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Slc17a7 Gene Detail
Summary
  • Symbol
    Slc17a7
  • Name
    solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
  • Synonyms
    2900052E22Rik, Vglut1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920211
    NCBI Gene: 72961
Location & Maps
more
  • Sequence Map
    Chr7:45163949-45176142 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      12194 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.16 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC17A7, solute carrier family 17 member 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC17A7, solute carrier family 17 member 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BNPI, VGLUT1
  • Links
    NCBI Gene ID: 57030
    neXtProt AC: NX_Q9P2U7
    UniProt: Q9P2U7

  • Chr Location
    19q13.33; chr19:49429398-49441551 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 5 alleles in 6 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are small and fail to thrive by 3-4 weeks of age. Abnormal excitatory post synaptic potential and currents.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    44
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    71
  • Tissues
    31
  • cDNA Data
    30
  • Literature Summary
    74
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058649 VEGA Gene Model | MGI Sequence Detail 12194 C57BL/6J ±  kb
transcript OTTMUST00000144034 VEGA | MGI Sequence Detail 1860 Not Applicable  
polypeptide OTTMUSP00000075093 VEGA | MGI Sequence Detail 585 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    63 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR011701 Major facilitator superfamily
    IPR020846 Major facilitator superfamily domain
Molecular
Reagents
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  • All nucleic 35
    cDNA 31
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142059
References
more
  • Summaries
    All 140
    Developmental Gene Expression 74
    Gene Ontology 21
    Phenotypes 24
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:239523 Chen CM, et al., Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E619-E628
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/08/2017
MGI 6.10 		The Jackson Laboratory