Slc17a7
Gene Detail

Symbol

Name
ID

Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
MGI:1920211

Synonyms

2900052E22Rik, Vglut1

Feature Type

protein coding gene

Genetic Map

Chromosome 7
29.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:45163921-45176138 bp, + strand From Ensembl annotation of GRCm38   12218 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:113454  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Slc17a7

Human
homologs

Human Homolog		SLC17A7, solute carrier family 17 (vesicular glutamate transporter), member 7
NCBI Gene ID		57030
neXtProt AC		NX_Q9P2U7
Human Synonyms		BNPI, VGLUT1
Human Chr (Location)		19q13; chr19:49429398-49441551 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutant mice are small and fail to thrive by 3-4 weeks of age. Abnormal excitatory post synaptic potential and currents.

 

Interactions

Slc17a7 interacts with 221 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (39 annotations)

Process	ion transport, L-glutamate import, ...
Component	cell junction, cerebellar mossy fiber, ...
Function	extracellular-glutamate-gated chloride channel activity, inorganic phosphate transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (62 records)

Data Summary: Results (22)    Tissues (11)    Images (15)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	2
RNA in situ	16
Western blot	4

cDNA source data(29)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(33) cDNA(30) Primer pair(2) Other(1)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000070570 (Evidence)
Entrez Gene	72961 (Evidence)
UniGene	255631
DFCI	TC1622052, TC1676879, TC1698799, TC1579987
DoTS	DT.94130922, DT.94271713, DT.94150336, DT.101307992, DT.482191
NIA Mouse Gene Index	U113780
Consensus CDS Project	CCDS52244.1
International Mouse Knockout Project Status	Slc17a7

Sequences

Length	Strain/Species
genomic	ENSMUSG00000070570	Ensembl Gene Model | MGI Sequence Detail	12218	C57BL/6J
transcript	ENSMUST00000085374	Ensembl | MGI Sequence Detail	2939	Not Applicable
polypeptide	ENSMUSP00000082489	Ensembl | MGI Sequence Detail	560	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(63 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR020846	Major facilitator superfamily domain
Protein Ontology	PR:000014963	vesicular glutamate transporter 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:216181 Morel L, et al., VGluT1+ neuronal glutamatergic signaling regulates postnatal developmental maturation of cortical protoplasmic astroglia. J Neurosci. 2014 Aug 13;34(33):10950-62
All references(125)

Other
accession IDs

MGI:2142059