Slc17a7
Gene Detail

Symbol Name ID

Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 MGI:1920211

Synonyms

2900052E22Rik, Vglut1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

29.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:45163921-45176138 bp, + strand From Ensembl annotation of GRCm38   12218 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:113454  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Slc17a7

Human homologs

Human Homolog		SLC17A7, solute carrier family 17 (vesicular glutamate transporter), member 7
NCBI Gene ID		57030
neXtProt AC		NX_Q9P2U7
Human Synonyms		BNPI, VGLUT1
Human Chr (Location)		19q13; chr19:49429398-49441551 (-)  GRCh38

Alleles and phenotypes

All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutant mice are small and fail to thrive by 3-4 weeks of age. Abnormal excitatory post synaptic potential and currents.

 

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	ion transport, L-glutamate import, ...
Component	cell junction, cerebellar mossy fiber, ...
Function	inorganic phosphate transmembrane transporter activity, sodium-dependent phosphate transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (54 records)

Data Summary: Results (22)    Tissues (11)    Images (15)
Theiler Stages: 23, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	16
Western blot	4

cDNA source data(29)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(30) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000070570 (Evidence)
Entrez Gene	72961 (Evidence)
UniGene	255631
DFCI	TC1579987, TC1622052, TC1676879, TC1698799
DoTS	DT.101307992, DT.482191, DT.94130922, DT.94150336, DT.94271713
NIA Mouse Gene Index	U113780
Consensus CDS Project	CCDS52244.1
International Mouse Knockout Project Status	Slc17a7

Sequences

Length	Strain/Species
genomic	ENSMUSG00000070570	Ensembl Gene Model | MGI Sequence Detail	12218	C57BL/6J
transcript	ENSMUST00000085374	Ensembl | MGI Sequence Detail	2939	Not Applicable
polypeptide	ENSMUSP00000082489	Ensembl | MGI Sequence Detail	560	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(63 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
Protein Ontology	PR:000014963	vesicular glutamate transporter 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206458 Biesemann C, et al., Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. EMBO J. 2014 Jan 13;33(2):157-70
All references(114)

Other accession IDs

MGI:2142059