Slc17a7 MGI Mouse Gene Detail - MGI:1920211 - solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7

Slc17a7 Gene Detail

Symbol

Slc17a7
Name

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
Synonyms

2900052E22Rik, Vglut1

Feature Type

protein coding gene
IDs

MGI:1920211
NCBI Gene: 72961

Sequence Map

Chr7:45163949-45176142 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

12194 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.16 cM
Mapping Data

2 experiments

Human Ortholog

SLC17A7, solute carrier family 17 member 7

Vertebrate Orthologs

9

Human Ortholog

SLC17A7, solute carrier family 17 member 7
Orthology source: HomoloGene, HGNC
Synonyms

BNPI, VGLUT1
Links

HGNC:16704

NCBI Gene ID: 57030

neXtProt AC: NX_Q9P2U7
Chr Location

19q13; chr19:49429398-49441551 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 113454
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SLC17A7
Gene Tree

Slc17a7

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Phenotype Summary

27 phenotypes from 5 alleles in 6 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Targeted

6
Incidental Mutations

Mutagenetix , APF

Homozygous mutant mice are small and fail to thrive by 3-4 weeks of age. Abnormal excitatory post synaptic potential and currents.

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All GO Annotations

42
GO References

21

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

71
Tissues

31
cDNA Data

30
Literature Summary

70

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

Xenbase slc17a7

ZFIN slc17a7a

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Slc17a7 interacts with 221 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

34
RefSeq

2
UniProt

3
CCDS

CCDS52244.1
UniGene

255631

			Length	Strain/Species	Flank
genomic	OTTMUSG00000058649	VEGA Gene Model \| MGI Sequence Detail	12194	C57BL/6J	± kb
transcript	OTTMUST00000144034	VEGA \| MGI Sequence Detail	1860	Not Applicable
polypeptide	OTTMUSP00000075093	VEGA \| MGI Sequence Detail	585	Not Applicable

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SNPs within 2kb

63 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000014963 vesicular glutamate transporter 1
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

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All nucleic 35

cDNA 31

Primer pair 3

Other 1

Microarray probesets 4

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MGI:2142059

Summaries

All 134

Developmental Gene Expression 70

Gene Ontology 21

Phenotypes 22
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:234203 Patriarchi T, et al., Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1(+/-) patients and in foxg1(+/-) mice. Eur J Hum Genet. 2016 Jun;24(6):871-80

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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