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Slc17a7 Gene Detail
Summary
  • Symbol
    Slc17a7
  • Name
    solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
  • Synonyms
    2900052E22Rik, Vglut1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920211
    NCBI Gene: 72961
Location & Maps
more
  • Sequence Map
    Chr7:45163921-45176138 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12218 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    SLC17A7, solute carrier family 17 (vesicular glutamate transporter), member 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC17A7, solute carrier family 17 (vesicular glutamate transporter), member 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BNPI, VGLUT1
  • Links
    NCBI Gene ID: 57030
    neXtProt AC: NX_Q9P2U7

  • Chr Location
    19q13; chr19:49429398-49441551 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 5 alleles in 6 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous mutant mice are small and fail to thrive by 3-4 weeks of age. Abnormal excitatory post synaptic potential and currents.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070570 Ensembl Gene Model | MGI Sequence Detail 12218 C57BL/6J ±  kb
transcript ENSMUST00000085374 Ensembl | MGI Sequence Detail 2939 Not Applicable  
polypeptide ENSMUSP00000082489 Ensembl | MGI Sequence Detail 560 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    63 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014963 vesicular glutamate transporter 1
  • InterPro Domains
    IPR011701 Major facilitator superfamily
    IPR020846 Major facilitator superfamily domain
Molecular
Reagents
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  • All nucleic 35
    cDNA 31
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2142059
References
more
  • Summaries
    All 130
    Developmental Gene Expression 66
    Gene Ontology 22
    Phenotypes 22
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:225816 Herring BE, et al., Is Aspartate an Excitatory Neurotransmitter?. J Neurosci. 2015 Jul 15;35(28):10168-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory