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Top1mt Gene Detail
Summary
  • Symbol
    Top1mt
  • Name
    DNA topoisomerase 1, mitochondrial
  • Synonyms
    2900052H09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920210
    NCBI Gene: 72960
Location & Maps
more
  • Sequence Map
    Chr15:75657035-75678800 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21766 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 34.69 cM, cytoband E1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TOP1MT, topoisomerase (DNA) I, mitochondrial
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TOP1MT, topoisomerase (DNA) I, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 116447
    neXtProt AC: NX_Q969P6

  • Chr Location
    8q24.3; chr8:143309324-143359977 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    3
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    5 involving Top1mt
Mice homozygous for a null allele display increased oxidative stress and lipid peroxidation, enhanced glycolysis, and mitochondrial abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028073 VEGA Gene Model | MGI Sequence Detail 21766 C57BL/6J ±  kb
transcript OTTMUST00000069534 VEGA | MGI Sequence Detail 1903 Not Applicable  
polypeptide OTTMUSP00000035332 VEGA | MGI Sequence Detail 593 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    107 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016543 DNA topoisomerase I, mitochondrial
  • EC
  • InterPro Domains
    IPR011010 DNA breaking-rejoining enzyme, catalytic core
    IPR001631 DNA topoisomerase I
    IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomain
    IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
    IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-type
    IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-type
    IPR013030 DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type
    IPR013034 DNA topoisomerase I, domain 1
    IPR013499 DNA topoisomerase I, eukaryotic-type
    IPR025834 Topoisomerase I C-terminal domain
Molecular
Reagents
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  • All nucleic 20
    cDNA 20

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Diseases 1
    Gene Ontology 5
    Phenotypes 26
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:210713 Sobek S, et al., Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I. Nucleic Acids Res. 2013 Nov;41(21):9848-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory