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Ddx41 Gene Detail
Summary
  • Symbol
    Ddx41
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
  • Synonyms
    2900024F02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920185
    NCBI Gene: 72935
  • Gene Overview
    MyGene.info: DDX41
Location & Maps
more
  • Sequence Map
    Chr13:55530410-55536658 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6249 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.06 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DDX41, DEAD-box helicase 41
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDX41, DEAD-box helicase 41
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ABS, MPLPF
  • Links
    NCBI Gene ID: 51428
    neXtProt AC: NX_Q9UJV9

  • Chr Location
    5q35.3; chr5:177511577-177516966 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DDX41 associations

Human Disease Mouse Models
       Myeloproliferative/Lymphoproliferative Neoplasms, Familial (multiple Types), Susceptibility To; MPLPF   OMIM: 616871
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Ddx41
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 72935 NCBI Gene Model | MGI Sequence Detail 6249 C57BL/6J ±  kb
transcript NM_134059 RefSeq | MGI Sequence Detail 2213 Not Specified  
polypeptide Q91VN6 UniProt | EBI | MGI Sequence Detail 622 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    38 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000029388 ATP-dependent RNA helicase DDX41
  • EC
  • InterPro Domains
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
less
  • All nucleic 112
    cDNA 112

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145174, MGI:2145211
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory