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Tppp Gene Detail
Summary
  • Symbol
    Tppp
  • Name
    tubulin polymerization promoting protein
  • Synonyms
    2900041A09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920198
    NCBI Gene: 72948
  • Gene Overview
    MyGene.info: TPPP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:74009407-74035753 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26347 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.15 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TPPP, tubulin polymerization promoting protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TPPP, tubulin polymerization promoting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p24, p25, p25alpha, TPPP1, TPPP/p25
  • Links
    NCBI Gene ID: 11076
    neXtProt AC: NX_O94811
    UniProt: O94811

  • Chr Location
    5p15.33; chr5:659862-730454 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027757 VEGA Gene Model | MGI Sequence Detail 26347 C57BL/6J ±  kb
    transcript OTTMUST00000068686 VEGA | MGI Sequence Detail 5090 Not Applicable  
    polypeptide OTTMUSP00000034779 VEGA | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      260 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145302
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:249040 Montalvo-Ortiz JL, et al., The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect. Behav Brain Res. 2016 Dec 15;315(None):71-4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory