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Top1mt
Gene Detail
Symbol

Name
ID
Top1mt
DNA topoisomerase 1, mitochondrial
MGI:1920210
Synonyms
2900052H09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 15
34.69 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:75657035-75678800 bp, - strand
From VEGA annotation of GRCm38

  21766 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:43082  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Top1mt

Human
homologs
Human Homolog TOP1MT, topoisomerase (DNA) I, mitochondrial
NCBI Gene ID 116447
neXtProt AC  NX_Q969P6
Human Chr (Location)  8q24.3; chr8:143309324-143359979 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Top1mt (1)
 
Mice homozygous for a null allele display increased oxidative stress and lipid peroxidation, enhanced glycolysis, and mitochondrial abnormalities.
 
Interactions
Top1mt interacts with 32 markers (Mir27a, Mir27b, Mir103-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process DNA replication, DNA topological change
Component chromosome, mitochondrial nucleoid, ...
Function DNA binding, DNA topoisomerase activity, ...
External Resources: FuncBase
Expression
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000028073 (Evidence)
Ensembl Gene ModelENSMUSG00000000934 (Evidence)
Entrez Gene72960 (Evidence)
UniGene182401
DFCITC1582058
DoTSDT.40175663
NIA Mouse Gene IndexU036306
EC5.99.1.2
Consensus CDS ProjectCCDS27547.1
International Mouse Knockout Project StatusTop1mt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028073 VEGA Gene Model | MGI Sequence Detail 21766 C57BL/6J ±  kb
transcript OTTMUST00000069534 VEGA | MGI Sequence Detail 1903 Not Applicable 
polypeptide OTTMUSP00000035332 VEGA | MGI Sequence Detail 593 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(5) UniProt(3)
Polymorphisms
SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core
InterPro IPR001631 DNA topoisomerase I
InterPro IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomain
InterPro IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
InterPro IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-type
InterPro IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-type
InterPro IPR013030 DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type
InterPro IPR013034 DNA topoisomerase I, domain 1
InterPro IPR013499 DNA topoisomerase I, eukaryotic-type
InterPro IPR025834 Topoisomerase I C-terminal domain
Protein Ontology PR:000016543 DNA topoisomerase I, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:189886 Douarre C, et al., Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism. PLoS One. 2012;7(7):e41094
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory