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Slc17a7 Gene Detail
Summary
  • Symbol
    Slc17a7
  • Name
    solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
  • Synonyms
    2900052E22Rik, Vglut1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920211
    NCBI Gene: 72961
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:45163949-45176142 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      12194 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.16 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC17A7, solute carrier family 17 member 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC17A7, solute carrier family 17 member 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BNPI, VGLUT1
  • Links
    NCBI Gene ID: 57030
    neXtProt AC: NX_Q9P2U7
    UniProt: Q9P2U7

  • Chr Location
    19q13.33; chr19:49429398-49441551 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 5 alleles in 6 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are small and fail to thrive by 3-4 weeks of age. Abnormal excitatory post synaptic potential and currents.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    43
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    79
  • Tissues
    34
  • cDNA Data
    30
  • Literature Summary
    83
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000058649 VEGA Gene Model | MGI Sequence Detail 12194 C57BL/6J ±  kb
    transcript OTTMUST00000144034 VEGA | MGI Sequence Detail 1860 Not Applicable  
    polypeptide OTTMUSP00000075093 VEGA | MGI Sequence Detail 585 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      63 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR011701 Major facilitator superfamily
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 31
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142059
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 83
      Gene Ontology 21
      Phenotypes 32
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:257839 Li S, et al., Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior. Cell Res. 2018 Feb;28(2):221-248
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory