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Ddx41 Gene Detail
Summary
  • Symbol
    Ddx41
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
  • Synonyms
    2900024F02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920185
    NCBI Gene: 72935
  • Gene Overview
    MyGene.info: DDX41
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55530410-55536658 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920185
protein coding gene Chr13:55530410-55536658 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020602
protein coding gene Chr13:55019824-55026014 (-)
A/J MGP_AJ_G0020556
protein coding gene Chr13:52985238-52991419 (-)
AKR/J MGP_AKRJ_G0020534
protein coding gene Chr13:54551253-54558678 (-)
BALB/cJ MGP_BALBcJ_G0020552
protein coding gene Chr13:53217497-53223679 (-)
C3H/HeJ MGP_C3HHeJ_G0020351
protein coding gene Chr13:54362163-54368323 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020986
protein coding gene Chr13:56676979-56684832 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018568
protein coding gene Chr13:50923780-50929771 (-)
CAST/EiJ MGP_CASTEiJ_G0019865
protein coding gene Chr13:54465025-54471873 (-)
CBA/J MGP_CBAJ_G0020311
protein coding gene Chr13:58855255-58861355 (-)
DBA/2J MGP_DBA2J_G0020434
protein coding gene Chr13:52536412-52542607 (-)
FVB/NJ MGP_FVBNJ_G0020413
protein coding gene Chr13:52007216-52014128 (-)
LP/J MGP_LPJ_G0020510
protein coding gene Chr13:55272828-55278843 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020442
protein coding gene Chr13:58319304-58325501 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021029
protein coding gene Chr13:54130893-54137108 (-)
PWK/PhJ MGP_PWKPhJ_G0019621
protein coding gene Chr13:52563544-52570316 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019448
protein coding gene Chr13:53060509-53066659 (-)
WSB/EiJ MGP_WSBEiJ_G0019927
protein coding gene Chr13:54489792-54497537 (-)



Homology
more
  • Human Ortholog
    DDX41, DEAD-box helicase 41
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDX41, DEAD-box helicase 41
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABS, MPLPF
  • Links
    NCBI Gene ID: 51428
    neXtProt AC: NX_Q9UJV9
    UniProt: Q9UJV9

  • Chr Location
    5q35.3; chr5:177511577-177517326 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human DDX41 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 72935 NCBI Gene Model | MGI Sequence Detail 6249 C57BL/6J ±  kb
transcript NM_134059 RefSeq | MGI Sequence Detail 2213 Not Specified  
polypeptide Q91VN6 UniProt | EBI | MGI Sequence Detail 622 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • EC
  • InterPro Domains
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
less
  • All nucleic 113
    cDNA 113

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145174, MGI:2145211
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory