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Hspb11 Gene Detail
Summary
  • Symbol
    Hspb11
  • Name
    heat shock protein family B (small), member 11
  • Synonyms
    2900042B11Rik, IFT25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920188
    NCBI Gene: 72938
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:107253593-107279938 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 50.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920188
protein coding gene Chr4:107253593-107284497 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028536
protein coding gene Chr4:107933851-107964540 (+)
A/J MGP_AJ_G0028499
protein coding gene Chr4:104063379-104090606 (+)
AKR/J MGP_AKRJ_G0028446
protein coding gene Chr4:106609823-106643848 (+)
BALB/cJ MGP_BALBcJ_G0028518
protein coding gene Chr4:104257405-104284390 (+)
C3H/HeJ MGP_C3HHeJ_G0028232
protein coding gene Chr4:107360968-107389267 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028958
protein coding gene Chr4:111814087-111841436 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026249
protein coding gene Chr4:99345466-99371956 (+)
CAST/EiJ MGP_CASTEiJ_G0027668
protein coding gene Chr4:105176225-105202723 (+)
CBA/J MGP_CBAJ_G0028201
protein coding gene Chr4:115437824-115467358 (+)
DBA/2J MGP_DBA2J_G0028349
protein coding gene Chr4:103687908-103714229 (+)
FVB/NJ MGP_FVBNJ_G0028317
protein coding gene Chr4:102555314-102581525 (+)
LP/J MGP_LPJ_G0028450
protein coding gene Chr4:108126931-108153227 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028343
protein coding gene Chr4:120726301-120755352 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028994
protein coding gene Chr4:106852423-106879571 (+)
PWK/PhJ MGP_PWKPhJ_G0027394
protein coding gene Chr4:101928975-101956874 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027218
protein coding gene Chr4:104247074-104273896 (+)
WSB/EiJ MGP_WSBEiJ_G0027749
protein coding gene Chr4:107032129-107060970 (+)



Homology
more
  • Human Ortholog
    HSPB11, heat shock protein family B (small) member 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSPB11, heat shock protein family B (small) member 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf41, HSPCO34, IFT25, PP25
  • Links
    NCBI Gene ID: 51668
    neXtProt AC: NX_Q9Y547
    UniProt: Q9Y547

  • Chr Location
    1p32.3; chr1:53921561-53946308 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22947
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HSPB11
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    2
  • Gene trapped
    9
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Hspb11
  • Incidental Mutations
  • Find Mice (IMSR)
Homozygous null mice show fetal growth retardation and complete neonatal death due to severe structural heart defects. Omphalocele, polydactyly, left pulmonary isomerism, and skeletal defects such as micrognathia, cleft palate, malaligned sternal vertebrae, and a small rib cage are often observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063172 Ensembl Gene Model | MGI Sequence Detail 26346 C57BL/6J ±  kb
transcript ENSMUST00000152717 Ensembl | MGI Sequence Detail 581 Not Applicable  
polypeptide ENSMUSP00000118617 Ensembl | MGI Sequence Detail 143 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 4
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:260436 Desai PB, et al., Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Mech Dev. 2018 Jun;151:10-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory