir34a, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process chemotaxis, metabolic process, ...
Function phosphorylase activity, pyrimidine-nucleoside phosphorylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (135)    Tissues (121)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 135
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022615 (Evidence)
Entrez Gene72962 (Evidence)
EC2.4.2.4
Consensus CDS ProjectCCDS27747.1
International Mouse Knockout Project StatusTymp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 72962 NCBI Gene Model | MGI Sequence Detail 5106 C57BL/6J ±  kb
transcript NM_138302 RefSeq | MGI Sequence Detail 2042 Not Specified 
polypeptide Q99N42 UniProt | EBI | MGI Sequence Detail 471 Not Applicable 

For the selected sequences
All sequences(11) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000312 Glycosyl transferase, family 3
InterPro IPR017459 Glycosyl transferase family 3, N-terminal domain
InterPro IPR000053 Pyrimidine-nucleoside phosphorylase
InterPro IPR018090 Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic
InterPro IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal
Protein Ontology PR:000016875 thymidine phosphorylase
Graphical View of Protein Domain Structure
References
(Earliest) J:1670 Brannan CI, et al., An interspecific linkage map of mouse chromosome 15 positioned with respect to the centromere. Genomics. 1992 Aug;13(4):1075-81
(Latest) J:209064 Camara Y, et al., Administration of deoxyribonucleosides or inhibition of their catabolism as a pharmacological approach for mitochondrial DNA depletion syndrome. Hum Mol Genet. 2014 May 1;23(9):2459-67
All references(45)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13213, MGI:97529

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory